Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) (TAILORx)
Breast Adenocarcinoma, Hormone Receptor Positive, Stage IA Breast Cancer AJCC v7
About this trial
This is an interventional treatment trial for Breast Adenocarcinoma
Eligibility Criteria
Inclusion Criteria: Patients with operable histologically confirmed adenocarcinoma of the female breast who have completed primary surgical treatment and meet the following criteria: ER and/or progesterone receptor (PR)-positive: Estrogen and/or progesterone receptor positive disease (as defined by local pathology laboratory) Negative axillary nodes: As assessed by a sentinel lymph node biopsy, an axillary dissection, or both, and as defined by the Sixth Edition of the American Joint Committee on Cancer (AJCC) staging criteria Tumor size 1.1-5.0 cm (or 5 mm-1.0 cm plus unfavorable histological features): Unfavorable features defined as intermediate or poor nuclear and/or histologic grade, or lymphovascular invasion NOTE: Definition of tumor size: The tumor size used for determination of eligibility is the pathologic tumor size, which is usually determined by the size of the tumor as measured by inspection of the gross specimen; if the tumor size is measured microscopically and the tumor includes ductal carcinoma in-situ, the measurement should include only the invasive component of the tumor The tumor must be human epidermal growth factor receptor 2 (Her2)/neu negative by either fluorescent in-situ hybridization (FISH) or immunohistochemistry (e.g. 0 or 1+ by DAKO Herceptest) The patient and physician must be agreeable to initiate standard chemotherapy and hormonal therapy as adjuvant therapy A tissue specimen from the primary breast cancer has been located and is ready to be shipped to the appropriate laboratory after consent is obtained and within 3 days following pre-registration; NOTE: For determination of the Oncotype Recurrence Score, tissue must be shipped to Genomic Health; if the Oncotype DX Recurrence Score was previously performed by Genomic Health (prior to pre-registration), tissue must be submitted to the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility upon randomization Leukocyte count >= 3500/mm^3 Platelets >= 100,000/mm^3 Serum creatinine =< 1.5 mg/dL Serum aspartate transaminase (AST) that is =< 3-fold the upper institutional limits of normal Patients must be disease-free of prior invasive malignancies for >= 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix; patients with a previous ipsilateral or contralateral invasive breast cancer, or with bilateral synchronous cancers, are not eligible; patients with previous ipsilateral or contralateral ductal in situ carcinoma (DCIS) are not eligible Prior treatment Mandatory prior surgery criteria: Patient must pre-register within 84 days from the final surgical procedure required to adequately treat the primary tumor (please note that if margins are not clear and a resection has to be conducted after pre-registration but before randomization, the patient will be deemed to be within the 84 day window allowed by protocol and therefore eligible) All tumors should be removed by either a mastectomy or local excision plus an acceptable axillary procedure (i.e., sentinel lymph node biopsy, axillary dissection, or both); there must be adequate (at least 1 mm if margin width specified) tumor-free margins of resection (for invasive and ductal carcinoma in-situ) in order for the patients to be eligible; patients with lobular carcinoma in-situ involving the resection margins are eligible Criteria re: other prior treatments: No prior chemotherapy for this malignancy No prior radiation therapy for this malignancy; this includes no prior MammoSite Brachytherapy radiation therapy (RT) Hormonal therapy: Patients who develop breast cancer while receiving a selective estrogen-receptor modulator (SERM; e.g., tamoxifen, toremifene, raloxifene) or an aromatase inhibitor (e.g., anastrazole, letrozole, exemestane) for breast cancer prevention or a SERM for other indications (e.g., raloxifene for osteoporosis) are not eligible; however, patients may have received up to 8 weeks of a SERM or aromatase inhibitor for this malignancy and still be eligible for study entry Patients must have an anticipated life expectancy of at least 10 years Patients with the following medical conditions should not be enrolled on the study: Chronic obstructive pulmonary disease requiring treatment Chronic liver disease (e.g., cirrhosis, chronic active hepatitis) Previous history of a cerebrovascular accident History of congestive heart failure or other cardiac disease that would represent a contraindication to the use of an anthracycline (e.g., doxorubicin or epirubicin) Chronic psychiatric condition or other condition that would impair compliance with the treatment regimen Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to pre-registration to rule out pregnancy Women of childbearing potential must be strongly advised to utilize an accepted and effective form of non-hormonal contraception (e.g. intrauterine device, condoms, diaphragm, abstinence) Patients must not have previously had the Oncotype DX Assay performed, with the exception of patients who have had the assay performed and have a recurrence score of 11-25
Sites / Locations
- Northeast Alabama Regional Medical Center
- University of Alabama at Birmingham Cancer Center
- Mobile Infirmary Medical Center
- Providence Hospital
- University of South Alabama Mitchell Cancer Institute
- Alaska Regional Hospital
- Providence Alaska Medical Center
- Fairbanks Memorial Hospital
- Banner Thunderbird Medical Center
- Banner Desert Medical Center
- Banner Baywood Medical Center
- Banner-University Medical Center Phoenix
- Western Regional CCOP
- Virginia G Piper Cancer Care-Del Camino
- Banner University Medical Center - Tucson
- Sparks Regional Medical Center
- Mercy Hospital Fort Smith
- CHI Saint Vincent Cancer Center Hot Springs
- NEA Baptist Memorial Hospital
- Saint Bernards Regional Medical Center
- University of Arkansas for Medical Sciences
- Arroyo Grande Community
- PCR Oncology
- Alta Bates Summit Medical Center-Herrick Campus
