Immediate Versus Delayed Treatment of Odontogenic Infections
Focal Infection, Dental
About this trial
This is an interventional treatment trial for Focal Infection, Dental focused on measuring Dentistry, Antibiotic, Penicillin, pediatrics
Eligibility Criteria
Inclusion Criteria:
- Patients who present to the dental clinic or Boston Children's Hospital emergency room
- Odontogenic origin associated with a primary tooth and limited to the buccal vestibule only
- Ages of 2-11 years old
- Primary Caregiver present
- English speaking
- American Society of Anesthesiologists (ASA) classification of I
- None or current systemic antibiotic therapy regimen < 24 hours
- Able to take medication orally
- Those patients who choose to participate in the study
Exclusion Criteria:
- Infection that has spread beyond the buccal vestibule, or not detectable
- Infection is associated with a permanent adult tooth
- Ages of <2 years old or >11 years old
- American Society of Anesthesiologists classification of II or greater or poor general health.
- Renal impairment
- Immunosuppressive disease
- Recent antibiotic therapy in the last 1 to 30 days
- Allergy to penicillin
- Unable to take oral medications
- Decline participation
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Extraction Only
Average Dose Antibiotic
High Dose Antibiotic
Immediate extraction of infected tooth without antibiotic prescription.
Average dose antibiotic therapy(25 mg/kg/day in divided doses every 12 hours (maximum 875 mg/dose)) for 10 days and receive tooth extraction on day 10 (25 patients). (*given the average weight of a 12 year old is 45 kilos, we do not expect that we will reach the maximum dose in this group)
High dose antibiotic therapy (45 mg/kg/day in divided doses every 12 hours (maximum 875 mg/dose)) for 5 days and receive tooth extraction on day 10 (25 patients)