Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2) (VANCAPP)
Sepsis, Infections, Bacteremia
About this trial
This is an interventional treatment trial for Sepsis
Eligibility Criteria
Inclusion Criteria: Infants aged 0 - 90 days old Suspected infection requiring treatment with vancomycin for 48 hours or more (as determined by the clinical team) Exclusion Criteria: Infants with a corrected gestational age of less than 25 weeks Infants weighing less than 500g. Known allergy to any glycopeptide antibiotic Vancomycin administered within the previous 72 hours Infants receiving any form of extracorporeal life support Renal impairment
Sites / Locations
- Royal Children's Hospital Melbourne
- Monash Newborn
- Royal Hospital for Women
- The Children's Hospital at Westmead
Arms of the Study
Arm 1
Experimental
Vancomycin first-dose trough dose adjustment calculation
Participants will have individualised model-based intermittent vancomycin dosing using the Vanc App dosing calculator (as used in VANC APP Part 1, see clinicaltrials.gov ID: NCT04044703). A first-dose trough concentration will be measured for each participant and the clinician will then enter that concentration into the web application ('First-dose trough dose adjustment calculator'). A dose adjustment will be generated by the calculator if the predicted steady-state level is outside of target range. If the predicted steady-state level is within target range (10-20mg/L) the calculator will recommend continuing with the same dose. The vancomycin concentration is then measured at steady state to determine if the target concentration has been achieved.