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
- Mills-Peninsula Medical Center
- East Bay Radiation Oncology Center
- Eden Hospital Medical Center
- Valley Medical Oncology Consultants-Castro Valley
- Enloe Medical Center
- Community Cancer Institute
- John Muir Medical Center-Concord Campus
- City of Hope Comprehensive Cancer Center
- Bay Area Breast Surgeons Inc
- Kaiser Permanente-Fremont
- Valley Medical Oncology Consultants-Fremont
- Washington Hospital
- California Cancer Associates for Research and Excellence (cCare)
- Saint Jude Medical Center
- Glendale Memorial Hospital and Health Center
- Marin Cancer Care Inc
- Marin General Hospital
- Saint Rose Hospital
- Scripps Green Hospital
- UC San Diego Moores Cancer Center
- Loma Linda University Medical Center
- Long Beach Memorial Medical Center-Todd Cancer Institute
- USC / Norris Comprehensive Cancer Center
- UCLA / Jonsson Comprehensive Cancer Center
- Contra Costa Regional Medical Center
- Fremont - Rideout Cancer Center
- Providence Holy Cross Medical Center
- Memorial Medical Center
- Community Hospital of Monterey Peninsula
- Palo Alto Medical Foundation-Camino Division
- Northridge Hospital Medical Center
- Sutter Cancer Research Consortium
- Highland General Hospital
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Tumor Institute
- Hematology and Oncology Associates-Oakland
- Tom K Lee Inc
- Kaiser Permanente-Oakland
- Saint Joseph Hospital - Orange
- UC Irvine Health/Chao Family Comprehensive Cancer Center
- Desert Regional Medical Center
- Stanford Cancer Institute Palo Alto
- Valley Care Health System - Pleasanton
- Valley Medical Oncology Consultants
- Pomona Valley Hospital Medical Center
- Mercy Regional Cancer Center
- Kaiser Permanente-Redwood City
- Kaiser Permanente-Richmond
- Kaiser Permanente-Roseville
- Sutter Roseville Medical Center
- Sutter Medical Center Sacramento
- University of California Davis Comprehensive Cancer Center
- Mercy General Hospital
- Kaiser Permanente-South Sacramento
- Kaiser Permanente - Sacramento
- Salinas Valley Memorial
- UC San Diego Medical Center - Hillcrest
- Kaiser Permanente-San Diego Mission
- Sharp Memorial Hospital
- Naval Medical Center -San Diego
- San Diego VA Medical Center
- Zuckerberg San Francisco General Hospital
- California Pacific Medical Center-Pacific Campus
- Kaiser Permanente-San Francisco
- Kaiser Permanente-Santa Teresa-San Jose
- Kaiser Permanente San Leandro
- Doctors Medical Center- JC Robinson Regional Cancer Center
- Kaiser Permanente-San Rafael
- Breastlink Medical Group Inc
- Cancer Center of Santa Barbara
- Ridley-Tree Cancer Center
- Sansum Clinic Inc
- Ray, Margaret, Savage. M.D. (UIA Investigator)
- Kaiser Permanente Medical Center - Santa Clara
- Kaiser Permanente-Santa Rosa
- Providence Santa Rosa Memorial Hospital
- Ridley-Tree Cancer Center-Solvang
- Kaiser Permanente-South San Francisco
- Kaiser Permanente-Stockton
- Olive View-University of California Los Angeles Medical Center
- Torrance Memorial Medical Center
- Emanuel Medical Center
- Northbay Cancer Center
- Kaiser Permanente Medical Center-Vacaville
- Kaiser Permanente-Vallejo
- Sutter Solano Medical Center/Cancer Center
- Kaiser Permanente-Walnut Creek
- John Muir Medical Center-Walnut Creek
- Presbyterian Intercommunity Hospital
- The Medical Center of Aurora
- Rocky Mountain Regional VA Medical Center
- UCHealth University of Colorado Hospital
- Boulder Community Hospital
- Penrose-Saint Francis Healthcare
- UCHealth Memorial Hospital Central
- Kaiser Permanente-Franklin
- Porter Adventist Hospital
- University of Colorado
- Presbyterian - Saint Lukes Medical Center - Health One
- SCL Health Saint Joseph Hospital
- Rose Medical Center
- Western States Cancer Research NCORP
- Shaw Cancer Center
- Swedish Medical Center
- Poudre Valley Hospital
- Saint Mary's Hospital and Regional Medical Center
- North Colorado Medical Center
- Kaiser Permanente-Rock Creek
- Saint Anthony Hospital
- Sky Ridge Medical Center
- Longmont United Hospital
- McKee Medical Center
- Montrose Memorial Hospital
- Saint Mary Corwin Medical Center
- North Suburban Medical Center
- SCL Health Lutheran Medical Center
- Hartford HealthCare - Saint Vincent's Medical Center
- Bridgeport Hospital
- Danbury Hospital
- University of Connecticut
- Greenwich Hospital
- Hartford Hospital
- Smilow Cancer Hospital Care Center at Saint Francis
- Manchester Memorial Hospital
- Middlesex Hospital
- The Hospital of Central Connecticut
- Yale-New Haven Hospital Saint Raphael Campus
- Yale University
- Eastern Connecticut Hematology and Oncology Associates
- Stamford Hospital/Bennett Cancer Center
- Smilow Cancer Hospital-Torrington Care Center
- Harold Leever Regional Cancer Center
- Bayhealth Hospital Kent Campus
- Beebe Medical Center
- Christiana Care Health System-Christiana Hospital
- MedStar Georgetown University Hospital
- MedStar Washington Hospital Center
- Sibley Memorial Hospital
- George Washington University Medical Center
- Lynn Regional Cancer Center - West
- Boca Raton Comprehensive Cancer Center
- Boca Raton Regional Hospital
- Halifax Health Medical Center-Centers for Oncology
- Broward Health North
- Holy Cross Hospital
- Broward Health Medical Center
- University of Florida Health Science Center - Gainesville
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
- Saint Vincent's Medical Center
- Baptist MD Anderson Cancer Center
- Mayo Clinic in Florida
- Jupiter Medical Center
- Lakeland Regional Health Hollis Cancer Center
- The Watson Clinic
- Cancer Centers of Central Florida PA
- Mount Sinai Medical Center
- University of Miami Miller School of Medicine-Sylvester Cancer Center
- Miami Cancer Institute
- 21st Century Oncology-Orange Park
- AdventHealth Orlando
- Orlando Health Cancer Institute
- Sacred Heart Hospital
- Florida Cancer Specialists - Sarasota Downtown
- Martin Medical Center
- Robert and Carol Weissman Cancer Center at Martin Health
- Martin Hospital South
- Space Coast Cancer Centers-Titusville
- Cleveland Clinic-Weston
- Phoebe Putney Memorial Hospital
- University Cancer and Blood Center LLC
- Grady Health System
- Piedmont Hospital
- Emory University Hospital/Winship Cancer Institute
