Gene Therapy in HIV-Positive Patients With Non-Hodgkin's Lymphoma
Lymphoma, Non-Hodgkin, HIV Infections
About this trial
This is an interventional treatment trial for Lymphoma, Non-Hodgkin focused on measuring Lymphoma, Non-Hodgkin, Bone Marrow, Lymphocyte Transformation, HIV-1, Retroviridae, Lymphoma, AIDS-Related, Genetic Vectors, Transduction, Genetic, Gene Transfer Techniques
Eligibility Criteria
Inclusion Criteria You may be eligible for this study if you: Are 18 to 60 years old. Have been HIV-positive at least since you were diagnosed with non-Hodgkin's lymphoma. Have an HIV level less than or equal to 25,000 copies/ml and a CD4 count of at least 100 cells/mm3. Are currently about to undergo bone marrow transplantation. Have responded well to cancer treatments, including chemotherapy and previous bone marrow transplantation. Agree to use effective barrier methods of birth control, such as condoms, during the study. Are on anti-HIV therapy (HAART). Exclusion Criteria You will not be eligible for this study if you: Have lymphoma affecting your nervous system. Have had any AIDS-related opportunistic infections in the past year. Have heart disease. Are pregnant or breast-feeding. Have severe diarrhea. Have a history of cytomegalovirus (CMV) retinitis. Have dementia or encephalopathy (an infection of the brain). Have a history of another type of cancer (except for skin cancer) before your diagnosis of NHL. Are allergic to etoposide or have had a toxic reaction to prior chemotherapy.
Sites / Locations
- City of Hope Natl Med Ctr