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Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer (HYPOSIB)

Primary Purpose

Early-Stage Breast Carcinoma

Status
Unknown status
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
Standard Radiation
Hypofractionation with SIB
Sponsored by
University Hospital Schleswig-Holstein
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Early-Stage Breast Carcinoma focused on measuring Breast cancer, Hypofractionation with SIB, Non-inferiority, adjuvant radiotherapy with simultaneous integrated boost

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria:

  • Histopathologically confirmed breast cancer operated by breast conserving surgery with clear margins independently of further risk factors (positive or high-risk negative lymph node status, estrogen- or progesterone receptor status, Her-2/neu status uPA/PAI-1 criteria) and postoperative systemic therapy (chemotherapy, endocrine, antibody or bisphosphonate therapy were permitted when indicated)
  • Indication to adjuvant radiotherapy including boost radiotherapy
  • Clearly identified primary tumor region preferably by radiopaque clips
  • Primary wound healing after breast conserving therapy without signs of infection
  • Age ≥ 18 years
  • ECOG ≤ 2 Performance Status
  • Written informed consent
  • Compliance regarding treatment appointments and toxicity
  • Linguistic and cognitive ability to understand the questionnaires

Exclusion Criteria:

  • Patients operated by mastectomy
  • No indication for boost radiation (e.g. status after IORT)
  • double sided breast cancer
  • Resection margins positive for disease or insufficient identification of the boost volume
  • Indication for radiotherapy of the regional lymph nodes
  • History of prior breast or thoracic radiotherapy
  • Extended postoperative seroma at the beginning of radiotherapy
  • Previously administered radiotherapy not allowing the required dose
  • Pregnant or lactating patients and woman of child bearing potential, who lacked effective contraception
  • treatment history of other cancer or participation in another clinical trial testing radiotherapy or drugs within 4 weeks of the start of treatment.
  • Patients with serious, uncontrolled, physical or cerebrovascular disorders(e.g. myocardial infarction within the last 12 months) or neurologiy or psychiatric disorders thought to adversly affect treatment compliance