- Atlanta Regional CCOP
- Emory Saint Joseph's Hospital
- Northside Hospital
- Augusta Oncology Associates PC-D'Antignac
- Augusta University Medical Center
- WellStar Cobb Hospital
- John B Amos Cancer Center
- Dekalb Medical Center
- Northeast Georgia Medical Center-Gainesville
- Northside Hospital - Gwinnett
- Medical Center of Central Georgia
- Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Harbin Clinic Medical Oncology and Clinical Research
- Memorial Health University Medical Center
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
- South Georgia Medical Center/Pearlman Cancer Center
- Pali Momi Medical Center
- Hawaii Cancer Care Inc - Waterfront Plaza
- Queen's Medical Center
- Straub Clinic and Hospital
- University of Hawaii Cancer Center
- Queen's Cancer Center - Kuakini
- The Cancer Center of Hawaii-Liliha
- Kapiolani Medical Center for Women and Children
- Tripler Army Medical Center
- Maui Memorial Medical Center
- Pacific Cancer Institute of Maui
- Saint Alphonsus Cancer Care Center-Boise
- Saint Luke's Cancer Institute - Boise
- Portneuf Medical Center
- Kootenai Clinic Cancer Services - Post Falls
- Saint Anthony's Health
- Northwest Community Hospital
- Rush - Copley Medical Center
- Saint Joseph Medical Center
- Illinois CancerCare-Bloomington
- Graham Hospital Association
- Illinois CancerCare-Canton
- Illinois CancerCare-Carthage
- Memorial Hospital
- Mount Sinai Hospital Medical Center
- Hematology and Oncology Associates
- Northwestern University
- John H Stroger Jr Hospital of Cook County
- Rush University Medical Center
- University of Illinois
- Mercy Hospital and Medical Center
- Swedish Covenant Hospital
- Presence Resurrection Medical Center
- University of Chicago Comprehensive Cancer Center
- Weiss Memorial Hospital
- Advocate Illinois Masonic Medical Center
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
- Decatur Memorial Hospital
- Heartland Cancer Research NCORP
- Ascension Alexian Brothers - Elk Grove Village
- Elmhurst Memorial Hospital
- Eureka Hospital
- Illinois CancerCare-Eureka
- NorthShore University HealthSystem-Evanston Hospital
- Saint Francis Hospital
- Galesburg Cottage Hospital
- Illinois CancerCare-Cottage
- Illinois CancerCare-Galesburg
- LaGrange Oncology Associates
- Northwestern Medicine Cancer Center Delnor
- Ingalls Memorial Hospital
- Illinois CancerCare-Havana
- Mason District Hospital
- Hinsdale Hematology Oncology Associates Incorporated
- Hopedale Medical Complex - Hospital
- Midwest Center for Hematology Oncology
- Duly Health and Care Joliet
- Presence Saint Mary's Hospital
- Illinois CancerCare-Kewanee Clinic
- Kewanee Hospital
- AMITA Health Adventist Medical Center
- AMG Libertyville - Oncology
- Illinois CancerCare-Macomb
- Mcdonough District Hospital
- Loyola University Medical Center
- Garneau, Stewart C MD (UIA Investigator)
- Porubcin, Michael MD (UIA Investigator)
- Sharis, Christine M MD (UIA Investigator)
- Stoffel, Thomas J MD (UIA Investigator)
- Trinity Medical Center
- Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
- Holy Family Medical Center
- Illinois CancerCare-Monmouth
- Good Samaritan Regional Health Center
- Edward Hospital/Cancer Center
- Illinois Cancer Specialists-Niles
- Bromenn Regional Medical Center
- Carle Cancer Institute Normal
- Illinois CancerCare-Community Cancer Center
- Mid-Illinois Hematology Oncology Associates Limited
- Advocate Christ Medical Center
- Franciscan St. James Health-Olympia Fields Campus
- Illinois CancerCare-Ottawa Clinic
- Ottawa Regional Hospital and Healthcare Center
- Advocate Lutheran General Hospital
- Illinois CancerCare-Pekin
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
- Pekin Hospital
- Proctor Hospital
- Illinois CancerCare-Peoria
- Methodist Medical Center of Illinois
- OSF Saint Francis Medical Center
- Illinois CancerCare-Peru
- Illinois Valley Hospital
- Illinois CancerCare-Princeton
- Perry Memorial Hospital
- West Suburban Medical Center
- Swedish American Hospital
- OSF Saint Anthony Medical Center
- Edward H Kaplan MD and Associates
- Hematology Oncology Associates of Illinois - Skokie
- Midwest Cancer Research Group Incorporated
- Illinois CancerCare-Spring Valley
- Saint Margaret's Hospital
- Memorial Medical Center
- Carle Cancer Center
- Northwestern Medicine Central DuPage Hospital
- Ascension Saint Vincent Anderson
- Franciscan Saint Francis Health-Beech Grove
- IU Health Bloomington
- Elkhart Clinic
- Elkhart General Hospital
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
- Goshen Center for Cancer Care
- Indiana University/Melvin and Bren Simon Cancer Center
- Sidney and Lois Eskenazi Hospital
- Community Cancer Center East
- Franciscan Health Indianapolis
- Community Cancer Center North
- Ascension Saint Vincent Indianapolis Hospital
- Community Howard Regional Health
- IU Health La Porte Hospital
- IU Health Arnett Cancer Care
- Horizon Oncology Research LLC
- Premier Oncology Hematology Associates
- Franciscan Saint Anthony Health-Michigan City
- Saint Joseph Regional Medical Center-Mishawaka
- IU Health Ball Memorial Hospital
- The Community Hospital
- Reid Health
- Memorial Hospital of South Bend
- Michiana Hematology Oncology PC-South Bend
- South Bend Clinic
- Northern Indiana Cancer Research Consortium
- McFarland Clinic - Ames
- Constantinou, Costas L MD (UIA Investigator)
- University of Iowa Healthcare Cancer Services Quad Cities
- Physicians' Clinic of Iowa PC
- Saint Luke's Hospital
- Mercy Hospital
- Oncology Associates at Mercy Medical Center
- Medical Oncology and Hematology Associates-West Des Moines
- Heartland Oncology and Hematology LLP
- Genesis Medical Center - East Campus
- Genesis Cancer Care Institute
- Mercy Capitol
- Iowa Methodist Medical Center
- Iowa-Wide Oncology Research Coalition NCORP
- Medical Oncology and Hematology Associates-Des Moines
- Mercy Medical Center - Des Moines
- Mission Cancer and Blood - Laurel
- Iowa Lutheran Hospital
- Finley Hospital
- Medical Associates Clinic PC
- Mercy Medical Center - North Iowa
- Ottumwa Regional Health Center
- Siouxland Regional Cancer Center
- Mercy Medical Center-Sioux City
- Saint Luke's Regional Medical Center
