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Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly (Fruisenior) (Fruisenior)

Primary Purpose

Healthy

Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
fruit paste matrice
Sponsored by
University Hospital, Clermont-Ferrand
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional health services research trial for Healthy focused on measuring Fruit pastes matrices, Elderly healthy volunteer, Dietary intake

Eligibility Criteria

65 Years - undefined (Older Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Male subject
  • Subject over 65 years (included)
  • Subject over 61 kg (included)
  • Able to consume the 80g of fruit pastes in 10 minutes
  • Subject with a dentition consistent with the fruit paste consumption in 10 minutes
  • Subject with a Body Mass Index (BMI) between 21 and 30 kg/m2
  • Subject agreeing to provide written consent

Exclusion Criteria:

  • Subject with acute pathology (unstable or terminal pathology, severe dementia)
  • Subject with renal failure (clearance < 60 ml/min)
  • Subject with metabolic syndrome (3 of the following 5 criteria: waist greater than 94 cm, blood triglyceride greater than 1.7 mmol/l, blood pressure greater than or equal to 130 mm Hg/85 mm Hg, cholesterol (HDL) less than 1.0 mmol/l in men, blood glucose greater than or equal to 5.6 mmol/l)
  • Person with diabetes
  • Subject on food restriction
  • Subject undergoing chemotherapy
  • Subject with gastrointestinal pathology
  • Subject in a diet incompatible with the nutritional protocol (gluten, lactose or milk intolerance, vegan)

Sites / Locations

  • CHU de Clermont-Ferrand

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm Type

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

Original recipe

maltodextrin recipe

fructose recipe

isomaltulose recipe

mixed recipe

Arm Description

Normal fruit paste

fruit pastes in which some of the simple sugars in the recipe will be replaced by maltodextrin with a low glycemic index (DE12).

fruit pastes in which some of the simple sugars in the recipe (25% min) will be replaced by fructose

fruit pastes with some of the sugars will be replaced (25% min) by isomaltulose

fruit pastes with some of the sugars will be replaced (25% min) by fructose / isomaltulose

Outcomes

Primary Outcome Measures

Area Under the Curve (AUC) of glycemia
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glycemia
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glycemia
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glycemia
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glycemia
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glycemia
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glycemia
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glycemia
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glycemia
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glycemia
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glycemia
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glycemia
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glycemia
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glycemia
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of glycemia
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.

Secondary Outcome Measures

Area Under the Curve (AUC) of fructose
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of fructose
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of fructose
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of fructose
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of fructose
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of fructose
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of fructose
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of fructose
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of fructose
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of fructose
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of fructose
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of fructose
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of fructose
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of fructose
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of fructose
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glucagon
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glucagon
: Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glucagon
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glucagon
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of glucagon
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of glucagon
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of glucagon
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of glucagon
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glucagon
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of glucagon
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of glucagon
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glucagon
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of glucagon
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of glucagon
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of glucagon
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of CCK
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of CCK
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of CCK
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of CCK
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of CCK
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of CCK
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of CCK
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of CCK
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of CCK
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of CCK
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of CCK
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of CCK
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of CCK
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of CCK
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of CCK
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of Grehlin
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of Grehlin
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of Grehlin
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of Grehlin
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of Grehlin
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of Grehlin
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of Grehlin
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of Grehlin
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of Grehlin
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of Grehlin
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of leptin
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of leptin
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of leptin
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of leptin
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of leptin
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of leptin
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of leptin
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of leptin
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of leptin
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of leptin
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of leptin
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of leptin
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of leptin
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of leptin
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of leptin
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of GLP1
Area Under the Curve (AUC) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of GLP1
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of GLP1
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of GLP1
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of GLP1
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of GLP1
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of GLP1
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of GLP1
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of GLP1
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of GLP1
Area Under the Curve (AUC) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of GLP1
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of GLP1
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of GLP1
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of GLP1
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of GLP1
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of incretines
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of incretines
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of incretines
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of incretines
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of incretines
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of incretines
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of incretines
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of incretines
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of incretines
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of incretines
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of incretines
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of incretines
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of incretines
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of incretines
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of incretines
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of insulin
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of insulin
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of insulin
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of insulin
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of insulin
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of insulin
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of insulin
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of insulin
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of insulin
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Area Under the Curve (AUC) of insulin
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of insulin
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of insulin
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of insulin
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of insulin
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of urea
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of urea
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of urea
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of urea
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of urea
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of urea
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of urea
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time of Maximum Plasma Concentration (Tmax) of urea
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Area Under the Curve (AUC) of urea
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Maximum Plasma Concentration (Cmax) of urea
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time of Maximum Plasma Concentration (Tmax) of urea
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of satiety
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Questionnaire of acceptability
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Questionnaire of acceptability
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Questionnaire of acceptability
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Questionnaire of acceptability
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Questionnaire of acceptability
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Facilited individual interview
Facilitated interview to assess organoleptic, satiety and gastrointestinal comfort
Focus group
Focus group interview to assess organoleptic, satiety and gastrointestinal comfort

