Fluorouracil With or Without Cisplatin in Treating Patients With Advanced or Metastatic Cancer of the Pancreas
Pancreatic Cancer
About this trial
This is an interventional treatment trial for Pancreatic Cancer focused on measuring stage III pancreatic cancer, adenocarcinoma of the pancreas, stage IV pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologic or cytologic proof of adenocarcinoma of the exocrine pancreas or of a metastasis associated with a radiologically identified pancreatic tumor Locally advanced and/or metastatic pancreatic cancer No measurable or evaluable target lesion is required No brain metastasis PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 40%-100% Hematopoietic: WBC at least 3,000/mm^3 Neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin no greater than 3 times normal Renal: Creatinine no greater than 1.24 mg/dL OR Creatinine clearance at least 80 mL/min Cardiovascular: No overt cardiac disease Other: No peripheral neuropathy No uncontrolled infectious or chronic disease No second primary except in situ carcinoma of the cervix, or basal or squamous cell carcinoma of the skin PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent immunologic therapy Chemotherapy: No prior chemotherapy allowed Endocrine therapy: No concurrent hormonal therapy At least 2 weeks since corticoid treatment Radiotherapy: No prior radiotherapy allowed except as an analgesic treatment on metastasis Surgery: Not specified
Sites / Locations
- Hopital de Jolimont
- Les Cliniques Saint-Joseph ASBL
- Centre Hospitalier de la Cote Basque
- Centre Jean Perrin
- Centre de Lutte Contre le Cancer, Georges-Francois Leclerc
- Hopital Perpetuel Secours
- Centre Hospital Regional Universitaire de Limoges
- Hopital Notre-Dame de Bon Secours
- Centre Hospitalier de Montlucon
- Clinique Hartmann
- Hopital Saint-Louis
- Hopital Cochin
- Centre Rene Huguenin
- Hopital Bellevue
- Clinique de l'Orangerie
- Hopital Paul Brousse
- Wolfson Medical Center
- Universita G.D'Annunzio Di Chieti
- Hospital Fernando Fonseca