Field Efficacy Of Insecticide Treated Uniforms And Skin Repellents for Malaria Prevention (URCT)
Malaria
About this trial
This is an interventional prevention trial for Malaria focused on measuring malaria, personal protection, permethrin treated clothing, insect repellents, army personnel, cluster randomised trial
Eligibility Criteria
Inclusion Criteria:
Member of a platoon passes physical examination - no underlying health risks females that are not pregnant malaria negative at enrolment consents to participate
Exclusion Criteria:
Not assigned to a platoon underlying health risks - does not pass physical examination pregnant female (pregnant females are not recruited into the army) malaria positive at enrolment does not consent to participate
Sites / Locations
- Ifakara Health Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Placebo
Combo
Permethrin
DEET
placebo group receiving untreated army combat uniform and placebo lotion. Assigned interventions: Placebo lotion - a liposome lotion with no DEET Army combat uniform - army combat uniform with no permethrin
Combined intervention group of receiving Permethrin treated uniform 0.52% w/w and 30% DEET liposome formula. Ultra 30 Insect Repellent Lotion (30% Lipo DEET) One application of Lipo DEET protects for up to 12 hours. DEET is a broad spectrum insect repellent that has been extensively tested for safety and toxicity for human use and its efficacy against a broad variety of arthropod vectors. Permethrin Factory-Treated Army Combat Uniforms treated by the military apparel contractor Warmkraft Permethrin is considered the most effective clothing treatment available to prevent insect bites through fabric. The Army objective is to provide 90% bite protection for at least 50 launderings.
permethrin intervention group receiving Permethrin treated uniform 0.52% w/w and placebo lotion. Permethrin Factory-Treated Army Combat Uniforms treated by the military apparel contractor Warmkraft Placebo lotion: liposome lotion with no DEET
DEET intervention group receiving untreated army combat uniform and 30% DEET liposome formula. Ultra 30 Insect Repellent Lotion (30% Lipo DEET) Army combat uniform with no permethrin