Heat Therapy, Functional Capacity, and Vascular Health in Older Adults
Aging Well, Walking, Difficulty, Hyperemia
About this trial
This is an interventional basic science trial for Aging Well focused on measuring Healthy aging, Functional capacity, Exercise hyperemia, Vascular function, heat therapy
Eligibility Criteria
Inclusion Criteria: 55 to 80 years of age No tobacco/nicotine use within preceding 6 months (e.g., cigarettes, chewing tobacco, nicotine gum or patches, and vapor smoking) Systolic blood pressure <140 mmHg; diastolic blood pressure <90 mmHg Normal 12-lead ECG (reviewed by a physician) Normal clinical results from a medical exam reviewed by a board-certified physician (e.g., General Health Questionnaire - see attached document) Body mass index (BMI) <35 unless athletic/muscular build; calculation = body weight (kg)/height (m2) Females Only: Post-menopausal Exclusion Criteria: Not meeting the age criteria Body mass index (BMI) >35 unless athletic/muscular build; calculation = body weight (kg)/height (m2) Use of tobacco or nicotine products within the last 6 months (tobacco cigarettes, chewing tobacco, nicotine patches or gum) Not abstaining from the following 24 hours prior to the experimental session: exercise, alcoholic substances, prescription or non-prescription medications (unless cleared by the medical screener), dietary supplements, herbal medications, caffeinated substances (including chocolate, coffee, tea (iced or hot), caffeinated energy drinks, and sodas) S who weigh less than 80 lbs Use of prescription drugs, non-prescription drugs or herbal medicines known to alter vascular function unless cleared prior to the study Use of anti-hypertensive medications Use of beta blockers Daily use of bronchodilators Current use of anti-coagulant therapy Current use of hormone replacement therapy (e.g., estrogen, testosterone) Current diagnosis of cancer Signs of overt cardio-metabolic abnormalities (e.g., uncontrolled diabetes - HbA1c >7.5, a resting systolic blood pressure >140mmHg or diastolic blood pressure >90mmHg; abnormal 12-lead ECG) History of cerebrovascular abnormalities (e.g., prior stroke, transient ischemic attacks, epilepsy, increased intracranial pressure) Known history of atherosclerosis (i.e., plaque formation) Autonomic dysfunction (e.g., Shy-Drager Syndrome, Bradbury-Eggleston syndrome, idiopathic orthostatic hypotension) Respiratory illnesses (e.g., chronic asthma (including exercise-induced asthma), Chronic Obstructive Pulmonary Disease, Reactive Airway Disease). Note: subjects with exercised-induced asthma or who have had COVID-19 will be allowed to participate History of anaphylaxis Severe phobia of needles History of alcohol or drug abuse which inhibits the participants ability to complete this study Latex allergy Known allergies or sensitivities to drugs used in the study (e.g., Lidocaine HCL, acetylcholine HCL, sodium nitroprusside, nitroglycerin, or related drugs) Implanted electronic medical devices (e.g. cardiac pacemaker) Tissue or skin abnormalities of the legs (e.g., infection, injury, open wound, ischemic tissue, phlebitis, active bleeding, neuropathy) Tissue or skin abnormalities of the arm (e.g., unhealed or open wound or circulatory deficits) Current Fever (oral temp >99.5 °F/ 37.5 °C) aa) Current use of PDE3 inhibitors (e.g., Viagra) or soluble guanylate cyclase (sGC) stimulators (e.g., riociguat), or unwillingness to withhold medication for 2 weeks prior to laboratory testing bb) Diagnosis of neurological disease or cognitive dysfunction cc) Cardiac surgery or cardiac events (e.g., coronary artery bypass graft surgery, myocardial infarction, heart failure) dd) Abnormal clotting, clots in deep veins in the legs or pelvis, or blood clots to the lungs ee) Individuals who have had mastectomies ff) History of methemoglobinemia
Sites / Locations
- University of North Texas Health Science CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Home-based heat therapy and functional capacity in older adults
Home-based heat therapy and vascular function and exercise hyperemia in older adults
The investigators will determine the extent to which home-based leg heat therapy improves functional capacity in older adults. Functional capacity will be assessed before and after heat therapy or sham intervention via the 6-min walk test and the Short Physical Performance Battery.
The investigators will determine if home-based leg heat therapy improves vascular function and exercise hyperemia in the older adults of Aim 1. Using state-of-the-art techniques of skeletal muscle microdialysis and high-resolution duplex ultrasound, the investigators will pharmacodissect mechanisms of vascular function and exercise hyperemia before and after each intervention. The outcomes of Aim 2, while providing insight into the mechanisms whereby heat therapy improves functional capacity, should be considered independent of the outcomes of Aim 1 given that vascular health is a key independent, yet modifiable risk factor for cardiovascular morbidity and mortality.