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Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

Primary Purpose

Bradyarrhythmia

Status

Unknown status

Phase

Locations

Taiwan

Study Type

Observational

Intervention

About this trial

This is an observational trial for Bradyarrhythmia

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

The patients with non-familial bradyarrhythmia

Exclusion Criteria:

Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases

Sites / Locations

China Medical University HospitalRecruiting
China Medical University HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Arm Label

sinus node dysfunction

Atrioventricular block

control

Arm Description

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT01310907

First Posted

March 6, 2011

Last Updated

March 6, 2011

Sponsor

China Medical University Hospital

Collaborators

China Medical University, China

1. Study Identification

Unique Protocol Identification Number

NCT01310907

Brief Title

Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

Study Type

Observational

2. Study Status

Record Verification Date

March 2011

Overall Recruitment Status

Unknown status

Study Start Date

February 2011 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

China Medical University Hospital

Collaborators

China Medical University, China

4. Oversight

5. Study Description

Brief Summary

Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia. Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Bradyarrhythmia

7. Study Design

Enrollment

400 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

sinus node dysfunction

Arm Title

Atrioventricular block

Arm Title

control

10. Eligibility

Sex

All

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: The patients with non-familial bradyarrhythmia Exclusion Criteria: Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases

Study Population Description

The case group include 200 patients and the control group include 200 patients.

Sampling Method

Probability Sample

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Jan-Yow Chen, MD

Phone

+422052121

Ext

2311

janyow@ms77.hinet.net

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Jan-Yow Chen, MD

Organizational Affiliation

China Medical University Hospital

Official's Role

Principal Investigator

Facility Information:

Facility Name

China Medical University Hospital

City

Taichung

ZIP/Postal Code

404

Country

Taiwan

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Jan-Yow Chen, MD

Phone

+88622052121

Ext

2311

janyow@ms77.hinet.net

First Name & Middle Initial & Last Name & Degree

Jan-Yow Chen, MD

Facility Name

China Medical University Hospital

City

Taichung

ZIP/Postal Code

404

Country

Taiwan

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Jan-Yow Chen, MD

Phone

+886-4-22052121

Ext

2311

janyow@ms77.hinet.net

First Name & Middle Initial & Last Name & Degree

Jan-Yow Chen, MD

12. IPD Sharing Statement

Citations:

PubMed Identifier

10706901

Citation

Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.

Results Reference

background

Links:

URL

http://www.hrsonline.org/

Description

Heart Rhythm Society

Learn more about this trial

Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

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