FT538 in Subjects With Advanced Hematologic Malignancies
Acute Myeloid Leukemia, AML, Adult, Multiple Myeloma
About this trial
This is an interventional treatment trial for Acute Myeloid Leukemia focused on measuring Acute Myeloid Leukemia, AML, Multiple Myeloma, daratumumab, elotuzumab, NK cell, cellular therapy, allogeneic cell therapy, allogeneic cellular therapy, CD38, Anti-CD38
Eligibility Criteria
Inclusion Criteria:
Diagnosis of one of the following by treatment regimen:
Regimen A (FT538 monotherapy in r/r AML)
- Primary refractory AML, or
- Relapsed AML, defined as not in CR after one or more re-induction attempts; if >60 years of age, prior re-induction therapy is not required
Regimens B or C (FT538 + mAb in r/r MM)
- Regimen B only: MM that has relapsed or progressed after at least two lines of therapies, including a proteasome inhibitor and an immunomodulatory drug
- Regimen C only: MM that has relapsed or progressed after proteasome inhibitor therapy, and immunomodulatory therapy
- Regimen B and Regimen C: Measurable disease as defined in the protocol
- Capable of giving signed informed consent
- Age ≥18 years old
- Agreement to comply with study procedures as described in the Schedule of Activities
- Contraceptive use as described in the protocol
Exclusion Criteria:
- Females who are pregnant or breastfeeding
- ECOG Performance Status ≥ 2
- Evidence of insufficient hematologic function as defined in the protocol
- Evidence of insufficient organ function defined as defined by the protocol
- Clinically significant cardiovascular disease as defined by the protocol
- Known active central nervous system (CNS) involvement by malignancy
- Non-malignant CNS disease such as stroke, epilepsy, CNS vasculitis, or neurodegenerative disease or receipt of medications for these conditions in the 2-year period leading up to study enrollment
- Currently receiving or likely to require systemic immunosuppressive therapy for any reason during the treatment period
- Clinically significant infections including HIV, HBV and HCV
- Live vaccine <6 weeks prior to start of lympho-conditioning
- Receipt of an allograft organ transplant
- Prior allogeneic HSCT or allogeneic CAR-T within 6 months of Day 1, or ongoing requirement for systemic graft-versus-host therapy
- Known allergy to albumin (human) or DMSO
- Presence of any medical or social issues that are likely to interfere with study conduct or may cause increased risk to subject
Any medical condition or clinical laboratory abnormality that per investigator or Medical Monitor judgement precludes safe participation in and completion of the study, or which could affect compliance with protocol conduct or interpretation of results
Exclusion Criteria Specific to Regimen A (r/r AML)
- Diagnosis of promyelocytic leukemia with t(15;17) translocation
Receipt of any biological therapy, chemotherapy, or radiation therapy, except for palliative purposes, within 2 weeks prior to Day 1 or five half-lives, whichever is shorter; or any investigational therapy within 28 days prior to Day 1
Exclusion Criteria Specific to Regimens B and C (r/r MM)
- Plasma cell leukemia defined as a plasma cell count >2000/mm3
- Leptomeningeal involvement of MM
- Receipt of any biological therapy, chemotherapy, or radiation therapy, except for palliative purposes, within 2 weeks prior to Day 1 or five half-lives, whichever is shorter; or any investigational therapy within 28 days prior to the first dose of mAb
- Allergy or hypersensitivity to antibodies or antibody-related proteins
Sites / Locations
- Colorado Blood Cancer Institute
- University of Minnesota Masonic Cancer Center
- Washington University
- Memorial Sloan Kettering Cancer Center
- Sarah Cannon Research Institute at Tennessee Oncology
- St. David's South Austin Medical Center
- MD Anderson Cancer Center
- Texas Transplant Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
FT538 Monotherapy
FT538 in Combination with Daratumumab
FT538 in Combination with Elotuzumab
FT538 monotherapy in subjects with r/r AML
FT538 in combination with daratumumab in subjects with r/r MM
FT538 in combination with elotuzumab in subjects with r/r MM