Full Information

First Posted
June 16, 2020
Last Updated
September 26, 2022
Sponsor
University Hospital, Clermont-Ferrand
Collaborators
Unité de Nutrition Humaine, INRAE, Centre Auvergne-Rhône Alpes, Unité de recherche CSGA, INRAE Dijon
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1. Study Identification

Unique Protocol Identification Number
NCT04482530
Brief Title
Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly (Fruisenior)
Acronym
Fruisenior
Official Title
Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly: Proof of Clinical Concept
Study Type
Interventional

2. Study Status

Record Verification Date
September 2022
Overall Recruitment Status
Completed
Study Start Date
May 31, 2021 (Actual)
Primary Completion Date
July 15, 2021 (Actual)
Study Completion Date
July 19, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Clermont-Ferrand
Collaborators
Unité de Nutrition Humaine, INRAE, Centre Auvergne-Rhône Alpes, Unité de recherche CSGA, INRAE Dijon

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
To develop more natural fruit pastes matrices that can effectively act as carbohydrate vectors in the elderly population and that are part of a normal diet while maintaining the pleasure of eating.
Detailed Description
This is an interventional randomized, single blinded, cross over and controlled study. The main objective is the study of the kinetic modification of blood glucose with the "fruit" matrices enriched in maltodextrins, fructose and isomaltulose compared to the original recipe consisting only of simple sugars. The secondary objective is: -the assessment of the acceptability of all the fruit pastes tested (organoleptic, satiety and gastrointestinal comfort aspects).The study is composed of 7 visits Visit 1 - Selection Visit (Day -7) Informed consent form Clinical examination Medical history Anthropometric characteristics Blood biochemical and hematological assessment Compliance test with the original matrix will be carried out Visit 2 (D0) / Visit 3 (D7) / Visit 4 (D14) / Visit 5 (D21) / Visit 6 (D28): study period If all the biological criteria are respected, the subjects will have to come back to the clinical center for each of the 5 study periods. Volunteers will arrive fasted, without smoking in the morning. A catheter will be placed for blood sampling. After a first blood sampling for basal values, volunteers will ingest the equivalent of two bars of fruit pastes (about 80g in 10 minutes maximum) and blood will be withdrawn 15, 30, 45, 60, 90, 120 and 180 minutes after ingestion. The different matrices (5 in total) will be tested on the same volunteer. Plasma samples will be used to determine plasma glucose and fructose concentrations (aliquots stored in center for later assays) to evaluate the postprandial profiles of these two nutrients. At the end of the kinetic, the volunteers will be offered a complete meal. A satiety questionnaire will be performed before then 60 and 180 min after the ingestion of each fruit matrix. A questionnaire of satisfaction and acceptability will also be realized during the consumption of the matrix. After the 5 fruit matrix will be tested, the subject will be invited to participate in an individual interview of about 30-45min with a member of the project team. The purpose of this interview will be a qualitative approach to search for a food development that can could improve the sensory quality of the fruit pastes tested and intended for the elderly (see below). Visit 7 (D35 to D40): Participation in a discussion group (about 2 hours). During the participation in this group all 10 participants will be invited to taste the 5 products (original recipe, maltodextrin recipe, fructose recipe, isomaltulose recipe and mixed recipe comprising fructose and isomaltulose). Participants will be asked to indicate for each product their degree of appreciation for these products, their possible defects and qualities and to suggest ideas for improving their taste / texture / appearance. These interviews will alternate individual reflection phases and discussion phases according to the focus group method. Visit 7 will be the last visit of the study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Healthy
Keywords
Fruit pastes matrices, Elderly healthy volunteer, Dietary intake

