Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects
Periodontal Diseases, Periodontal Disease, AVDC Stage 3, Periodontal Disease, AVDC Stage 4
About this trial
This is an interventional treatment trial for Periodontal Diseases focused on measuring Periodontal disease, Enamel Matrix Derivative, EMD, Flapless, MINST, Periodontal treatment, Furcation defect
Eligibility Criteria
Inclusion Criteria:
- Individuals of at least 18 years of age with a diagnosis of stage III or IV periodontitis.
- Have at least one class II furcation defect with PPD >4 mm and horizontal probing depth of >= 3 mm in a mandibular first or second molar.
- Teeth have to be vital or properly treated endodontically.
- Gingival recession ≤ 2mm on furcation site
- Proper oral hygiene: full-mouth plaque score (FMPS) ≤20%.
- Systemically healthy (absence of systemic conditions such as diabetes mellitus that can affect the treatment outcome of periodontal therapy)
- Ability to understand the study procedures and comply with them through the length of the study.
- Given written informed consent form for participation in the study.
Exclusion Criteria:
- Pregnant or lactating female (self-reported).
- Current acute infection.
- Non-surgical periodontal treatment within the last 6 months or/and surgical periodontal treatment the last 12 months before the initial pre-treatment.
- Need for antibiotic premedication.
- Antibiotic treatment in the previous 3 months.
- Allergy to any materials or medications that could be used during or after the procedure.
- Teeth having an improper endodontic therapy with clinical signs of infection or subgingival restorations.
- Tooth mobility of 2nd and 3rd degree.
- History of radiation therapy in the head and neck region.
- Chronic use of medications that may alter the response of periodontal tissues.
- Smoke ≥ 10 cigarettes/day.
Sites / Locations
- Aristotle University of Thessaloniki, School of DentistryRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Subgingival debridement + Flapless Enamel Matrix Derivative
Periodontal surgery + Enamel Matrix Derivative
Subgingival debridement following a minimally-invasive non-surgical treatment (MINST) approach with flapless application of EMD Root instrumentation under local anesthesia using mini hand instruments (mini curettes) and ultrasonic instruments with fine tips in the furcation area of mandibular first or second molars with class II buccal furcation defects. EDTA gel will be applied for 2 minutes on the affected root surfaces, followed by rinsing with saline and drying prior to the application of Emdogain® FL. Emdogain® FL has been shown to enhance the early healing of periodontal soft tissue wounds resulting from the instrumentation of periodontal pockets.
Periodontal surgery following a minimally-invasive surgical treatment (MIST) protocol with application of EMD Following local anesthesia, minimal flap elevation on the buccal aspect of first or second molars associated with a grade II furcation defect will be performed.Removal of granulation tissues and root instrumentation with mini hand instruments (mini curettes) and ultrasonic instruments with fine tips in the furcation area will then be carried out. EDTA gel will be applied for 2 minutes on the affected root surfaces, followed by rinsing with saline and drying prior to the application of Emdogain®. Then, the surgical flaps will be positioned and sutured in order to completely cover the defects.