Filgrastim and Chemotherapy Followed by Peripheral Stem Cell Transplant in Treating Patients With Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring stage I adult Hodgkin lymphoma, stage II adult Hodgkin lymphoma, stage III adult Hodgkin lymphoma, stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma, stage I grade 1 follicular lymphoma, stage I grade 2 follicular lymphoma, stage I grade 3 follicular lymphoma, stage I adult diffuse small cleaved cell lymphoma, stage I adult diffuse mixed cell lymphoma, stage I adult diffuse large cell lymphoma, stage I adult immunoblastic large cell lymphoma, stage I adult lymphoblastic lymphoma, stage I adult Burkitt lymphoma, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage III adult diffuse small cleaved cell lymphoma, stage III adult diffuse mixed cell lymphoma, stage III adult diffuse large cell lymphoma, stage III adult immunoblastic large cell lymphoma, stage III adult lymphoblastic lymphoma, stage III adult Burkitt lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, stage IV adult diffuse small cleaved cell lymphoma, stage IV adult diffuse mixed cell lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, stage IV adult lymphoblastic lymphoma, stage IV adult Burkitt lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult Burkitt lymphoma, stage I adult T-cell leukemia/lymphoma, stage II adult T-cell leukemia/lymphoma, stage III adult T-cell leukemia/lymphoma, stage IV adult T-cell leukemia/lymphoma, recurrent adult T-cell leukemia/lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, contiguous stage II adult diffuse small cleaved cell lymphoma, contiguous stage II adult diffuse mixed cell lymphoma, contiguous stage II adult immunoblastic large cell lymphoma, contiguous stage II adult diffuse large cell lymphoma, contiguous stage II adult Burkitt lymphoma, contiguous stage II adult lymphoblastic lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, noncontiguous stage II adult diffuse small cleaved cell lymphoma, noncontiguous stage II adult diffuse mixed cell lymphoma, noncontiguous stage II adult immunoblastic large cell lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult Burkitt lymphoma, noncontiguous stage II adult lymphoblastic lymphoma, contiguous stage II small lymphocytic lymphoma, noncontiguous stage II small lymphocytic lymphoma, recurrent small lymphocytic lymphoma, stage I small lymphocytic lymphoma, stage III small lymphocytic lymphoma, stage IV small lymphocytic lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: One of the following histologically confirmed diagnoses High grade non-Hodgkin's lymphoma: Immunoblastic or small noncleaved cell lymphoma (Burkitt's or non-Burkitt's) in complete or partial remission after initial therapy Localized (stage I or Zeigler stage A) small noncleaved (Burkitt's or non-Burkitt's) after relapse or incomplete response to initial therapy Lymphoblastic lymphoma in second or greater complete or partial response High risk lymphoblastic lymphoma in first complete remission or after initial therapy (high risk factors include stage IV disease, LDH greater than 2 times normal, and 2 or more extranodal sites) Intermediate grade non-Hodgkin's lymphoma: Diffuse large cell lymphoma Diffuse mixed cell lymphoma Diffuse small cleaved cell lymphoma Follicular large cell lymphoma In second or greater complete or partial remission OR High risk in first complete remission or after initial therapy High risk features include: No complete response after 12 weeks of initial combination chemotherapy Bulky disease (greater than 10 cm nodal masses or mediastinal disease involving greater than 1/3 of the chest diameter Malignant pleural effusion Liver involvement LDH greater than 2 times upper limit of normal at diagnosis At least 2 extranodal sites Low grade non-Hodgkin's lymphoma: Follicular small cleaved cell lymphoma Follicular mixed cell lymphoma Diffuse small lymphocytic lymphoma In first or greater complete response OR Following initial treatment if complete response is not achieved In second or greater complete or partial response if treated at diagnosis without clinical symptoms necessitating treatment T-cell lymphoma (nonlymphoblastic, intermediate, or high grade lymphomas) after initial therapy whether or not complete response is achieved Hodgkin's lymphoma Stage I and II disease treated with primary radiotherapy and failure of at least one combination chemotherapy regimen Stage III and IV disease with failure on mechlorethamine, vincristine, procarbazine, and prednisone (MOPP)-like regimen, alternative noncross resistant regimen (e.g., doxorubicin, bleomycin, vinblastine, and dacarbazine [ABVD]), or a combination (e.g., MOPP-ABV) High risk features allowed including: Failure to achieve initial complete remission with MOPP and/or ABVD and crossover or hybrid therapy Relapse within 6 months after initial therapy Relapse after initial radiotherapy with complete response longer than 1 year since initial therapy and subsequent failure on MOPP and/or ABVD or hybrid Bulky mediastinal disease after initial therapy and residual mass of at least 5 cm with other features of persisting disease (e.g., Gallium scan positive, high LDH, enlarging on serial x-rays, or positive biopsy) No HIV or HTLV-1 associated lymphomas No resistant or refractory lymphoma (no partial response following up to 3 courses of combination chemotherapy) No active ischemic or degenerative CNS disease NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 70 and under Performance status: Age 65-70 years: Karnofsky 80-100% Under 65 years: ECOG 0-1 (2 allowed if symptoms are directly related to lymphoma) Life expectancy: Greater than 8 weeks Hematopoietic: Not specified Hepatic: No prior or current chronic liver disease Bilirubin no greater than 1.5 mg/dL AST and alkaline phosphatase less than 2 times normal Renal: Age 65-70 years: Creatinine clearance greater than 60 mL/min (if creatinine at least 1.5 mg/dL) Under 65 years: Creatinine no greater than 1.5 mg/dL OR Creatinine clearance greater than 50 mL/min Cardiovascular: LVEF at least 45% by MUGA No symptoms of cardiac disease No active ischemic heart disease No uncontrolled hypertension Pulmonary: Age 65-70 years: If history of smoking or respiratory symptoms, spirometry and DLCO must be greater than 50% of predicted All ages: No obstructive airway disease No resting hypoxemia (PO_2 less than 80) DLCO at least 50% of predicted Other: No poorly controlled diabetes PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics Must have prior chemotherapy to attempt to achieve complete response Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics No radiotherapy to residual disease prior to transplantation Surgery: Not specified Other: Concurrent IV antibiotic therapy allowed for fever or signs of infection
Sites / Locations
- University of Minnesota Cancer Center