7. Study Design

Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
Participant
Masking Description
Same flavor will be used for all matrices. The different matrices will be offered to volunteers in in individual packaged portions.
Allocation
Randomized
Enrollment
15 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Original recipe
Arm Type
Experimental
Arm Description
Normal fruit paste
Arm Title
maltodextrin recipe
Arm Type
Experimental
Arm Description
fruit pastes in which some of the simple sugars in the recipe will be replaced by maltodextrin with a low glycemic index (DE12).
Arm Title
fructose recipe
Arm Type
Experimental
Arm Description
fruit pastes in which some of the simple sugars in the recipe (25% min) will be replaced by fructose
Arm Title
isomaltulose recipe
Arm Type
Experimental
Arm Description
fruit pastes with some of the sugars will be replaced (25% min) by isomaltulose
Arm Title
mixed recipe
Arm Type
Experimental
Arm Description
fruit pastes with some of the sugars will be replaced (25% min) by fructose / isomaltulose
Intervention Type
Other
Intervention Name(s)
fruit paste matrice
Intervention Description
Evaluation of the kinetics of the appearance of nutrients and the metabolic response induced by the consumption of fruit pastes (5 different matrices will be tested: 1 Original recipe, 1 maltodextrine recipe, 1 fructose recipe, 1 isomaltulose recipe and 1 mixed recipe comprising fructose and isomaltulose) in elderly healthy volunteers.
Primary Outcome Measure Information:
Title
Area Under the Curve (AUC) of glycemia
Description
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Maximum Plasma Concentration (Cmax) of glycemia
Description
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Time of Maximum Plasma Concentration (Tmax) of glycemia
Description
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Area Under the Curve (AUC) of glycemia
Description
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Maximum Plasma Concentration (Cmax) of glycemia
Description
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Time of Maximum Plasma Concentration (Tmax) of glycemia
Description
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Area Under the Curve (AUC) of glycemia
Description
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of glycemia
Description
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of glycemia
Description
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Area Under the Curve (AUC) of glycemia
Description
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of glycemia
Description
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of glycemia
Description
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of glycemia
Description
Area Under the Curve (AUC) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of glycemia
Description
Maximum Plasma Concentration (Cmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of glycemia
Description
Time of Maximum Plasma Concentration (Tmax) of glycemia (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Secondary Outcome Measure Information:
Title
Area Under the Curve (AUC) of fructose
Description
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Maximum Plasma Concentration (Cmax) of fructose
Description
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Time of Maximum Plasma Concentration (Tmax) of fructose
Description
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Area Under the Curve (AUC) of fructose
Description
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 7
Title
Maximum Plasma Concentration (Cmax) of fructose
Description
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Time of Maximum Plasma Concentration (Tmax) of fructose
Description
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Area Under the Curve (AUC) of fructose
Description
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Maximum Plasma Concentration (Cmax) of fructose
Description
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Time of Maximum Plasma Concentration (Tmax) of fructose
Description
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Area Under the Curve (AUC) of fructose
Description
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 21
Title
Maximum Plasma Concentration (Cmax) of fructose
Description
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Time of Maximum Plasma Concentration (Tmax) of fructose
Description
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Area Under the Curve (AUC) of fructose
Description
Area Under the Curve (AUC) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 28
Title
Maximum Plasma Concentration (Cmax) of fructose
Description
Maximum Plasma Concentration (Cmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Time of Maximum Plasma Concentration (Tmax) of fructose
Description
Time of Maximum Plasma Concentration (Tmax) of fructose (defined in g/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Area Under the Curve (AUC) of glucagon
Description
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of glucagon
Description
: Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of glucagon
Description
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of glucagon
Description
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of glucagon
Description
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of glucagon
Description
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 7
Title
Area Under the Curve (AUC) of glucagon
Description
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 14
Title
Maximum Plasma Concentration (Cmax) of glucagon
Description
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Time of Maximum Plasma Concentration (Tmax) of glucagon
Description
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 14
Title
Area Under the Curve (AUC) of glucagon
Description
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Maximum Plasma Concentration (Cmax) of glucagon
Description
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Time of Maximum Plasma Concentration (Tmax) of glucagon
Description
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Area Under the Curve (AUC) of glucagon
Description
Area Under the Curve (AUC) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 28
Title
Maximum Plasma Concentration (Cmax) of glucagon
Description
Maximum Plasma Concentration (Cmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Time of Maximum Plasma Concentration (Tmax) of glucagon
Description
Time of Maximum Plasma Concentration (Tmax) of glucagon (defined in np/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Area Under the Curve (AUC) of CCK
Description
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Maximum Plasma Concentration (Cmax) of CCK
Description
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 0
Title
Time of Maximum Plasma Concentration (Tmax) of CCK
Description
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Area Under the Curve (AUC) of CCK
Description
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Maximum Plasma Concentration (Cmax) of CCK
Description
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 7
Title
Time of Maximum Plasma Concentration (Tmax) of CCK
Description
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 7
Title
Area Under the Curve (AUC) of CCK
Description
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Maximum Plasma Concentration (Cmax) of CCK
Description
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Time of Maximum Plasma Concentration (Tmax) of CCK
Description
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 14
Title
Area Under the Curve (AUC) of CCK
Description
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 21
Title
Maximum Plasma Concentration (Cmax) of CCK
Description
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
Day 21
Title
Time of Maximum Plasma Concentration (Tmax) of CCK
Description
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 21
Title
Area Under the Curve (AUC) of CCK
Description
Area Under the Curve (AUC) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Maximum Plasma Concentration (Cmax) of CCK
Description
Maximum Plasma Concentration (Cmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Time of Maximum Plasma Concentration (Tmax) of CCK
Description
Time of Maximum Plasma Concentration (Tmax) of CCK (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 28
Title
Area Under the Curve (AUC) of Grehlin
Description
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Maximum Plasma Concentration (Cmax) of Grehlin
Description
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
Day 0
Title
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Description
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of Grehlin
Description
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of Grehlin
Description
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Description
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Area Under the Curve (AUC) of Grehlin
Description
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of Grehlin
Description
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Description
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Area Under the Curve (AUC) of Grehlin
Description
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of Grehlin
Description
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Description
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of Grehlin
Description
Area Under the Curve (AUC) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of Grehlin
