Honey or Olive Oil for Treating Oral Mucositis in Children and Adults With Leukemia Receiving Intensive Chemotherapy
Oral Mucositis, Leukemia
About this trial
This is an interventional prevention trial for Oral Mucositis focused on measuring honey, olive oil, oral mucositis, pain
Eligibility Criteria
Inclusion Criteria:
The following are the inclusion criteria:
- Children/Adults with leukemia (ALL, AML) receiving intensive (high dose) chemotherapy treatment such as myeloablative, doxorubicin or methotrexate during induction, consolidation and re-induction therapy.
- Absence of any home remedy for mucositis
- Patients with grades 1-3 OM based on the WHO grading system.
Exclusion Criteria:
- Patients under non- intensive chemotherapeutic treatment.
- Presence of advanced or severe periodontitis (patients with periodontal pockets of 6mm or more).
- Patients with a cognitive disability which my no enable them to assess their pain
- History of allergy to honey or olive oil.
Sites / Locations
- American Univeristy of Beirut Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
group 1
Group 2
Group 3
Efficacy of Manuka honey on severity and pain of OM compared to placebo (standard care) and to assess which of the two interventions is more beneficial.
Efficacy of olive oil on severity and pain of OM compared to placebo (standard care) and to assess which of the two interventions is more beneficial.
The control group at our institution is 5cc sodium bicarbonate, 5cc rinsidin and 5cc of mycostatin 4 times daily for children. For adults it is Caphosol in the BMT unit and in the Basile inpatient unit it is the magic solution (without xylocaine