Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes (Whey2Glo)
Pre Diabetes
About this trial
This is an interventional prevention trial for Pre Diabetes focused on measuring HbA1c, whey, postprandial glycaemia, cardiometabolic, vascular, leucine, branched chain amino acids (BCAA), glucose control, Milk protein
Eligibility Criteria
Inclusion Criteria:
- BMI 20-35 kg/m2
- HbA1c (5.7 - 6.5%) or (38.8 - 47.5 mmol/mol)
- Fasting glucose 5.5-6.9 mmol/l
- Fasting total cholesterol <7.5mmol/l
- Fasting triacylglycerol <4.0 mmol/l
- Not having a milk, gluten or wheat allergy or lactose intolerability
- Not having diabetes (HbA1c < 47 mmol/mol) or < 6.5%
- Not suffering from cardiovascular, renal, gastrointestinal, respiratory, endocrine or liver disease
- Not having hypertension
- Not diagnosed with cancer
- Not having surgery in the previous 6 months
- Not consuming more than the recommended intake of alcohol (>14 unit/wk)
- Not being a blood donor 3 months prior to or during the study.
- Not taking extra protein powder supplements in the previous 2 months
- Not anaemic (Haemoglobin ≥115 g/l for women and ≥ 130 g/l for men)
- Not taking medication for raised blood lipids, high blood pressure or for inflammatory conditions.
Exclusion Criteria:
• Females who are breast-feeding, may be pregnant, or if of child-bearing potential and are not using effective contraceptive precautions
Sites / Locations
- Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Whey Protein Isolate
Wheat Protein
Wheat protein with leucine
Subjects are asked to supplement their habitual diet with 56 g of whey protein isolate a day for 8 weeks
Subjects are asked to supplement their habitual diet with 56 g of wheat protein a day for 8 weeks
Subjects are asked to supplement their habitual diet with 56 g of wheat protein with leucine a day for 8 weeks