Description
Maximum Plasma Concentration (Cmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of Grehlin
Description
Time of Maximum Plasma Concentration (Tmax) of Grehlin (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Area Under the Curve (AUC) of leptin
Description
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of leptin
Description
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of leptin
Description
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of leptin
Description
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of leptin
Description
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of leptin
Description
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Area Under the Curve (AUC) of leptin
Description
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of leptin
Description
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of leptin
Description
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Area Under the Curve (AUC) of leptin
Description
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of leptin
Description
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of leptin
Description
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of leptin
Description
Area Under the Curve (AUC) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of leptin
Description
Maximum Plasma Concentration (Cmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of leptin
Description
Time of Maximum Plasma Concentration (Tmax) of leptin (defined in ng/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Area Under the Curve (AUC) of GLP1
Description
Area Under the Curve (AUC) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of GLP1
Description
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of GLP1
Description
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of GLP1
Description
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of GLP1
Description
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of GLP1
Description
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Area Under the Curve (AUC) of GLP1
Description
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of GLP1
Description
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of GLP1
Description
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Area Under the Curve (AUC) of GLP1
Description
Area Under the Curve (AUC) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of GLP1
Description
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of GLP1
Description
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of GLP1
Description
Area Under the Curve (AUC) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of GLP1
Description
Maximum Plasma Concentration (Cmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of GLP1
Description
Time of Maximum Plasma Concentration (Tmax) of GLP1 (defined in pmol /L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Area Under the Curve (AUC) of incretines
Description
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of incretines
Description
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of incretines
Description
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of incretines
Description
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of incretines
Description
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of incretines
Description
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Area Under the Curve (AUC) of incretines
Description
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of incretines
Description
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of incretines
Description
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Area Under the Curve (AUC) of incretines
Description
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of incretines
Description
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of incretines
Description
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Area Under the Curve (AUC) of incretines
Description
Area Under the Curve (AUC) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of incretines
Description
Maximum Plasma Concentration (Cmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of incretines
Description
Time of Maximum Plasma Concentration (Tmax) of incretines (defined in pg/mL) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Area Under the Curve (AUC) of insulin
Description
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of insulin
Description
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of insulin
Description
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of insulin
Description
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of insulin
Description
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of insulin
Description
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Area Under the Curve (AUC) of insulin
Description
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of insulin
Description
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of insulin
Description
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Area Under the Curve (AUC) of insulin
Description
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of insulin
Description
Maximum Plasma Concentration (Cmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of insulin
Description
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of insulin
Description
Area Under the Curve (AUC) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of insulin
Description
Time of Maximum Plasma Concentration (Tmax) of insulin (defined in µg/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Area Under the Curve (AUC) of urea
Description
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 0
Title
Time of Maximum Plasma Concentration (Tmax) of urea
Description
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 0
Title
Area Under the Curve (AUC) of urea
Description
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 7
Title
Time of Maximum Plasma Concentration (Tmax) of urea
Description
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 7
Title
Area Under the Curve (AUC) of urea
Description
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 14
Title
Time of Maximum Plasma Concentration (Tmax) of urea
Description
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 14
Title
Area Under the Curve (AUC) of urea
Description
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 21
Title
Time of Maximum Plasma Concentration (Tmax) of urea
Description
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 21
Title
Area Under the Curve (AUC) of urea
Description
Area Under the Curve (AUC) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Maximum Plasma Concentration (Cmax) of urea
Description
Maximum Plasma Concentration (Cmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste.
Time Frame
day 28
Title
Time of Maximum Plasma Concentration (Tmax) of urea
Description
Time of Maximum Plasma Concentration (Tmax) of urea (defined in mmol/L) between T0 and T120 minutes following ingestion of fruit paste
Time Frame
day 28
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 0 after ingestion in Day 0
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Time Frame
at time 60 after ingestion in Day 0
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 180 after ingestion in Day 0
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Time Frame
at time 0 after ingestion in Day 7
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Time Frame
at time 60 after ingestion in Day 7
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 180 after ingestion in Day 7
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 0 after ingestion in Day 14
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Time Frame
at time 60 after ingestion in Day 14
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry
Time Frame
at time 180 after ingestion in Day 14
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 0 after ingestion in Day 21
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 60 after ingestion in Day 21
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 180 after ingestion in Day 21
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 0 after ingestion in Day 28
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 60 after ingestion in Day 28
Title
Questionnaire of satiety
Description
Questionnaire was composed of 4 questions where satiety was assessed by a 0-10 Numerical Satiety Rating Scale where "0" means to be free from hunger and "10" to be very hungry.
Time Frame
at time 180 after ingestion in Day 28
Title
Questionnaire of acceptability
Description
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Time Frame
day 0
Title
Questionnaire of acceptability
Description
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Time Frame
day 7
Title
Questionnaire of acceptability
Description
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Time Frame
day 14
Title
Questionnaire of acceptability
Description
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Time Frame
day 21
Title
Questionnaire of acceptability
Description
Acceptability was assessed by a 7-point time scale where "1" means a very poor acceptability and "7" means a very good acceptability
Time Frame
day 28
Title
Facilited individual interview
Description
Facilitated interview to assess organoleptic, satiety and gastrointestinal comfort
Time Frame
day 40
Title
Focus group
Description
Focus group interview to assess organoleptic, satiety and gastrointestinal comfort
Time Frame
day 40

