Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain
Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Radiation Toxicity
About this trial
This is an interventional supportive care trial for Brain and Central Nervous System Tumors focused on measuring cognitive/functional effects, radiation toxicity, adult brain tumor, childhood brain tumor
Eligibility Criteria
DISEASE CHARACTERISTICS: Definitive diagnosis of brain radionecrosis by MRI and positron emission tomography scan Clinically symptomatic with signs of worsening neurologic deficits (e.g., focal deficits or intractable seizures) Condition currently managed with increasing steroid dosage PATIENT CHARACTERISTICS: No severe pulmonary disease (i.e., untreated pneumothorax, emphysema, chronic obstructive pulmonary disease, or asthma) No active congestive heart failure LVEF ≥ 35% Not pregnant Negative pregnancy test Fertile patients must use effective contraception No psychological, familial, sociological, or geographical conditions that would preclude study compliance PRIOR CONCURRENT THERAPY: See Disease Characteristics No prior or concurrent bleomycin No concurrent doxorubicin hydrochloride No concurrent disulfiram
Sites / Locations
- University of Cincinnati Medical Center