Frequency Domain Optical Imaging
Breast Cancer
About this trial
This is an interventional basic science trial for Breast Cancer
Eligibility Criteria
HEALTHY VOLUNTEERS
Inclusion Criteria:
- Female, ≥20 years old
- Breast size and epithelial integrity adequate to allow NIR imaging exams.
- Ability to provide written informed consent
- No serious associated psychiatric illnesses.
Exclusion Criteria:
Absolute or relative contraindication to MRI:
- the presence of an electronic implant, such as a pacemaker
- the presence of a metal implant, such as an aneurysm clip
- claustrophobia
- the presence of other contraindication(s), as determined by the MRI technologists and radiologists.
- Pregnancy
WOMEN WITH BREAST ABNORMALITIES
Inclusion:
- Female, ≥ 20 years old.
- Breast size and epithelial integrity adequate to allow NIR imaging exams.
- Ability to provide written informed consent.
- No serious associated psychiatric illnesses.
- A recent screening mammogram that questions the presence of an abnormality, thus requiring further mammographic examination.
Exclusion:
Absolute or relative contraindication to MRI:
- the presence of an electronic implant, such as a pacemaker
- the presence of a metal implant, such as an aneurysm clip
- claustrophobia
- the presence of other contraindication(s), as determined by the MRI technologists and radiologists.
- Pregnancy
- A history of allergy to iodides
- A GFR < 30 ml/min as determined by blood test on the day of NIR/MR imaging, or from lab results within 3 months of NIR/MR imaging.
Sites / Locations
Arms of the Study
Arm 1
Other
MR-guided NIR
Women with breast abnormalities will undergo an "optical exam" (NIR) in combination with MRI where the NIR light imaging system illuminates the breast from multiple positions covering the area of interest. A total of 60 women will be evaluated: 20 with breast abnormalities receiving gadolinium (Gd) contrast enhancement, 20 with breast abnormalities receiving both Gd-contrast enhancement and indocyanine green (ICG) contrast enhancement, and 20 healthy volunteers not receiving any contrast agents.