Forodesine (BCX-1777) in Treating Patients With Refractory Stage IIA, Stage IIB, Stage III, Stage IVA, or Stage IVB Cutaneous T-Cell Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring recurrent cutaneous T-cell non-Hodgkin lymphoma, stage II cutaneous T-cell non-Hodgkin lymphoma, stage III cutaneous T-cell non-Hodgkin lymphoma, stage IV cutaneous T-cell non-Hodgkin lymphoma, recurrent mycosis fungoides/Sezary syndrome, stage II mycosis fungoides/Sezary syndrome, stage III mycosis fungoides/Sezary syndrome, stage IV mycosis fungoides/Sezary syndrome
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed cutaneous T-cell lymphoma Refractory to prior treatment Stage IIA, IIB, III, IVA, or IVB disease Measurable disease PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-2 Life expectancy At least 3 months Hematopoietic Not specified Hepatic AST and/or ALT ≤ 3 times upper limit of normal Hepatitis B and/or hepatitis C negative Renal Creatinine clearance ≥ 40 mL/min Immunologic Human T-cell lymphotrophic virus type I (HTLV-I) negative HIV negative No active serious infection not controlled by antibiotics Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No known impaired absorption of the gastrointestinal tract No other illness that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy More than 21 days since prior chemotherapy and recovered Endocrine therapy Concurrent topical corticosteroids allowed provided patient remains on a stable dose Radiotherapy No concurrent radiotherapy Surgery Not specified Other More than 30 days since prior investigational agents and recovered No concurrent tanning bed use No other concurrent therapy for cutaneous T-cell lymphoma
Sites / Locations
- Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham
- Burke Pharmaceutical Research
- Stanford Comprehensive Cancer Center - Stanford
- University of Colorado Cancer Center at UC Health Sciences Center
- Yale Cancer Center
- Cancer and Blood Disease Center
- Dana-Farber/Brigham and Women's Cancer Center
- Duke Comprehensive Cancer Center
- Charles M. Barrett Cancer Center at University Hospital
- M.D. Anderson Cancer Center at University of Texas