Hospitalization Rates of Patients With Non-Small Cell Lung Cancer Treated With Gemcitabine and Either Cisplatin or Carboplatin
Lung Cancer
About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer, stage IV non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed inoperable non-small cell lung cancer Stage IIIA, IIIB, or IV Not eligible for curative radiotherapy or surgery No symptomatic brain metastases PATIENT CHARACTERISTICS: Age 18 and over Performance status Karnofsky 50-100% Life expectancy At least 12 weeks Hematopoietic WBC at least 3,000/mm^3 Absolute neutrophil count at least 2,000/mm^3 Platelet count at least 100,000/mm^3 Hemoglobin at least 10 g/dL Hepatic Bilirubin no greater than 2 times upper limit of normal (ULN) AST no greater than 2.5 times ULN Alkaline phosphatase no greater than 3 times ULN (5 times ULN if liver metastases present) Renal Creatinine no greater than ULN OR Creatinine clearance at least 60 mL/min Other Not pregnant or nursing Fertile patients must use effective contraception during and for 3 months after study completion No active infection No serious systemic disorder that would preclude study participation No grade 2 or greater peripheral neuropathy No significant neurological problems (e.g., seizures or psychiatric disorders) No other active malignancy within the past 5 years except carcinoma in situ of the cervix or adequately treated non-melanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy No prior cytotoxic chemotherapy No other concurrent chemotherapy during or for 7 days after study therapy Endocrine therapy Not specified Radiotherapy See Disease Characteristics No prior radiotherapy No concurrent radiotherapy during or for 7 days after study therapy Surgery See Disease Characteristics Other At least 12 weeks since prior investigational agents No other concurrent antitumor therapy No concurrent experimental medications
Sites / Locations
- Christie Hospital NHS Trust