- Cedar Valley Medical Specialists
- MercyOne Waterloo Cancer Center
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas - El Dorado
- Cancer Center of Kansas-Independence
- Providence Medical Center
- University of Kansas Cancer Center
- Cancer Center of Kansas-Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas-Liberal
- Cancer Center of Kansas - Newton
- Olathe Cancer Center
- Olathe Health Cancer Center
- Menorah Medical Center
- Radiation Oncology Practice Corporation Southwest
- Saint Luke's South Hospital
- Cancer Center of Kansas - Parsons
- Kansas City NCI Community Oncology Research Program
- Cancer Center of Kansas - Pratt
- Cancer Center of Kansas - Salina
- Salina Regional Health Center
- Advent Health - Shawnee Mission Medical Center
- Cotton O'Neil Cancer Center / Stormont Vail Health
- University of Kansas Health System Saint Francis Campus
- Cancer Center of Kansas - Wellington
- Associates In Womens Health
- Cancer Center of Kansas-Wichita Medical Arts Tower
- Ascension Via Christi Hospitals Wichita
- Cancer Center of Kansas - Wichita
- Wichita NCI Community Oncology Research Program
- Cancer Center of Kansas - Winfield
- King's Daughter's Medical Center
- Our Lady Bellefonte Hospital
- Baptist Health Lexington
- University of Kentucky/Markey Cancer Center
- The James Graham Brown Cancer Center at University of Louisville
- Baptist Health Louisville
- Baptist Health Madisonville/Merle Mahr Cancer Center
- Owensboro Health Mitchell Memorial Cancer Center
- Christus Saint Frances Cabrini Hospital
- Baton Rouge General Medical Center
- Mary Bird Perkins Cancer Center
- Ochsner Health Center-Summa
- Ochsner Health Center-Covington
- Metairie Oncologists
- Ochsner LSU Health Monroe Medical Center
- Louisiana State University Health Science Center
- Tulane University Health Sciences Center
- University Medical Center New Orleans
- Ochsner Medical Center Jefferson
- Overton Brooks Veteran's Administration Medical Center
- LSU Health Sciences Center at Shreveport
- CHRISTUS Highland Medical Center
- Highland Clinic
- Harold Alfond Center for Cancer Care
- Eastern Maine Medical Center
- Central Maine Medical Center
- Saint Mary's Regional Medical Center
- Mercy Hospital
- Maine Center for Cancer Medicine-Scarborough
- Maine Medical Center- Scarborough Campus
- Maine General Medical Center-Thayer
- York Hospital
- Anne Arundel Medical Center
- Mercy Medical Center
- Greater Baltimore Medical Center
- Sinai Hospital of Baltimore
- MedStar Union Memorial Hospital
- Saint Agnes Hospital
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
- MedStar Good Samaritan Hospital
- Johns Hopkins University/Sidney Kimmel Cancer Center
- Suburban Hospital
- Walter Reed National Military Medical Center
- UPMC Western Maryland
- University of Maryland Shore Medical Center at Easton
- Christiana Care - Union Hospital
- Frederick Memorial Hospital
- Associates in Oncology Hematology PC -Kensington
- Maryland Oncology Hematology PA-Aquilino Cancer Center
- TidalHealth Peninsula Regional
- Holy Cross Hospital
- UM Saint Joseph Medical Center
- Sturdy Memorial Hospital
- Tufts Medical Center
- Massachusetts General Hospital Cancer Center
- Brigham and Women's Hospital
- Boston Medical Center
- Beth Israel Deaconess Medical Center
- Dana-Farber Cancer Institute
- Steward Saint Elizabeth's Medical Center
- Lahey Hospital and Medical Center
- Commonwealth Hematology Oncology PC-Concord
- Mass General/North Shore Cancer Center
- Dana Farber Community Cancer Care-Dorchester
- Saint Anne's Hospital
- Simonds-Sinon Regional Cancer Center
- MetroWest Medical Center-Framingham Union Hospital
- Addison Gilbert Hospital
- Dana Farber Community Cancer Care-Haverhill
- Cape Cod Hospital
- HealthAlliance Hospital - Leominster
- Saints Memorial Medical Center
- Lowell General Hospital
- Dana Farber-Merrimack Valley
- Holy Family Hospital
- Norwood Hospital
- Berkshire Medical Center - Cancer Center
- Dana Farber Community Cancer Care-Quincy
- South Shore Hospital
- Baystate Medical Center
- Dana Farber Community Cancer Care-Stoneham
- Morton Hospital and Medical Center
- Dana Farber Community Cancer Care-Weymouth
- Commonwealth Hematology Oncology PC-Worcester
- Reliant Medical Group Inc
- UMass Memorial Medical Center - University Campus
- Bixby Medical Center
- Hickman Cancer Center
- Michigan Cancer Research Consortium NCORP
- Saint Joseph Mercy Hospital
- University of Michigan Comprehensive Cancer Center
- Bronson Battle Creek
- McLaren Cancer Institute-Bay City
- Spectrum Health Big Rapids Hospital
- Beaumont Hospital - Dearborn
- Wayne State University/Karmanos Cancer Institute
- Henry Ford Hospital
- Ascension Saint John Hospital
- Michigan State University Clinical Center
- Green Bay Oncology - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Genesys Regional Medical Center-West Flint Campus
- McLaren Cancer Institute-Flint
- Cancer Research Consortium of West Michigan NCORP
- Spectrum Health at Butterworth Campus
- Trinity Health Grand Rapids Hospital
- Holland Community Hospital
- Green Bay Oncology - Iron Mountain
- Allegiance Health
- Bronson Methodist Hospital
- West Michigan Cancer Center
- Borgess Medical Center
- Karmanos Cancer Institute at McLaren Greater Lansing
- Sparrow Hospital
- Lapeer Regional Hospital
- Trinity Health Saint Mary Mercy Livonia Hospital
- UP Health System Marquette
- MyMichigan Medical Center Midland
- Mercy Memorial Hospital
- Toledo Clinic Cancer Centers-Monroe
- McLaren Cancer Institute-Macomb
- Mercy Health Partners-Hackley Campus
- Trinity Health Muskegon Hospital
- McLaren Cancer Institute-Northern Michigan
- Saint Joseph Mercy Oakland
- Lake Huron Medical Center
- Crittenton Hospital
- William Beaumont Hospital-Royal Oak
- Ascension Saint Mary's Hospital
- Lakeland Medical Center Saint Joseph
- Marie Yeager Cancer Center
- Oncology Care Associates PLLC
- Ascension Providence Hospitals - Southfield
- Munson Medical Center
- Saint John Macomb-Oakland Hospital
- University of Michigan Health - West
- Medini, Eitan MD (UIA Investigator)
- Sanford Joe Lueken Cancer Center
- Fairview Ridges Hospital
- Mercy Hospital
- Essentia Health Cancer Center