Sites / Locations

  • Gesundheitszentrum St.Marien Gmbh und Klinik für Strahlentherapie
  • Medizinisches Versorgungszentrum Aue
  • Helios Kliniken Bad Saarow Klinik für Radioonkologie
  • HELIOS Klinikum Bad Saarow
  • Strahlentherapie Klinikum Bayreuth
  • MVZ Chariete Vivantes Gmbh Strahlentherapie
  • Medizinisches Versorgungs Zentrum Diagnostisch Therapeutisches Zentrum am Frankfurter Tor
  • Strahlentherapie in Moabit /Praxis für Strahlentherapie
  • Praxis für Radioonkologie und Strahlentherapie Berlin Südwest
  • Ambulantes Gesundheitszentrum der Dr. med Maria Sternemann Charte -Universitätsmedizin Berlin
  • Vivantes-Klinikum Berlin-Neukölln
  • HELIOS Klinikum Berlin-Buch, Strahlentherapeutische Klinik
  • Charite berlin (Virchow) Klinik für Strahlentherapie
  • DRK Kliniken Berlin: Zentrum für Strahlentherapie MVZ pro patiente Westend
  • MZV am HELIOS Klinikum Emil von Behring
  • Gemeinschaftspraxis und Belegabteilung für Strahlentherapie
  • Ambulanz Bremen GMBH MVZ RadioOnkologie
  • Zentrum für Strahlentherapie undRadioonkologie
  • Krankenhaus Buchholz Abteilung für Strahlentherapie
  • Strahlentherapie Coesfeld
  • Radiologie Strahlentherapie-Zweigpraxis vom MVZ Passau
  • Praxis für Strahlentherapie Krankenhaus Dresden-Friedrichsstadt
  • Malteser MVZ Duisburg-Süd
  • Universitätsklinikum Düsseldorf Klinik und Poliklinik für Strahlentherapie und Radioologische Onkologie
  • Gemeinschaftspraxis für Strahlentherapie und Radioonkologie
  • MVZ Strahlentherapie Klinikum Esslingen GmbH
  • Klinik für Strahlentherapie und Onkologie
  • Klinikum Frankfurt (Oder)Klinikum für Strahlentherapie Radioonkologie
  • Strahlentherapie am Klinikum Fürth
  • Strahlentherapiezentrum- Escher-Lippe(STZELL) und die Katholischen Kliniken-Emscher
  • Justus-Liebig Universität Gießen Strahlentherapie
  • Praxis für Strahlentherapie Goch
  • Brustzentrum ALB FILS Kliniken GMBH
  • Dr.med Jürgen Heide Facharzt für Strahlentherapie
  • Ambulanzzentrum des UKE GmbH Bereich der Strahlentherapie
  • Radiologische Ambulanz Fachärzte für Radiologie,Nuklearmedizin und Strahlentherapie
  • Strahlenzentrum Hamburg
  • GSR Hameln
  • Gemeinschaftspraxis für Strahlentherapie und Radioonkologie / Hannover/Hildesheim/Hameln
  • GSR Hannover Siloa
  • Gemeinschaftspraxis für Strahlentherapie und Radioonkologie(GSR)
  • Gemeinschaftspraxis für Strahlentherapie Hildesheim/Goslar
  • Gemeinschaftspraxis für Strahlentherapie/Hildesheim/Goslar
  • Strahlentherapie Hof
  • MVZ St. Vincent-Kliniken gAG
  • Praxis für Strahlentherapie am Universitätsklinikum Schleswig-Holstein
  • Universitätsklinikum Schleswig-Holstein
  • Universitätsklinikum Leibzig
  • Klinikum für Strahlentherapie - Klinikum Lippe
  • Klinikum Ludwigsburg Klinik für Radioonkologie
  • Klinikum Lüneburg, Klinik für Strahlentherapie und Radioonkologie
  • MVZ Prof.Dr.Uhlenbrock und Partner Strahlentherapie Lünen
  • Klinik und Poliklinik für Radioonkologie und Strahlentherapie Universitätsmedizin der Johannes Gutenberg-Universität Mainz
  • Praxis für Strahlentherapie Mannheim
  • Universitätsklinikum Marburg Strahlentherapie und Radioonkologie
  • Brustzentrum Helios Klinikum
  • Kliniken Maria Hilf Gmbh Klinik für Strahlentherapie
  • Klinikum rechts der Isar
  • Klinik für Strahlentherapie- Radioonkologie
  • Praxis für Strahlentherapie und Radioonkologie am Clemenshospital
  • Strahlentherapie Neckarsulm
  • Dietrich Bonhoeffer Klinikum Neubrandenburg
  • Praxis für Strahlentherapie Im Städtischen Klinikum Neunkirchen
  • Klinik für Strahlentherapie und Radioonkologie Pius-Hospital Oldenburg
  • Zentrum für Strahlentherapie Rheine-Osnabrück
  • MVZ Radio-LOG Schie in Altötting
  • Visiorad - Bereich Strahlentherapie
  • Klinikum für Radioonkologie Klinikum Ernst von Bergmann
  • Krankenhaus Barmherzige Brüder Regensburg Medizinisches Versorgungszentrum
  • Überörtliche Gemeinschaftspraxis/Fachärzte für Strahlentherapie
  • Kreiskliniken Esslingen Paracelsus Krankenhaus Ruit
  • CaritasKlinikum Saarbrücken
  • XCare Praxis für Strahlentherapie
  • MVZ Leopoldina Strahlentherapie
  • MVZ Leopoldina
  • Helios kliniken Schwerin GMBH
  • Johanniter Zentren für medizinische Versorgung in der Altmark GMBH
  • Johanniter Zentrum für Medizinische Versorgung
  • MVZ Klinikum Straubing GMBH Strahlentherapie
  • MVZ-Uniklinik Tübingen gGmbH
  • Praxis für Strahlentherapie Trier Ehrang
  • Universitätsklinikum Tübingen
  • Klinik für Strahlentherapie und Radioonkologie Universitätsklinikum Ulm
  • Klinik für Strahlentherapie und Radioonkologie Schwarzwald-Baar -Klinikum
  • Praxis für Strahlentherapie und Radioonkologie am Krankenhaus Weilheim
  • Medizinisches Versorgungszentrum Wolfsburg GmbH
  • Universitätsklinikum Würzburg Klinik und Poliklinik für Strahlentherapie
  • Heinrich-Braun-Klinikum Zwickau

