Impact of the Persistence of Inflammation at Doppler Ultrasound Level on the Structural Evolution of Erosion in Rheumatoid Arthritis Treated With Biotherapy
Rheumatoid Arthritis
About this trial
This is an interventional diagnostic trial for Rheumatoid Arthritis focused on measuring Rheumatoid Arthritis, bDMARDs, biotherapy, remission, erosion
Eligibility Criteria
Inclusion Criteria:
- Initial medical examination performed,
- RA diagnosis according to the criteria of the ACR / EULAR 2010
- Low or moderate disease activity with a DAS28 ≤ 4 since at least for 6 months
- Patients with bDMARDs (Remicade®, Enbrel®, Humira®, Cimzia®, Simponi®, Ro-Actemra®, ou Orencia®) since at least 6 months and no change planned by the investigator,
- Patient with at least one erosion on the head of the 2nd or 3rd metacarpal right or left,
- Stable corticosteroids dose since at least 3 months less than or equal to 10 mg of prednisone equivalent,
- Medical care and monitoring in the rheumatology department of the CHU of Saint-Etienne or the Edouard Herriot Hospital in Lyon,
- written consent of patient
Exclusion Criteria:
- Other diagnosis than RA,
- Intravenous or intra-articular injection at the 2nd or 3rd metacarpophalangeal left or right during the 3 months prior to inclusion,
- Surgery provided at the 2nd or 3rd metacarpophalangeal right or left within a year of inclusion,
- Concomitant treatment with zoledronic acid (Aclasta) or denosumab (Prolia®)
- Refusal of blood collection,
- Pregnancy or breastfeeding women,
Sites / Locations
- HCL - Hôpital EdouarD Herriot
- CHU Saint-Etienne
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
active erosion
inactive erosion
HR-pQCT for measure bone parameters in "active erosion" group. The "active erosion" group will be defined by grades 2 and 3, ie by the presence of Doppler signals confluence in less than 50% of the synovial surface (grade 2) and in over 50% of the surface synovial for grade 3
HR-pQCT for measure bone parameters in "active erosion" group. The "inactive erosion" group will be defined by grades 0 and 1, ie the absence of Doppler signal for grade 0 and the presence of some non confluence Doppler signals for the grade 1