Home-based Action Observation Treatment With Virtual-reality for Arm Rehabilitation in People With Multiple Sclerosis
Multiple Sclerosis
About this trial
This is an interventional treatment trial for Multiple Sclerosis
Eligibility Criteria
Inclusion Criteria: Age 18-65 years; Diagnosis of MS according to 2017 revised McDonald criteria; Ability to understand the purpose and risks of the study and provide signed informed consent; Ability to remotely perform VR-AOT; Right pre-morbid handedness (EHI>50); Muscle strength deficit involving the right upper limb (≥1 point decrease of MRC scale); Presence of activity limitation of the right hand (need of adaptations, supervision or help by another person for the execution of daily living activities according to items 1-6 of the FIM); EDSS score 2.0-7.0 (inclusive); Cerebellar functional system score of the EDSS ≤1; Baseline 9HPT score >21 seconds and <180 seconds. Exclusion Criteria: MRI contraindications; Significant visual deficits not allowing to observe VR stimuli; Moderate to severe pain disturbances (VAS≥4); Concomitant neuro-psychiatric or systemic diseases (other than MS); Clinical relapses or steroid treatment in the past 3 months; Modification of symptomatic treatment or botulin toxin injection in the upper limb in the past 3 months; Stable disease-modifying treatment for MS for ≤6 months; Rehabilitation treatment in the past 3 months.
Sites / Locations
- IRCCS San RaffaeleRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
VR-AOT
VR-LO
Home-based Action Observation Treatment with virtual-reality for upper limb rehabilitation
Home-based landscape observation with virtual-reality for upper limb rehabilitation