Hormone Replacement Therapy and the Risk of Breast Cancer Recurrence in Women With Previous Early Stage Breast Cancer
Breast Cancer, Menopausal Symptoms
About this trial
This is an interventional supportive care trial for Breast Cancer focused on measuring menopausal symptoms, stage I breast cancer, stage II breast cancer, breast cancer in situ
Eligibility Criteria
DISEASE CHARACTERISTICS: History of stage 0-II breast cancer with no more than 4 involved axillary nodes if nodal status and number of nodes investigated is known No current evidence of disease Hormone receptor status: Positive, negative, or unknown PATIENT CHARACTERISTICS: Age: Not specified Sex: Female Menopausal status: Menopausal or perimenopausal Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: No active liver disease Renal: Not specified Cardiovascular: No prior or concurrent deep vein thrombosis No hereditary traits for deep vein thrombosis No prior or concurrent cerebral stroke No prior or concurrent coronary disease Other: No prior malignancy except basal cell skin cancer or carcinoma in situ of the cervix No porphyria No other serious disease that would prevent compliance or greatly limit life expectancy PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No concurrent chemotherapy Endocrine therapy: Prior hormone replacement therapy (HRT) allowed if stopped no more than 4 weeks after breast cancer diagnosis and at least 3 months prior to study No prior HRT initiated after breast cancer diagnosis No concurrent hormonal therapy for breast cancer except tamoxifen or toremifene Radiotherapy: No concurrent radiotherapy Surgery: Not specified Other: No prior randomization into trials comparing effects of chemotherapy and bilateral oophorectomy in premenopausal women
Sites / Locations
- Helsinki University Central Hospital
- Norwegian Radium Hospital
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
- Karolinska Hospital
- Uppsala University Hospital
- Breast Center