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Standard radiation

Hypofractionation with SIB

Arm Description

Conventionally fractionated radiotherapy of the breast followed by a tumor bed boost sequentially or Conventionally fractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed or Hypofractionated radiotherapy of the breast followed by a tumor bed boost sequentially

Hypofractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed

Outcomes

Primary Outcome Measures

Progression free survival
any local or regional recurrence or distant metastasis or death

Secondary Outcome Measures

Time to occurence of local recurrence
ipsilateral in-breast recurrence
Overall survival
death
Safety and side effects (Number of Patients with Adverse Events)
Number of Patients with Adverse Events
Acute and chronic toxicity (NCI-CTCAE)
All dimensions of NCI-CTCAE
Cosmetic results (NCI-CTCAE)
NCI-CTCAE

Full Information

First Posted
June 4, 2015
Last Updated
August 19, 2021
Sponsor
University Hospital Schleswig-Holstein
Collaborators
University of Luebeck
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1. Study Identification

Unique Protocol Identification Number
NCT02474641
Brief Title
Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer
Acronym
HYPOSIB
Official Title
Adjuvant Radiotherapy After Breast-conserving Surgery in Early Breast Cancer: Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation
Study Type
Interventional

2. Study Status

Record Verification Date
August 2021
Overall Recruitment Status
Unknown status
Study Start Date
June 16, 2015 (Actual)
Primary Completion Date
January 8, 2019 (Actual)
Study Completion Date
March 31, 2022 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University Hospital Schleswig-Holstein
Collaborators
University of Luebeck

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Hypofractionation with simultaneous integrated boost has been investigated in a few trials and appears to be safe and feasible. Investigators initiated this multicenter two-armed phase III prospective trial to analyse the non-inferiority of hypofractionation with simultaneous integrated boost in patients with early breast cancer in comparison to standard fractionation.
Detailed Description
Control Arm: Conventionaly fractionated radiotherapy of the breast 28 × 1.8 Gy = 50.4 Gy followed by a tumor bed boost sequentially 5 to 8 × 2.0 Gy = 10.0 Gy to 16.0 Gy, total dose 60.4 Gy to 66.4 Gy. or Conventionaly fractionated radiotherapy of the breast 28 × 1.8 Gy = 50.4 Gy with simultaneous integrated boost to the tumor bed, total dose 28 × 0.3 Gy or 0.45 Gy= 8.4 Gy or 12,6 Gy, total dose 58,8 Gy to 63.0 Gy. or Hypofractionated radiotherapy of the breast 16 × 2.66 Gy = 42.56 Gy followed by a tumor bed boost sequentially 5 to 8 × 2.0 Gy = 10.0 Gy to 16.0 Gy, total dose 52.56 Gy to 58.56 Gy. Experimental Arm: Hypofractionated radiotherapy of the breast 16 × 2.50 Gy with simultaneous integrated boost to the tumor bed, total dose within the boost volume 16 × 3.00 Gy.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Early-Stage Breast Carcinoma
Keywords
Breast cancer, Hypofractionation with SIB, Non-inferiority, adjuvant radiotherapy with simultaneous integrated boost

