Gemcitabine and Topotecan in Treating Patients With Recurrent or Persistent Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer
Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
About this trial
This is an interventional treatment trial for Fallopian Tube Cancer focused on measuring recurrent ovarian epithelial cancer, fallopian tube cancer, peritoneal cavity cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of ovarian, fallopian tube, or primary peritoneal cavity cancer Recurrent or persistent platinum-refractory disease, as defined by 1 of the following: Progressive disease while on a platinum compound Persistent clinically measurable disease with best response as stable disease at the completion of ≥ 6 courses of therapy Recurrent disease within 6 months after completion of therapy Measurable or evaluable disease Evaluable disease, defined as CA 125 ≥ 100 U/mL (confirmed by 2 blood tests) Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques, including palpation, plain x-ray, CT scan, or MRI, OR ≥ 10 mm by spiral CT scan PATIENT CHARACTERISTICS: Age 18 and over Performance status GOG 0-3 Life expectancy Not specified Hematopoietic Absolute neutrophil count ≥ 1,500/mm^3 Platelet count ≥ 100,000/mm^3 Hepatic Bilirubin ≤ 1.5 times upper limit of normal (ULN) SGOT ≤ 2.5 times ULN Alkaline phosphatase ≤ 2.5 times ULN Renal Creatinine ≤ 1.5 times ULN Creatinine clearance > 50 mL/min Other No clinically significant infection No other severe medical condition that would preclude study treatment No other malignancy within the past 5 years except nonmelanoma skin cancer or carcinoma in situ of the cervix or breast PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics Prior gemcitabine or topotecan allowed provided disease is not refractory to either drug At least 3 weeks since prior chemotherapy and recovered Endocrine therapy Not specified Radiotherapy At least 3 weeks since prior radiotherapy and recovered Surgery Recovered from recent prior surgery
Sites / Locations
- University of Washington School of Medicine