Gemcitabine and Radiation Therapy Compared With Gemcitabine Alone in Treating Patients Who Have Undergone Surgery for Pancreatic Cancer
Pancreatic Cancer
About this trial
This is an interventional treatment trial for Pancreatic Cancer focused on measuring adenocarcinoma of the pancreas, stage I pancreatic cancer, stage II pancreatic cancer, stage III pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed pancreatic head adenocarcinoma Prior pancreaticoduodenectomy required Documented histological examination of surgical margins (R0), including retroperitoneal margin Performed within the past 8 weeks Any number of lymph nodes (less than 10 OR 10 or more) allowed No periampullary cancer PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-2 OR WHO 0-2 Life expectancy Not specified Hematopoietic WBC greater than 3,500/mm^3 Platelet count greater than 150,000/mm^3 Hemoglobin greater than 9.0 g/dL Hepatic Bilirubin less than 1.5 times normal AST and ALT less than 3.0 times normal Renal Creatinine less than 1.2 mg/dL Other Not pregnant or nursing Fertile patients must use effective contraception No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix No psychological, familial, sociological, or geographical condition that would preclude study compliance and follow-up PRIOR CONCURRENT THERAPY: Biologic therapy No concurrent immunotherapy Chemotherapy No prior chemotherapy No other concurrent chemotherapy Endocrine therapy Not specified Radiotherapy No prior radiotherapy Surgery See Disease Characteristics Recovered from prior surgery Other No other concurrent anticancer agents
Sites / Locations
- Hopital Universitaire Erasme
- Universitair Ziekenhuis Gent
- Hopital de Jolimont
- Cazk Groeninghe - Campus St-Niklaas
- CHU Liege - Domaine Universitaire du Sart Tilman
- Algemeen Ziekenhuis Sint-Augustinus
- Centre Hospitalier d'Abbeville
- Centre Hospitalier d'Annecy
- Institut Sainte Catherine
- Hopital Duffaut
- C.H.G. Beauvais
- Centre Hospitalier de Blois
- Clinique Tivoli
- Polyclinique Bordeaux Nord Aquitaine
- Centre Hospitalier Universitaire Ambroise Pare - Boulogne
- Centre Hospitalier Docteur Duchenne
- Centre Hospitalier Pierre Oudot
- CHU de Caen
- CHR Clermont Ferrand, Hotel dieu
- Hopital Beaujon
- Louis Mourier Hospital
- Centre Hospitalier Universitaire Henri Mondor
- Centre Hospitalier de Dax
- Hopital Du Bocage
- Centre Hospitalier Intercommunal St. Aubin les Elbeuf
- CHU de Grenoble - Hopital de la Tronche
- Centre Hospitalier Departemental
- Clinique Victor Hugo
- Hopital Robert Boulin
- Centre Hospital Regional Universitaire de Limoges
- Clinique Saint Jean
- Centre Leon Berard
- CHU de la Timone
- Centre Hospitalier General de Mont de Marsan
- Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
- Centre Hospitalier de Mulhouse
- C.H.U. de Nimes - Groupe Hospitals-Universitaire Caremeau
- Hopital Europeen Georges Pompidou
- Hopital Bichat - Claude Bernard
- Hopital Saint Antoine
- CHU Pitie-Salpetriere
- Hopital Cochin
- Hopital Tenon
- C.H.G. De Pau
- Centre Hospitalier Lyon Sud
- CHU Poitiers
- Hopital Charles Nicolle
- Centre Paul Strauss
- Hopital Universitaire Hautepierre
- Centre Hospitalier Universitaire Bretonneau de Tours
- Centre Alexis Vautrin
- Charite - Campus Charite Mitte
- Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch
- Universitaetsklinikum Duesseldorf
- Johannes Gutenberg University
- Munich Oncologic Practice at Elisenhof
- Rambam Medical Center
- Academisch Medisch Centrum at University of Amsterdam
- Hopital Cantonal Universitaire de Geneve