- Essentia Health Saint Mary's Medical Center
- Miller-Dwan Hospital
- Saint Luke's Hospital of Duluth
- Fairview Southdale Hospital
- Etzell, Paul S MD (UIA Investigator)
- Lake Region Healthcare Corporation-Cancer Care
- Swenson, Wade II, MD (UIA Investigator)
- Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- Mayo Clinic Health Systems-Mankato
- Minnesota Oncology Hematology PA-Maplewood
- Saint John's Hospital - Healtheast
- Abbott-Northwestern Hospital
- Virginia Piper Cancer Institute
- Hennepin County Medical Center
- University of Minnesota/Masonic Cancer Center
- Chippewa County - Montevideo Hospital
- North Memorial Medical Health Center
- Mayo Clinic in Rochester
- Coborn Cancer Center at Saint Cloud Hospital
- Saint Cloud Hospital
- Metro Minnesota Community Oncology Research Consortium
- Park Nicollet Clinic - Saint Louis Park
- Regions Hospital
- Saint Joseph's Hospital - Healtheast
- United Hospital
- Saint Francis Regional Medical Center
- Ridgeview Medical Center
- Rice Memorial Hospital
- Minnesota Oncology Hematology PA-Woodbury
- Woodwinds Health Campus
- Hattiesburg Clinic - Hematology/Oncology Clinic
- Hematology and Oncology Clinic
- Jackson Oncology Associates PLLC
- University of Mississippi Medical Center
- Keesler Medical Center
- Singing River Hospital
- Southeast Missouri Hospital
- Saint Francis Medical Center
- Saint Luke's Hospital
- Missouri Cancer Associates
- Veterans Administration
- MU Health - University Hospital/Ellis Fischel Cancer Center
- Centerpoint Medical Center LLC
- Capital Region Medical Center
- Capital Region Southwest Campus
- Freeman Health System
- Mercy Hospital Joplin
- Truman Medical Centers
- Saint Luke's Hospital of Kansas City
- Radiation Oncology Practice Corporation South
- Saint Joseph Health Center
- North Kansas City Hospital
- Heartland Hematology and Oncology Associates Incorporated
- Research Medical Center
- Radiation Oncology Practice Corporation - North
- Saint Luke's East - Lee's Summit
- Liberty Radiation Oncology Center
- Heartland Regional Medical Center
- SSM Health Saint Louis University Hospital
- Saint Louis Cancer and Breast Institute-South City
- Washington University School of Medicine
- Mercy Hospital South
- Missouri Baptist Medical Center
- Siteman Cancer Center at Christian Hospital
- Center for Cancer Care and Research
- Mercy Hospital Saint Louis
- Saint Louis-Cape Girardeau CCOP
- Cancer Research for the Ozarks NCORP
- Mercy Hospital Springfield
- CoxHealth South Hospital
- Billings Clinic Cancer Center
- Northern Rockies Radiation Oncology Center
- Saint Vincent Healthcare
- Montana Cancer Consortium NCORP
- Saint Vincent Frontier Cancer Center
- Deaconess Medical Center
- Bozeman Deaconess Hospital
- Saint James Community Hospital and Cancer Treatment Center
- Benefis Healthcare- Sletten Cancer Institute
- Berdeaux, Donald MD (UIA Investigator)
- Great Falls Clinic
- Northern Montana Hospital
- Saint Peter's Community Hospital
- Glacier Oncology PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Montana Cancer Specialists
- Saint Patrick Hospital - Community Hospital
- Community Medical Hospital
- Guardian Oncology and Center for Wellness
- CHI Health Saint Francis
- CHI Health Good Samaritan
- Nebraska Cancer Research Center
- Cancer Alliance of Nebraska
- Missouri Valley Cancer Consortium
- Nebraska Methodist Hospital
- Alegent Health Immanuel Medical Center
- Alegent Health Bergan Mercy Medical Center
- Alegent Health Lakeside Hospital
- Creighton University Medical Center
- University of Nebraska Medical Center
- Midlands Community Hospital
- Carson-Tahoe Specialty Medical Center
- University Medical Center of Southern Nevada
- Nevada Cancer Research Foundation NCORP
- Renown Regional Medical Center
- Saint Mary's Regional Medical Center
- New Hampshire Oncology Hematology PA-Concord
- Exeter Hospital
- Cheshire Medical Center-Dartmouth-Hitchcock Keene
- LRGHealthcare-Lakes Region General Hospital
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
- Elliot Hospital
- Solinsky Center for Cancer Care
- Foundation Medical Partners
- Saint Joseph Hospital
- Portsmouth Regional Hospital
- Ocean University Medical Center
- Cooper Hospital University Medical Center
- John F Kennedy Medical Center
- Englewood Hospital and Medical Center
- Hunterdon Medical Center
- CentraState Medical Center
- Hackensack University Medical Center
- The Cancer Institute of New Jersey Hamilton
- Saint Barnabas Medical Center
- Monmouth Medical Center
- Mountainside Hospital
- Morristown Medical Center
- Virtua Memorial
- Jersey Shore Medical Center
- Saint Peter's University Hospital
- Rutgers Cancer Institute of New Jersey
- Rutgers New Jersey Medical School
- Saint Michael's Medical Center
- Newark Beth Israel Medical Center
- Saint Joseph's Regional Medical Center
- Capital Health Medical Center-Hopewell
- Saint Luke's Hospital-Warren Campus
- Penn Medicine Princeton Health
- AtlantiCare Regional Medical Center -Main Campus
- Riverview Medical Center/Booker Cancer Center
- Valley Hospital
- Shore Memorial Hospital
- Robert Wood Johnson University Hospital Somerset
- Sparta Cancer Treatment Center
- Overlook Hospital
- Community Medical Center
- Inspira Medical Center Vineland
- Virtua Voorhees
- Lovelace Medical Center-Downtown
- University of New Mexico Cancer Center
- Hematology Oncology Associates
- Presbyterian Kaseman Hospital
- Memorial Medical Center - Las Cruces
- San Juan Regional Medical Center
- Christus Saint Vincent Regional Cancer Center
- New York Oncology Hematology PC - Albany
- New York Oncology Hematology PC - Albany Medical Center
- New York Oncology Hematology PC - Amsterdam
- Lincoln Medical and Mental Health Center
- Bronx-Lebanon Hospital Center
- Montefiore Medical Center-Weiler Hospital
- Montefiore Medical Center-Wakefield Campus
- Montefiore Medical Center - Moses Campus
- Coney Island Hospital
- Roswell Park Cancer Institute
- New York Oncology Hematology PC - Clifton Park
- Finger Lakes Hematology and Oncology
- Mary Imogene Bassett Hospital
- Hematology Oncology Associates of Central New York-East Syracuse
- Adirondack Cancer Center
- Glens Falls Hospital
- Catskill Regional Medical Center
