Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics (VMD)
Vasodilation, Diabetes Mellitus, Type 2
About this trial
This is an interventional basic science trial for Vasodilation focused on measuring Vibration, Peripheral Artery Hemodynamics, Diabetes Mellitus
Eligibility Criteria
Inclusion Criteria:
- 18 - 80
- Sinus Rhythm in ECG
- Ejection Fraction > %35
- Informed Consent
Exclusion Criteria:
- Unstabile angina
- Certain or suspected subclavian artery or brachial artery atherosclerotic disease (assessed with USG)
- Heart failure ( New York Heart Association III - IV)
- Atrial fibrillation or frequent extrasystoles in ECG.
Sites / Locations
- Istanbul University, Istanbul Faculty of Medicine, Department of Cardiology
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Local Vibration Application Following Flow-Mediated Dilation Application
Flow-Mediated Dilation Application
Flow mediated dilatation will be induced via 5 min cuff inflation below left elbow at suprasystolic pressures (50mmHg above preapplication systolic pressure). Vibration is applied with a commercially available vibration plate to forearm at 20 hz and 3 mm of vertical amplitude for 5 minutes, 30 minutes after termination of FMD.
Flow mediated dilatation will be induced via 5 min cuff inflation below left elbow at suprasystolic pressures (50mmHg above preapplication systolic pressure).