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
2324 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Standard radiation
Arm Type
Active Comparator
Arm Description
Conventionally fractionated radiotherapy of the breast followed by a tumor bed boost sequentially or Conventionally fractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed or Hypofractionated radiotherapy of the breast followed by a tumor bed boost sequentially
Arm Title
Hypofractionation with SIB
Arm Type
Experimental
Arm Description
Hypofractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed
Intervention Type
Radiation
Intervention Name(s)
Standard Radiation
Intervention Description
Conventionally fractionated radiotherapy of the breast followed by a tumor bed boost sequentially or Conventionally fractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed or Hypofractionated radiotherapy of the breast followed by a tumor bed boost sequentially
Intervention Type
Radiation
Intervention Name(s)
Hypofractionation with SIB
Intervention Description
Hypofractionated radiotherapy of the breast with simultaneous integrated boost to the tumor bed
Primary Outcome Measure Information:
Title
Progression free survival
Description
any local or regional recurrence or distant metastasis or death
Time Frame
3 to 6 years
Secondary Outcome Measure Information:
Title
Time to occurence of local recurrence
Description
ipsilateral in-breast recurrence
Time Frame
3 to 6 years
Title
Overall survival
Description
death
Time Frame
3 to 6 years
Title
Safety and side effects (Number of Patients with Adverse Events)
Description
Number of Patients with Adverse Events
Time Frame
3 to 6 years
Title
Acute and chronic toxicity (NCI-CTCAE)
Description
All dimensions of NCI-CTCAE
Time Frame
1 day, 7 days, end of radiation (last day of radiation and closing visite), 3 months, 6 months, 12 months, 18 months, 24 months, 30 months, 36 months, 42 months, 48 months, 54 months, 60 months, 66 months, 72 months
Title
Cosmetic results (NCI-CTCAE)
Description
NCI-CTCAE
Time Frame
1 day, end of radiation (last day of radiation and closing visite), 3 months, 12 months, 24 months, 36 months, 48 months, 60 months, 72 months

