Immuno-nutrition Supplementation in Haemodialysis
Chronic Kidney Disease Requiring Chronic Dialysis
About this trial
This is an interventional treatment trial for Chronic Kidney Disease Requiring Chronic Dialysis focused on measuring Haemodialysis, Systemic inflammation, Skeletal muscle mass, Immuno-nutrition
Eligibility Criteria
Inclusion Criteria: CRP level >5.0 mg/L. At least three haemodialysis sessions per week for ≥3 hours using a biocompatible dialyser. Able to give informed consent. Exclusion Criteria: Treatment with drugs that cause immunosuppression. Non-English speakers or those with special communication needs. Pregnancy, breast feeding or intending pregnancy. Expected survival <6 months. Hospitalisation at the time of screening. Known intolerance or allergy to ONS (or isolated ingredients). Pre-dialysis serum potassium >5.0 mmol/L. Unable to provide informed consent.
Sites / Locations
- Department of Renal Medicine, Royal Derby Hospital
Arms of the Study
Arm 1
Other
Immuno-nutrition
Participants will be advised to take daily one sachet (74 g) of the immuno-nutrition supplement (Oral Impact®, Nestle) dissolved in 125 ml of water and will be followed-up for 6 weeks. Participants will receive individualised (to patient needs and food preferences) dietetic advice formulated and delivered by an experienced renal dietitian under an honorary NHS research contract, who is a member of the research team and will be supervised by an NHS renal dietitian, aiming to achieve estimated nutritional requirements for people on haemodialysis (i.e., energy: 30-35 kcal/kg/day, and protein intake: 1.0-1.2 g/kg/day). Each dietetic advice provided to participants will also be reviewed by the NHS clinical renal dietitians who are members of the participants' usual clinical care team.