Improving Arteriovenous Fistula Patency (METTRO)
Thrombosis
About this trial
This is an interventional prevention trial for Thrombosis focused on measuring Thrombosis, Arteriovenous fistulae, Hemodialysis, Doppler ultrasound, Vascular access blood flow, Surveillance
Eligibility Criteria
Inclusion Criteria:
- Informed consent signature.
- Age between 18 and 95 years old.
- Functioning native AVF.
- Patients with end stage renal disease (ESRD) undergoing hemodialysis program for at least three months.
Exclusion Criteria:
- Coagulopathy or hemoglobinopathy of any cause.
- Hospitalization of any cause in the previous month.
- VA related complications or dysfunction in the previous three months.
Sites / Locations
- Hospital Universitario Infanta Sofia
- Centro de Diálisis Los Enebros
- Hospital Universitario Gregorio Marañon
- Dialcentro
- Clinica Fuensanta
Arms of the Study
Arm 1
Arm 2
Other
Experimental
Clasical Surveillance of AVF
Second generation surveillance of AVF
Classical evaluation of AVF includes: Vital sings and predialysis physical examination of AVF every dialysis session. Effective blood flow, venous pressure, arterial pressure, at the beginning and at the end of the dialysis session. Weekly ktv test using biosensors or monthly if using monocompartimental Daugirdas equation. Quarterly recirculation with urea method. Following Spanish Nephrology VA guidelines will be consider as alarm criteria: 1.25% Increased venous pressure. 2.25% Decreased pump blood flow. 3.0,2 ktv decreased compared with previous measurement. 4.> 10% recirculation using urea method. 5.Prolonged coagulation time or cannulation difficulties in 3 consecutive dialysis sessions. 6.Pathologic physical examination with any other criteria.
In addition to the classical surveillance and monitoring methods, in the experimental group Doppler ultrasound and transonic dilution method will be performed on a quarterly basis. In addition to the classical alarm criteria and derived from the results in Doppler ultrasound an transonic dilution method the following alarm criteria would also be considered in the experimental group: 25% or higher decreased in QA compared with previous measurement. QA lower than 500 ml/min. Stenotic area with a higher than 50% reduction of blood vessel lumen would be considered as alarm criteria only if it comes with a haemodynamic repercussion criteria defined as Peak systolic velocity (PSV) higher than 400 cm/sc, aliasing, or PSV ratio stenosis/pre-stenosis higher than 3.