Half-Dose Radiopharmaceutical in Wide Beam Reconstruction (REGA-1102)
Myocardial Infarction, Ischemic Heart Disease
About this trial
This is an interventional diagnostic trial for Myocardial Infarction focused on measuring SPECT MPI, Tomography, Emission-Computed, Single-Photon, Wide Beam Reconstruction
Eligibility Criteria
Inclusion Criteria:
- Patients over the age of 18 years
- Undergoing nuclear stress testing
- History of myocardial infarction, cardiomyopathy, heart failure or prior nuclear studies with resting perfusion defects
Exclusion Criteria:
- Unwilling or unable to undergo an additional resting SPECT acquisition
Clinical contraindications to nuclear stress testing including acute myocardial infarction
- For patients undergoing exercise treadmill stress testing:
Left bundle branch block or artificial ventricular pacemaker
- For patients undergoing regadenoson (Lexiscan) stress testing:
- Moderate to severe chronic obstructive pulmonary disease or asthma, second- or third degree atrioventricular block or sinus node disease (unless patients have a functioning artificial pacemaker), known hypersensitivity to aminophylline or adenosine
- Inability to give informed consent
Sites / Locations
- Northwestern University
Arms of the Study
Arm 1
Experimental
Half-dose radiotracer administration
For this study, researchers would like to administer half of the radiotracer, obtain resting images, administer the remainder of the radiotracer and obtain a second set of resting images. Subjects will be given the same amount of radioactive material that would normally be given for this test; however, it will be administered in two ½ doses.