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Histopathologically confirmed breast cancer operated by breast conserving surgery with clear margins independently of further risk factors (positive or high-risk negative lymph node status, estrogen- or progesterone receptor status, Her-2/neu status uPA/PAI-1 criteria) and postoperative systemic therapy (chemotherapy, endocrine, antibody or bisphosphonate therapy were permitted when indicated) Indication to adjuvant radiotherapy including boost radiotherapy Clearly identified primary tumor region preferably by radiopaque clips Primary wound healing after breast conserving therapy without signs of infection Age ≥ 18 years ECOG ≤ 2 Performance Status Written informed consent Compliance regarding treatment appointments and toxicity Linguistic and cognitive ability to understand the questionnaires Exclusion Criteria: Patients operated by mastectomy No indication for boost radiation (e.g. status after IORT) double sided breast cancer Resection margins positive for disease or insufficient identification of the boost volume Indication for radiotherapy of the regional lymph nodes History of prior breast or thoracic radiotherapy Extended postoperative seroma at the beginning of radiotherapy Previously administered radiotherapy not allowing the required dose Pregnant or lactating patients and woman of child bearing potential, who lacked effective contraception treatment history of other cancer or participation in another clinical trial testing radiotherapy or drugs within 4 weeks of the start of treatment. Patients with serious, uncontrolled, physical or cerebrovascular disorders(e.g. myocardial infarction within the last 12 months) or neurologiy or psychiatric disorders thought to adversly affect treatment compliance
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jürgen Dunst, MD
Organizational Affiliation
University Medical Center Schleswig-Holstein (UKSH)
Official's Role
Study Chair
Facility Information:
Facility Name
Gesundheitszentrum St.Marien Gmbh und Klinik für Strahlentherapie
City
Amberg
ZIP/Postal Code
92224
Country
Germany
Facility Name
Medizinisches Versorgungszentrum Aue
City
Aue
ZIP/Postal Code
08280
Country
Germany
Facility Name
Helios Kliniken Bad Saarow Klinik für Radioonkologie
City
Bad Saarow
ZIP/Postal Code
15526
Country
Germany
Facility Name
HELIOS Klinikum Bad Saarow
City
Bad Saarow
ZIP/Postal Code
15526
Country
Germany
Facility Name
Strahlentherapie Klinikum Bayreuth
City
Bayreuth
ZIP/Postal Code
95445
Country
Germany
Facility Name
MVZ Chariete Vivantes Gmbh Strahlentherapie
City
Berlin ( Mitte)
ZIP/Postal Code
10249
Country
Germany
Facility Name
Medizinisches Versorgungs Zentrum Diagnostisch Therapeutisches Zentrum am Frankfurter Tor
City
Berlin
ZIP/Postal Code
10243
Country
Germany
Facility Name
Strahlentherapie in Moabit /Praxis für Strahlentherapie
City
Berlin
ZIP/Postal Code
10559
Country
Germany
Facility Name
Praxis für Radioonkologie und Strahlentherapie Berlin Südwest
City
Berlin
ZIP/Postal Code
12157
Country
Germany
Facility Name
Ambulantes Gesundheitszentrum der Dr. med Maria Sternemann Charte -Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
12200
Country
Germany
Facility Name
Vivantes-Klinikum Berlin-Neukölln
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Facility Name
HELIOS Klinikum Berlin-Buch, Strahlentherapeutische Klinik
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
Charite berlin (Virchow) Klinik für Strahlentherapie
City
Berlin
ZIP/Postal Code
13353
Country
Germany
Facility Name
DRK Kliniken Berlin: Zentrum für Strahlentherapie MVZ pro patiente Westend
City
Berlin
ZIP/Postal Code
14050
Country
Germany
Facility Name
MZV am HELIOS Klinikum Emil von Behring
City
Berlin
ZIP/Postal Code
14165
Country
Germany
Facility Name
Gemeinschaftspraxis und Belegabteilung für Strahlentherapie
City
Bocholt
ZIP/Postal Code
46399
Country
Germany
Facility Name
Ambulanz Bremen GMBH MVZ RadioOnkologie
City
Bremen
ZIP/Postal Code
28205
Country
Germany
Facility Name
Zentrum für Strahlentherapie undRadioonkologie
City
Bremen
ZIP/Postal Code
28239
Country
Germany
Facility Name
Krankenhaus Buchholz Abteilung für Strahlentherapie
City
Buchholz
ZIP/Postal Code
21244
Country
Germany
Facility Name
Strahlentherapie Coesfeld
City
Coesfeld
ZIP/Postal Code
