Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy
Essential Tremor
About this trial
This is an interventional treatment trial for Essential Tremor focused on measuring focused ultrasound, fMRI
Eligibility Criteria
Inclusion Criteria:
- The tremor diagnosis, disability and medically refractory status are agreed upon by at least two movement disorder trained physicians (neurologists and/or neurosurgeons).
- The patient is deemed suitable for surgical therapy for tremor with VIM targeting.
- The patient is willing to participate in the study and provides written informed consent.
- The patient is able to clearly communicate clinical findings with the clinical team.
- The patient is willing to participate in at least one follow-up visit at 3 or 6 months.
- In order to maintain uniformity of image acquisition only patients undergoing imaging with the 3T MRI at The Ohio State University Wexner Medical Center will be included.
Exclusion Criteria:
- Medically unstable - uncontrolled hypertension, coronary artery disease, significant pulmonary problems, active history of bleeding disorders or anticoagulation.
- Other diagnoses of tremor like Parkinson's disease, traumatic tremor, dystonic tremor, and/or tremor associated with multiple sclerosis
- Unwilling or unable to undergo awake tremor surgery.
- Tremor patients undergoing surgery with targets other than the VIM.
- Significant motion artifact in imaging.
- Unable to undergo 3T MRI imaging.
Sites / Locations
- The Ohio State Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
ET cohort
control cohort
Ten adults with refractory ET (ET cohort) will undergo multi-modality neuroimaging (structural imaging, diffusion tensor imaging (DTI), task-based functional MRI (t-fMRI), and resting state functional MRI (rs-fMRI)). In addition the ET cohort will also undergo imaging with the identical protocol immediately after and 24 hours after FUS-T.
Twenty adult healthy controls (control cohort) will undergo multi-modality neuroimaging (structural imaging, diffusion tensor imaging (DTI), task-based functional MRI (t-fMRI), and resting state functional MRI (rs-fMRI)).