Human Sperm Epigenetics in Embryonic Development. (EPI)
Male Infertility, Epigenetic Disorder
About this trial
This is an interventional diagnostic trial for Male Infertility focused on measuring assisted reproductive technology, DNA fragmentation, histone, protamine, blastocyst
Eligibility Criteria
Inclusion Criteria:
- Men with a history of infertility. Sperm concentration must be >15 millions per ml.
Exclusion Criteria:
- No vulnerable persons will be invited to participate.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
good embryo development in assisted reproduction
poor embryo development in assisted reproduction
natural conception
20 infertile men treated with assisted reproduction with normal embryo development in vitro, as demonstrated in a previous treatment with assisted reproductive technology (defined by normal fertilization rate >50% and normal blastocyst development rate >50%).
20 infertile men treated with assisted reproduction with poor embryo development in vitro, as demonstrated in a previous treatment with assisted reproductive technology (defined by normal or slightly reduced fertilization rate <50% and low or absent blastocyst development (0 or only 1 blastocyst).
20 previously infertile men, normal history, normal genital status, normal sperm count, DNA fragmentation rate <20% (as given by TUNEL) and achieving pregnancy naturally (without medical intervention).