48653
Country
Germany
Facility Name
Radiologie Strahlentherapie-Zweigpraxis vom MVZ Passau
City
Deggendorf
ZIP/Postal Code
94469
Country
Germany
Facility Name
Praxis für Strahlentherapie Krankenhaus Dresden-Friedrichsstadt
City
Dresden
ZIP/Postal Code
01067
Country
Germany
Facility Name
Malteser MVZ Duisburg-Süd
City
Duisburg
ZIP/Postal Code
470530
Country
Germany
Facility Name
Universitätsklinikum Düsseldorf Klinik und Poliklinik für Strahlentherapie und Radioologische Onkologie
City
Dusseldorf
ZIP/Postal Code
40225
Country
Germany
Facility Name
Gemeinschaftspraxis für Strahlentherapie und Radioonkologie
City
Elmshorn
ZIP/Postal Code
25337
Country
Germany
Facility Name
MVZ Strahlentherapie Klinikum Esslingen GmbH
City
Esslingen
ZIP/Postal Code
73730
Country
Germany
Facility Name
Klinik für Strahlentherapie und Onkologie
City
Frankfurt/M
ZIP/Postal Code
60590
Country
Germany
Facility Name
Klinikum Frankfurt (Oder)Klinikum für Strahlentherapie Radioonkologie
City
Frankfurt/Oder
ZIP/Postal Code
15236
Country
Germany
Facility Name
Strahlentherapie am Klinikum Fürth
City
Fürth
ZIP/Postal Code
90766
Country
Germany
Facility Name
Strahlentherapiezentrum- Escher-Lippe(STZELL) und die Katholischen Kliniken-Emscher
City
Gelsenkirchen
ZIP/Postal Code
45899
Country
Germany
Facility Name
Justus-Liebig Universität Gießen Strahlentherapie
City
Gießen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Praxis für Strahlentherapie Goch
City
Goch
ZIP/Postal Code
47574
Country
Germany
Facility Name
Brustzentrum ALB FILS Kliniken GMBH
City
Göppingen
ZIP/Postal Code
73035
Country
Germany
Facility Name
Dr.med Jürgen Heide Facharzt für Strahlentherapie
City
Hamburg Harburg
ZIP/Postal Code
21075
Country
Germany
Facility Name
Ambulanzzentrum des UKE GmbH Bereich der Strahlentherapie
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Radiologische Ambulanz Fachärzte für Radiologie,Nuklearmedizin und Strahlentherapie
City
Hamburg
ZIP/Postal Code
22307
Country
Germany
Facility Name
Strahlenzentrum Hamburg
City
Hamburg
ZIP/Postal Code
22419
Country
Germany
Facility Name
GSR Hameln
City
Hameln
ZIP/Postal Code
31785
Country
Germany
Facility Name
Gemeinschaftspraxis für Strahlentherapie und Radioonkologie / Hannover/Hildesheim/Hameln
City
Hannover
ZIP/Postal Code
30161
Country
Germany
Facility Name
GSR Hannover Siloa
City
Hannover
ZIP/Postal Code
30449
Country
Germany
Facility Name
Gemeinschaftspraxis für Strahlentherapie und Radioonkologie(GSR)
City
Hildesheim
ZIP/Postal Code
31134
Country
Germany
Facility Name
Gemeinschaftspraxis für Strahlentherapie Hildesheim/Goslar
City
Hildesheim
ZIP/Postal Code
31135
Country
Germany
Facility Name
Gemeinschaftspraxis für Strahlentherapie/Hildesheim/Goslar
City
Hildesheim
ZIP/Postal Code
31135
Country
Germany
Facility Name
Strahlentherapie Hof
City
Hof
ZIP/Postal Code
95032
Country
Germany
Facility Name
MVZ St. Vincent-Kliniken gAG
City
Karlsruhe
ZIP/Postal Code
76135
Country
Germany
Facility Name
Praxis für Strahlentherapie am Universitätsklinikum Schleswig-Holstein
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Universitätsklinikum Schleswig-Holstein
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Universitätsklinikum Leibzig
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Klinikum für Strahlentherapie - Klinikum Lippe
City
Lemgo
ZIP/Postal Code
32657
Country
Germany
Facility Name
Klinikum Ludwigsburg Klinik für Radioonkologie
City
Ludwigsburg
ZIP/Postal Code
71640
Country
Germany
Facility Name
Klinikum Lüneburg, Klinik für Strahlentherapie und Radioonkologie
City
Lüneburg
ZIP/Postal Code
21339
Country
Germany
Facility Name
MVZ Prof.Dr.Uhlenbrock und Partner Strahlentherapie Lünen
City
Lünen
ZIP/Postal Code
44534
Country
Germany
Facility Name
Klinik und Poliklinik für Radioonkologie und Strahlentherapie Universitätsmedizin der Johannes Gutenberg-Universität Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
Praxis für Strahlentherapie Mannheim
City
Mannheim
ZIP/Postal Code
68309
Country
Germany
Facility Name
Universitätsklinikum Marburg Strahlentherapie und Radioonkologie
City
Marburg
ZIP/Postal Code
35033
Country
Germany
Facility Name
Brustzentrum Helios Klinikum
City
Meiningen
ZIP/Postal Code
98617
Country
Germany
Facility Name
Kliniken Maria Hilf Gmbh Klinik für Strahlentherapie
City
Monchengladbach
