Identifying Strategies to Alleviate Cardiovascular Stress in Coronary Patients During Heatwaves
Coronary Artery Disease
About this trial
This is an interventional basic science trial for Coronary Artery Disease
Eligibility Criteria
Inclusion Criteria:
- History of angiographic coronary disease (≥70% arterial diameter narrowing of at least one major epicardial coronary artery) and/or prior coronary revascularization and/or documented prior acute coronary syndrome and/or stable angina and/or perfusion defect during exercise testing.
- No CAD-related hospitalisations or changes in cardiac medications or change in pattern of angina for at least 3 months prior to enrolment
Exclusion Criteria:
- Body mass index ≥35 kg/m2.
- Currently undertaking estrogen therapy.
- Evidence of current fluid and electrolyte disorders, anemia, abnormal thyroid function, arrhythmias, diabetes, renal disease, liver disease, cerebrovascular disease, significant pulmonary disease, endocrine abnormalities, significant cognitive impairment, psychiatric disorder, substance abuse, degenerative neurological condition or any other medical condition deemed to pose risk during the proposed experiments.
- Uncontrolled hypertension (>180/110 mmHg).
- Recent (<3 months) coronary bypass surgery.
- Ejection fraction <40% and/or clinical evidence/history of heart failure.
- Significant valvular heart disease
- Resting ECG abnormalities interfering with observation of ST segment changes during testing.
Sites / Locations
- cardiovascular Prevention and rehabilitation Centre of the Montreal Heart Institute
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
38°C and 60% RH + No intervention
38°C and 60% RH + Fan
38°C and 60% RH + Skin wetting
38°C and 60% RH + Fan + Skin wetting
46°C and 10% RH + No intervention
46°C and 10% RH + Skin wetting
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
The participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
Tthe participant will enter an environmental chamber maintained at 38°C and 60% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.
The participant will enter an environmental chamber maintained at 46°C and 10% relative humidity.
The participant will enter an environmental chamber maintained at 46°C and 10% relative humidity. The participant will remain within the environmental chamber and will rest in a seated position for 3 hours.