- New York Oncology Hematology PC-Hudson
- Queens Hospital Center
- Benedictine Hospital
- Northwell Health NCORP
- Northwell Health/Center for Advanced Medicine
- North Shore University Hospital
- Garnet Health Medical Center
- NYU Winthrop Hospital
- Long Island Jewish Medical Center
- Mount Sinai Union Square
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
- Mount Sinai West
- Mount Sinai Hospital
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
- Ralph Lauren Center for Cancer Care and Prevention
- Memorial Sloan Kettering Cancer Center
- NYP/Weill Cornell Medical Center
- Nyack Hospital
- Champlain Valley Physicians Hospital Medical Center
- Hudson Valley Hematology Oncology Associates
- MidHudson Regional Hospital of Westchester Medical Center
- The Dyson Center for Cancer Care
- Vassar Brothers Medical Center
- Highland Hospital
- Rochester General Hospital
- Interlakes Foundation Inc-Rochester
- University of Rochester
- Staten Island University Hospital
- Richmond University Medical Center
- Stony Brook University Medical Center
- State University of New York Upstate Medical University
- New York Oncology Hematology PC - Troy
- Faxton-Saint Luke's Healthcare
- Randolph Hospital
- Mission Hospital
- Hope Women's Cancer Centers-Asheville
- Waverly Hematology Oncology
- UNC Lineberger Comprehensive Cancer Center
- Carolinas Medical Center/Levine Cancer Institute
- Novant Health Presbyterian Medical Center
- Atrium Health Cabarrus/LCI-Concord
- Duke University Medical Center
- Moorehead Memorial Hospital
- Cape Fear Valley Health System
- CaroMont Regional Medical Center
- Wayne Memorial Hospital
- Wayne Radiation Oncology
- Cone Health Cancer Center
- East Carolina University
- AdventHealth Hendersonville
- Maria Parham Hospital
- High Point Regional Hospital
- Vidant Oncology-Kinston
- Southeastern Regional Medical Center
- Granville Medical Center
- FirstHealth of the Carolinas-Moore Regional Hospital
- UNC Rex Healthcare
- Duke Raleigh Hospital
- Annie Penn Memorial Hospital
- Person Memorial Hospital
- Rutherford Hospital
- Iredell Memorial Hospital
- Marion L Shepard Cancer Center at Vidant Beaufort Hospital
- Novant Health New Hanover Regional Medical Center
- Wilson Medical Center
- Novant Health Forsyth Medical Center
- Southeast Clinical Oncology Research Consortium NCORP
- Wake Forest University Health Sciences
- Mid Dakota Clinic
- Saint Alexius Medical Center
- Sanford Bismarck Medical Center
- Sanford Broadway Medical Center
- Sanford Clinic North-Fargo
- Altru Cancer Center
- Trinity Cancer Care Center
- Summa Health System - Akron Campus
- Cleveland Clinic Akron General
- Summa Health System - Barberton Campus
- Mary Rutan Hospital
- Toledo Clinic Cancer Centers-Bowling Green
- Community Hospital and Wellness Centers
- Cleveland Clinic Mercy Hospital
- Aultman Health Foundation
- Adena Regional Medical Center
- The Christ Hospital
- University of Cincinnati Cancer Center-UC Medical Center
- Good Samaritan Hospital - Cincinnati
- Oncology Hematology Care Inc-Blue Ash
- Case Western Reserve University
- MetroHealth Medical Center
- Cleveland Clinic Cancer Center/Fairview Hospital
- Cleveland Clinic Foundation
- North Coast Cancer Care-Clyde
- Ohio State University Comprehensive Cancer Center
- Riverside Methodist Hospital
- Columbus NCI Community Oncology Research Program
- Grant Medical Center
- Mount Carmel Health Center West
- Doctors Hospital
- Grandview Hospital
- Good Samaritan Hospital - Dayton
- Miami Valley Hospital
- Miami Valley Hospital North
- Dayton Veterans Affairs Medical Center
- Dayton NCI Community Oncology Research Program
- Grady Memorial Hospital
- Hematology Oncology Center Incorporated
- Blanchard Valley Hospital
- Atrium Medical Center-Middletown Regional Hospital
- Fremont Memorial Hospital
- Wayne Hospital
- Cleveland Clinic Cancer Center Independence
- Cole, Sharon, K. M.D. (UIA Investigator)
- Kettering Medical Center
- Fairfield Medical Center
- Saint Rita's Medical Center
- Lima Memorial Hospital
- OhioHealth Mansfield Hospital
- Marietta Memorial Hospital
- Saint Luke's Hospital
- Toledo Clinic Cancer Centers-Maumee
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
- Hillcrest Hospital Cancer Center
- Licking Memorial Hospital
- Fisher-Titus Medical Center
- Saint Charles Hospital
- Toledo Clinic Cancer Centers-Oregon
- UH Seidman Cancer Center at Salem Regional Medical Center
- Firelands Regional Medical Center
- North Coast Cancer Care
- Springfield Regional Medical Center
- ProMedica Flower Hospital
- Mercy Hospital of Tiffin
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
- Saint Vincent Mercy Medical Center
- University of Toledo
- Toledo Community Hospital Oncology Program CCOP
- Mercy Health - Saint Anne Hospital
- Stark, Michael, Edward. M.D. (UIA Investigator)
- Toledo Clinic Cancer Centers-Toledo
- Upper Valley Medical Center
- Saint Joseph Warren Hospital
- Fulton County Health Center
- Saint Ann's Hospital
- Clinton Memorial Hospital
- Cancer Treatment Center
- Cleveland Clinic Wooster Family Health and Surgery Center
- Wright-Patterson Medical Center
- Greene Memorial Hospital
- Tod Children's Hospital - Forum Health
- Genesis Healthcare System Cancer Care Center
- Cancer Centers of Southwest Oklahoma Research
- University of Oklahoma Health Sciences Center
- Cancer Care Associates
- Mercy Hospital Oklahoma City
- Saint John Medical Center
- Natalie Warren Bryant Cancer Center at Saint Francis
- Bend Memorial Clinic
- Saint Charles Health System
- Bay Area Hospital
- Three Rivers Community Hospital
- Legacy Mount Hood Medical Center
- Sky Lakes Medical Center - Cancer Treatment Center
- Asante Health System
- Providence Medford Medical Center
- Rogue Valley Medical Center
- Providence Milwaukie Hospital
- Legacy Good Samaritan Hospital and Medical Center
- Providence Portland Medical Center
- Adventist Medical Center
- Providence Saint Vincent Medical Center
- Compass Oncology Rose Quarter
- Kaiser Permanente Northwest
- Legacy Emanuel Hospital and Health Center
- Oregon Health and Science University
- Salem Hospital
- Legacy Meridian Park Hospital
- Jefferson Abington Hospital
