FMRI-neurofeedback in Depression
Depression, Unipolar
About this trial
This is an interventional treatment trial for Depression, Unipolar focused on measuring Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders, Mental Disorders, fMRI Neurofeedback
Eligibility Criteria
Inclusion Criteria: Diagnosis of a depressive disorder (ICD-10: F32 or F33) Has been on stable antidepressant medication (single or combination treatment) for at least 4 weeks Current depression (QIDS >= 17) If required to meet recruitment targets the minimum entry score will be reduced QIDS >= 13 (i.e. still corresponding to a moderate level of depression) Exclusion Criteria: Exclusion criteria for MRI (e.g. cardiac pacemaker, certain metallic implants) History of psychotic disorder bipolar disorder, or psychotic depression Current use of illegal drugs (any in the last four weeks) Current excessive alcohol consumption that interferes with daily functioning History of neurological disease that could influence the fMRI signal and/or the anatomical alignment (e.g. territorial stroke, multiple sclerosis, brain tumour)
Sites / Locations
- Mondriaan ZorggroepRecruiting
- Maastricht UniversityRecruiting
- Maastricht UMC+Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Emotion network up-regulation + standard care
Standard care
NF protocol targeting emotion networks (NFE) (plus standard care)
Continuation of treatment as usual.