ZIP/Postal Code
41063
Country
Germany
Facility Name
Klinikum rechts der Isar
City
Muenchen
ZIP/Postal Code
81675
Country
Germany
Facility Name
Klinik für Strahlentherapie- Radioonkologie
City
Münster
ZIP/Postal Code
48149
Country
Germany
Facility Name
Praxis für Strahlentherapie und Radioonkologie am Clemenshospital
City
Münster
ZIP/Postal Code
48153
Country
Germany
Facility Name
Strahlentherapie Neckarsulm
City
Neckarsulm
ZIP/Postal Code
74172
Country
Germany
Facility Name
Dietrich Bonhoeffer Klinikum Neubrandenburg
City
Neubrandenburg
ZIP/Postal Code
17022
Country
Germany
Facility Name
Praxis für Strahlentherapie Im Städtischen Klinikum Neunkirchen
City
Neunkirchen
ZIP/Postal Code
66538
Country
Germany
Facility Name
Klinik für Strahlentherapie und Radioonkologie Pius-Hospital Oldenburg
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
Facility Name
Zentrum für Strahlentherapie Rheine-Osnabrück
City
Osnabrück
ZIP/Postal Code
49076
Country
Germany
Facility Name
MVZ Radio-LOG Schie in Altötting
City
Passau
ZIP/Postal Code
94032
Country
Germany
Facility Name
Visiorad - Bereich Strahlentherapie
City
Pinneberg
ZIP/Postal Code
25421
Country
Germany
Facility Name
Klinikum für Radioonkologie Klinikum Ernst von Bergmann
City
Potsdam
ZIP/Postal Code
14467
Country
Germany
Facility Name
Krankenhaus Barmherzige Brüder Regensburg Medizinisches Versorgungszentrum
City
Regensburg
ZIP/Postal Code
93049
Country
Germany
Facility Name
Überörtliche Gemeinschaftspraxis/Fachärzte für Strahlentherapie
City
Rheine
ZIP/Postal Code
48431
Country
Germany
Facility Name
Kreiskliniken Esslingen Paracelsus Krankenhaus Ruit
City
Ruit
ZIP/Postal Code
73760
Country
Germany
Facility Name
CaritasKlinikum Saarbrücken
City
Saarbrucken
ZIP/Postal Code
66113
Country
Germany
Facility Name
XCare Praxis für Strahlentherapie
City
Saarlouis
ZIP/Postal Code
66740
Country
Germany
Facility Name
MVZ Leopoldina Strahlentherapie
City
Schweinfurt
ZIP/Postal Code
97422
Country
Germany
Facility Name
MVZ Leopoldina
City
Schweinfurt
ZIP/Postal Code
97422
Country
Germany
Facility Name
Helios kliniken Schwerin GMBH
City
Schwerin
ZIP/Postal Code
19055
Country
Germany
Facility Name
Johanniter Zentren für medizinische Versorgung in der Altmark GMBH
City
Stendal
ZIP/Postal Code
39576
Country
Germany
Facility Name
Johanniter Zentrum für Medizinische Versorgung
City
Stendal
ZIP/Postal Code
39576
Country
Germany
Facility Name
MVZ Klinikum Straubing GMBH Strahlentherapie
City
Straubing
ZIP/Postal Code
94315
Country
Germany
Facility Name
MVZ-Uniklinik Tübingen gGmbH
City
Stuttgart
ZIP/Postal Code
70176
Country
Germany
Facility Name
Praxis für Strahlentherapie Trier Ehrang
City
Trier
ZIP/Postal Code
54293
Country
Germany
Facility Name
Universitätsklinikum Tübingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Facility Name
Klinik für Strahlentherapie und Radioonkologie Universitätsklinikum Ulm
City
Ulm
ZIP/Postal Code
89081
Country
Germany
Facility Name
Klinik für Strahlentherapie und Radioonkologie Schwarzwald-Baar -Klinikum
City
Villingen-Schwenningen
ZIP/Postal Code
78052
Country
Germany
Facility Name
Praxis für Strahlentherapie und Radioonkologie am Krankenhaus Weilheim
City
Weilheim
ZIP/Postal Code
82362
Country
Germany
Facility Name
Medizinisches Versorgungszentrum Wolfsburg GmbH
City
Wolfsberg
ZIP/Postal Code
38440
Country
Germany
Facility Name
Universitätsklinikum Würzburg Klinik und Poliklinik für Strahlentherapie
City
Würzburg
ZIP/Postal Code
97080
Country
Germany
Facility Name
Heinrich-Braun-Klinikum Zwickau
City
Zwickau
ZIP/Postal Code
08060
Country
Germany

12. IPD Sharing Statement

Citations:
PubMed Identifier
33320286
Citation
Krug D, Vonthein R, Schreiber A, Boicev AD, Zimmer J, Laubach R, Weidner N, Dinges S, Hipp M, Schneider R, Weinstrauch E, Martin T, Horner-Rieber J, Olbrich D, Illen A, Hessler N, Konig IR, Dellas K, Dunst J. Impact of guideline changes on adoption of hypofractionation and breast cancer patient characteristics in the randomized controlled HYPOSIB trial. Strahlenther Onkol. 2021 Sep;197(9):802-811. doi: 10.1007/s00066-020-01730-9. Epub 2020 Dec 15.
Results Reference
background

Learn more about this trial

Hypofractionation With Simultaneous Integrated Boost vs. Standard Fractionation in Early Breast Cancer

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