- Sacred Heart Hospital
- Lehigh Valley Hospital-Cedar Crest
- Saint Luke's University Hospital-Bethlehem Campus
- Bryn Mawr Hospital
- Geisinger Medical Center
- Mercy Fitzgerald Hospital
- Doylestown Hospital
- Delaware County Memorial Hospital
- Oncology Hematology Associates of Northern Pennsylvania
- Pocono Medical Center
- Easton Hospital
- Ephrata Cancer Center
- UPMC Hillman Cancer Center Erie
- Saint Vincent Hospital
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
- Geisinger Medical Center-Cancer Center Hazleton
- Penn State Milton S Hershey Medical Center
- Conemaugh Memorial Medical Center
- Lancaster General Hospital
- Saint Mary Medical and Regional Cancer Center
- Lewistown Hospital
- Holy Redeemer Hospital and Medical Center
- Riddle Memorial Hospital
- Paoli Memorial Hospital
- Drexel University School of Medicine
- University of Pennsylvania/Abramson Cancer Center
- Pennsylvania Hospital
- Thomas Jefferson University Hospital
- Fox Chase Cancer Center
- Jefferson Torresdale Hospital
- Chestnut Hill Health System
- Einstein Medical Center Philadelphia
- Phoenixville Hospital
- Allegheny General Hospital
- UPMC-Magee Womens Hospital
- West Penn Hospital
- University of Pittsburgh Cancer Institute (UPCI)
- Pottstown Hospital
- Penn State Health Saint Joseph Medical Center
- Guthrie Medical Group PC-Robert Packer Hospital
- Mercy Hospital
- Hematology and Oncology Associates of North East Pennsylvania
- Scranton Hematology Oncology
- Grand View Hospital
- Geisinger Medical Group
- Mount Nittany Medical Center
- Associates In Hematology Oncology PC-Upland
- Chester County Hospital
- Jennersville Regional Hospital
- Reading Hospital
- Geisinger Wyoming Valley/Henry Cancer Center
- UPMC Susquehanna
- Lankenau Medical Center
- Main Line Health NCORP
- WellSpan Health-York Hospital
- Hematology and Oncology Associates of Rhode Island Inc
- Memorial Hospital of Rhode Island
- Rhode Island Hospital
- Women and Infants Hospital
- Miriam Hospital
- Roger Williams Medical Center
- Kent Hospital
- AnMed Health Hospital
- Beaufort Memorial Hospital
- Roper Hospital
- Medical University of South Carolina
- South Carolina Oncology Associates PA
- McLeod Regional Medical Center
- Tidelands Georgetown Memorial Hospital
- Saint Francis Hospital
- Prisma Health Cancer Institute - Eastside
- Spartanburg Medical Center
- Avera Cancer Institute-Aberdeen
- Sanford Cancer Center Oncology Clinic
- Avera Cancer Institute
- Medical X-Ray Center
- Avera McKennan Hospital and University Health Center
- Sanford USD Medical Center - Sioux Falls
- Wellmont Medical Associates Oncology and Hematology-Bristol
- Erlanger Medical Center
- Cookeville Regional Medical Center
- Vanderbilt-Ingram Cancer Center Cool Springs
- Jones Clinic
- Jackson-Madison County General Hospital
- The Jackson Clinic PA
- Wellmont Holston Valley Hospital and Medical Center
- Tennessee Cancer Specialists-Dowell Springs
- Thompson Cancer Survival Center
- East Tennessee Baptist Hospital-Mercy Health Partners
- University of Tennessee - Knoxville
- University of Tennessee Health Science Center
- Nashville Breast Center
- Nashville Oncology Associates PC
- Tennessee Oncology PLLC- Centennial Medical Center
- Vanderbilt Breast Center at One Hundred Oaks
- Saint Thomas Hospital
- Meharry Medical College
- Vanderbilt University/Ingram Cancer Center
- Saint Thomas Midtown Hospital
- Saint Mary's North Cancer Center
- The Don and Sybil Harrington Cancer Center
- Dell Seton Medical Center at The University of Texas
- Texas Oncology-Austin Midtown
- Texas Oncology - Central Austin Cancer Center
- Texas Oncology - South Austin Cancer Center
- Texas Oncology-Austin North
- Texas Oncology Seton Northwest
- Saint Joseph Regional Cancer Center
- The Center for Cancer and Blood Disorders-Burleson
- Texas Oncology-Cedar Park
- The Center for Cancer and Blood Disorders-Cleburne
- Medical City Dallas Hospital
- Parkland Memorial Hospital
- Clements University Hospital
- UT Southwestern/Simmons Cancer Center-Dallas
- Dallas Oncology Consultants PA
- The Center for Integrative Cancer Medicine
- Brooke Army Medical Center
- The Center for Cancer and Blood Disorders-Fort Worth
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
- Ben Taub General Hospital
- Houston Methodist Hospital
- M D Anderson Cancer Center
- Wilford Hall Medical Center
- Doctor's Hospital of Laredo
- Covenant Medical Center-Lakeside
- Texas Tech University Health Sciences Center-Lubbock
- The Center for Cancer and Blood Disorders-Mineral Wells
- Texas Oncology-Seton Williamson
- Texas Oncology - Round Rock Cancer Center
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
- University Hospital
- University of Texas Health Science Center at San Antonio
- Texas Oncology- San Marcos
- Scott and White Memorial Hospital
- The Center for Cancer and Blood Disorders-Weatherford
- American Fork Hospital / Huntsman Intermountain Cancer Center
- Sandra L Maxwell Cancer Center
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- Intermountain Medical Center
- McKay-Dee Hospital Center
- Utah Valley Regional Medical Center
- Saint George Regional Medical Center
- Intermountain Health Care
- Utah Cancer Specialists-Salt Lake City
- LDS Hospital
- Southwestern Vermont Medical Center
- University of Vermont and State Agricultural College
- Rutland Regional Medical Center
- Mount Ascutney Hospital and Health Center
- Sentara Martha Jefferson Hospital
- University of Virginia Cancer Center
- Danville Regional Medical Center
- Inova Fairfax Hospital
- Fredericksburg Oncology Inc
- Peninsula Cancer Institute-Gloucester
- Virginia Oncology Associates-Hampton
- Centra Lynchburg Hematology-Oncology Clinic Inc
- Peninsula Cancer Institute-Newport News
- Sentara Port Warwick
- Eastern Virginia Medical School
- Southwest VA Regional Cancer Center
- Virginia Cancer Institute
- Virginia Commonwealth University/Massey Cancer Center
- Peninsula Cancer Institute-Williamsburg
- MultiCare Auburn Medical Center
- PeaceHealth Saint Joseph Medical Center
- Harrison HealthPartners Hematology and Oncology-Bremerton
- Providence Regional Cancer System-Centralia
- Saint Francis Hospital
