Heparin Intraoperative Instillation for Lower Urinary Tract Symptoms After Benign Hysterectomy (HILUTS)
Lower Urinary Tract Symptoms, Postoperative Urinary Tract Infection
About this trial
This is an interventional prevention trial for Lower Urinary Tract Symptoms focused on measuring Randomized controlled trial, Heparin instillation
Eligibility Criteria
Inclusion Criteria:
- 18 to 85-years old
- scheduled to undergo a benign hysterectomy
Exclusion Criteria:
- non-English speakers
- current use of anticoagulants or thrombolytic agents
- known adverse reaction or hypersensitivity to heparin
- history of or active genitourinary tract cancer (bladder, uterine, cervical, ovarian or vaginal)
- history of neurogenic bladder
- pelvic irradiation
- chemical cystitis
- pregnancy
- antibiotic use within the past 30 days
- Surgical procedures involving: anterior or posterior colporrhaphy, vaginal mesh excision, fistula repair, diverticulum repair, urethral reconstruction, planned or incidental cystotomy
Sites / Locations
- The Christ HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Heparin Bladder Instillation
Normal Saline Bladder Instillation
At the completion of the scheduled benign hysterectomy, intravesicular bladder instillation containing 40,000U of heparin (40mL of 10,000U heparin/10mL) will be administered be introduced in a retrograde fashion by gravity via Foley catheter. The Foley catheter will be clamped for 30 minutes approximately 1cm from the vaginal opening.
Patients randomized to the control group will undergo intravesical instillation with 40mL of normal saline. The Foley catheter will be clamped for 30 minutes approximately 1cm from the vaginal opening.