Immune Therapies and Anti-HIV Therapy Withdrawal in Controlling Viral Load
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Virus Replication, HIV-1, AIDS Vaccines, RNA, Viral, Avipoxvirus, Genetic Vectors, Viral Load, aldesleukin, Antiretroviral Therapy, Highly Active, HIV Therapeutic Vaccine, Treatment Interruption
Eligibility Criteria
Inclusion Criteria Patients may be eligible for this study if they: Are HIV-positive. Are more than 18 years old. Have been receiving their current HAART (2 or more anti-HIV drugs in combination) for more than 6 consecutive months. Have a CD4 count of 200 cells/microL or more within the 12 months prior to entering the study and 400 cells/microL or more on 2 occasions at least 2 weeks apart within 30 days of entry. Have never had a viral load higher than 2 million molecules/ml and have had the viral load controlled with HAART to less than 50 molecules/ml on 2 occasions at least 2 weeks apart within 30 days of entry. Have not had virologic failure on the current HAART regimen. Have a negative urine pregnancy test within 14 days of entering the study. Exclusion Criteria Patients will not be eligible for this study if they: Have a current AIDS-defining illness. Have had failure of the current HAART regimen (viral load higher than 10,000 molecules/ml). Have a history of using agents affecting the immune system. Have active uncontrolled heart disease. Have had IL-2 therapy within 4 weeks of entering the study. Have received other treatment that affects the immune system within 4 weeks of entry. Have a history of a cancer requiring chemotherapy. Have untreated thyroid disease, within 4 weeks of entering the study. Have uncontrolled allergic disorders or autoimmune diseases, including asthma, inflammatory bowel disease, and psoriasis. Abuse substances that may interfere with the ability to follow study requirements. Are allergic to eggs. Have hepatitis B or hepatitis C. Are pregnant or breast-feeding. Work in close contact with canaries, such as a job at breeding farms or bird shops.
Sites / Locations
- New York Hosp - Cornell Med Ctr