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Male subject Subject over 65 years (included) Subject over 61 kg (included) Able to consume the 80g of fruit pastes in 10 minutes Subject with a dentition consistent with the fruit paste consumption in 10 minutes Subject with a Body Mass Index (BMI) between 21 and 30 kg/m2 Subject agreeing to provide written consent Exclusion Criteria: Subject with acute pathology (unstable or terminal pathology, severe dementia) Subject with renal failure (clearance < 60 ml/min) Subject with metabolic syndrome (3 of the following 5 criteria: waist greater than 94 cm, blood triglyceride greater than 1.7 mmol/l, blood pressure greater than or equal to 130 mm Hg/85 mm Hg, cholesterol (HDL) less than 1.0 mmol/l in men, blood glucose greater than or equal to 5.6 mmol/l) Person with diabetes Subject on food restriction Subject undergoing chemotherapy Subject with gastrointestinal pathology Subject in a diet incompatible with the nutritional protocol (gluten, lactose or milk intolerance, vegan)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Gisèle Pickering
Organizational Affiliation
University Hospital, Clermont-Ferrand
Official's Role
Principal Investigator
Facility Information:
Facility Name
CHU de Clermont-Ferrand
City
Clermont-Ferrand
ZIP/Postal Code
63000
Country
France

12. IPD Sharing Statement

Learn more about this trial

Food Matrices Based on Fruit Pastes as Vectors of Carbohydrates for the Prevention and Management of Protein-energy Undernutrition in the Elderly (Fruisenior)

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