- Kadlec Clinic Hematology and Oncology
- EvergreenHealth Medical Center
- Saint Clare Hospital
- PeaceHealth Saint John Medical Center
- Providence - Saint Peter Hospital
- Capital Medical Center
- Olympic Medical Center
- Harrison HealthPartners Hematology and Oncology-Poulsbo
- MultiCare Good Samaritan Hospital
- Valley Medical Center
- Virginia Mason Medical Center
- Minor and James Medical PLLC
- Pacific Medical Center-First Hill
- Kaiser Permanente Washington
- Swedish Medical Center-First Hill
- University of Washington Medical Center - Montlake
- Cancer Care Northwest - Spokane South
- Providence Sacred Heart Medical Center and Children's Hospital
- Providence Holy Family Hospital
- Evergreen Hematology and Oncology PS
- Rockwood Clinic
- MultiCare Allenmore Hospital
- MultiCare Tacoma General Hospital
- Northwest NCI Community Oncology Research Program
- Saint Joseph Medical Center
- Madigan Army Medical Center
- PeaceHealth Southwest Medical Center
- Compass Oncology Vancouver
- Cancer Institutes of Washington PLLC
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- United Hospital Center
- West Virginia University Charleston Division
- Edwards Comprehensive Cancer Center
- Marshall University Medical Center
- Saint Mary's Medical Center
- West Virginia University Healthcare
- Camden Clark Medical Center
- Princeton Community Hospital
- Wheeling Hospital/Schiffler Cancer Center
- Langlade Hospital and Cancer Center
- Fox Valley Surgical Associates Limited
- ThedaCare Regional Cancer Center
- Aurora Cancer Care-Southern Lakes VLCC
- Marshfield Clinic-Chippewa Center
- HSHS Sacred Heart Hospital
- Marshfield Clinic Cancer Center at Sacred Heart
- Saint Agnes Hospital/Agnesian Cancer Center
- Aurora Cancer Care-Franklin
- Aurora Cancer Care-Glendale
- Green Bay Oncology at Saint Vincent Hospital
- Saint Vincent Hospital Cancer Center Green Bay
- Green Bay Oncology Limited at Saint Mary's Hospital
- Saint Vincent Hospital Cancer Center at Saint Mary's
- Aurora BayCare Medical Center
- Mercyhealth Hospital and Cancer Center - Janesville
- UW Cancer Center Johnson Creek
- Aurora Cancer Care-Kenosha South
- Gundersen Lutheran Medical Center
- Mayo Clinic Health System-Franciscan Healthcare
- Dean Hematology and Oncology Clinic
- University of Wisconsin Carbone Cancer Center
- Holy Family Memorial Hospital
- Aurora Bay Area Medical Group-Marinette
- Bay Area Medical Center
- Marshfield Medical Center-Marshfield
- Marshfield Medical Center
- Ascension Columbia Saint Mary's Hospital Ozaukee
- Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
- Ascension Columbia Saint Mary's Hospital - Milwaukee
- Aurora Saint Luke's Medical Center
- Medical College of Wisconsin
- Aurora Sinai Medical Center
- Marshfield Clinic-Minocqua Center
- ProHealth Oconomowoc Memorial Hospital
- Saint Vincent Hospital Cancer Center at Oconto Falls
- Vince Lombardi Cancer Clinic - Oshkosh
- Ascension All Saints Hospital
- Ascension Saint Mary's Hospital
- Marshfield Medical Center-Rice Lake
- Vince Lombardi Cancer Clinic-Sheboygan
- Ascension Saint Michael's Hospital
- Green Bay Oncology - Sturgeon Bay
- Aurora Medical Center in Summit
- Vince Lombardi Cancer Clinic-Two Rivers
- ProHealth Waukesha Memorial Hospital
- Aspirus Regional Cancer Center
- Marshfield Clinic-Wausau Center
- Aurora Cancer Care-Milwaukee West
- Aurora West Allis Medical Center
- Marshfield Medical Center - Weston
- Aspirus Cancer Care - Wisconsin Rapids
- Marshfield Clinic - Wisconsin Rapids Center
- Rocky Mountain Oncology
- Welch Cancer Center
- Border Medical Oncology
- Coffs Harbour Health Campus-North Coast Cancer Institute
- Concord Repatriation General Hospital
- Lismore Base Hospital
- Lingard Private Hospital
- Royal Newcastle Hospital
- Calvary Mater Newcastle Hospital
- Royal Brisbane and Women's Hospital
- Nambour Hospital
- Royal Hobart Hospital
- Breast Unit-Mercy Private
- Epworth Hospital
- Saint John of God Hospital - Bunbury
- Sir Charles Gairdner Hospital
- Tom Baker Cancer Centre
- BCCA-Cancer Centre for the Southern Interior
- Penticton Regional Hospital
- BCCA-Fraser Valley Cancer Centre
- BCCA-Vancouver Cancer Centre
- BCCA-Vancouver Island Cancer Centre
- CancerCare Manitoba
- The Moncton Hospital
- Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Trillium Health Partners - Credit Valley Hospital
- Health Sciences North
- Thunder Bay Regional Health Science Centre
- Michael Garron Hospital
- Odette Cancer Centre- Sunnybrook Health Sciences Centre
- Saint Michael's Hospital
- Trillium Health Partners - Queensway Health Centre
- Windsor Regional Cancer Centre
- CSSS Champlain-Charles Le Moyne
- CIUSSSEMTL-Hopital Maisonneuve-Rosemont
- CHUM - Hopital Notre-Dame
- McGill University Department of Oncology
- CHUM-Hotel Dieu de Montreal
- CHUM - Centre Hospitalier de l'Universite de Montreal
- The Research Institute of the McGill University Health Centre (MUHC)
- Jewish General Hospital
- CHU de Quebec-Hopital du Saint-Sacrement (HSS)
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre
- Bon Secours Hospital
- South Infirmary Victoria Hospital
- Tallaght University Hospital
- Saint Vincent's University Hospital
- Mater Misericordiae University Hospital
- Mater Private Hospital
- Beaumont Hospital
- Saint Vincent's Private Hospital
- University College Hospital Galway
- Mid-Western Regional Hospital
- Sligo University Hospital
- University Hospital Waterford
- Cork University Hospital
- Saint James Hospital
- Letterkenny General Hospital
- Auckland City Hospital
- Waikato Hospital
- Wellington Hospital
- Instituto Nacional de Enfermedades Neoplasicas
- San Juan City Hospital
- Belfast City Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Experimental
Group 1 (Oncotype DX recurrence score =< 10)
Group 2, Arm I (experimental)
Group 2, Arm II (standard)
Group 3 (Oncotype DX recurrence score >= 26)
Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years.
Patients receive hormonal therapy as in Group 1 at the discretion of the treating physician.
Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician.
Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in group two who are assigned to receive both types of treatment.