Implementing LISA Surfactant in Nigeria
Respiratory Distress Syndrome, Neonatal Death
About this trial
This is an interventional treatment trial for Respiratory Distress Syndrome
Eligibility Criteria
Inclusion Criteria: Newborns with birth weight between 500-2000 grams (determined by birth weight or admission weight if birth weight is unavailable). ≤48 Hours old at recruitment. Spontaneously breathing but have clinical signs of respiratory distress (defined by Anderson Silverman Score (ASS) ≥4 (range 0-10)) and on CPAP. Admitted to the neonatal/newborn units (or special care nurseries). Exclusion Criteria: Any newborn intubated before admission to the neonatal/newborn units. Any newborn infants with a significant congenital abnormality Any preterm infant considered nonviable by the managing clinician.
Sites / Locations
- Federal Medical Center AsabaRecruiting
- University of Benin Teaching HospitalRecruiting
- National Hospital Abuja
- Aminu Kano Teaching Hospital
- Lagos University Teaching Hospital.
- University of Nigeria Teaching HospitalRecruiting
Arms of the Study
Arm 1
Experimental
LISA Arm
Eligible subjects who have respiratory distress syndrome (Anderson Silverman Score >4) managed on continuous positive airway pressure (CPAP) will receive surfactant via a thin catheter while on CPAP.