Heartrate and Breathing Effects on Attention and Memory (HeartBEAM)
Aging, Alzheimer Disease, Age-related Cognitive Decline
About this trial
This is an interventional basic science trial for Aging
Eligibility Criteria
Inclusion Criteria: speak English fluently between the age of 50-70 healthy adult who weighs at least 110 pounds non-pregnant and non-menstruating (for at least the past year) normal or corrected-to-normal vision and hearing have a home computer with a physical keyboard and have access to reliable internet have an email account that you check regularly have a phone that receives text messages willing to provide a blood sample and a urine sample at three lab visits willing to devote up to 60 minutes daily to the study for 12 weeks (in addition to lab visits) Exclusion Criteria: have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, heart disease including coronary artery disease, angina, and arrhythmia, cognitive impairment, dyspnea) regularly practicing any relaxation, biofeedback, or breathing technique (e.g., meditation) for more than an hour a week regularly played Lumosity games in the past 6 months participated in heart rate biofeedback studies in the USC Emotion & Cognition Lab have any conditions listed below that are not safe for MRI Claustrophobia Have worked as a machinist, metal worker, or in any profession or hobby grinding metal? Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) Cardiac pacemaker Implanted cardiac defibrillator Aneurysm clip or brain clip Carotid artery vascular clamp Neurostimulator Insulin or infusion pump Spinal fusion stimulator Cochlear, otologic, ear tubes or ear implant Prosthesis (eye/orbital, penile, etc.) Implant held in place by a magnet Heart valve prosthesis Artificial limb or joint Other implants in body or head Electrodes (on body, head or brain) Intravascular stents, filters Shunt (spinal or intraventricular) Vascular access port or catheters IUD Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI Shrapnel, buckshot, or bullets Tattooed eyeliner or eyebrows Body piercing(s) that cannot be removed for MRI Metal fragments (eye, head, ear, skin) Internal pacing wires Aortic clips Metal or wire mesh implants Wire sutures or surgical staples Harrington rods (spine) Bone/joint pin, screw, nail, wire, plate Wig or toupee that cannot be removed for MRI Hair implants that involve staples or metal Hearing aid(s) that cannot be removed for MRI Dentures or retainers that cannot be removed for MRI
Sites / Locations
- University of Southern CaliforniaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Brain training and paced breathing to stimulate alertness
Brain training and paced breathing to relax