IMT in Ventilatory Muscle Metaboreflex in COPD
Chronic Obstructive Pulmonary Disease
About this trial
This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease focused on measuring Pulmonary Rehabilitation, Inspiratory Muscle Training, Inspiratory Muscle Strength, Vascular Resistance, Exercise, Chronic Obstructive Pulmonary Disease
Eligibility Criteria
Inclusion Criteria:
Selection of subjects will be made through the Hospital de Clinicas de Porto Alegre Pneumology Service's COPD ambulatory. The inclusion criteria consist of -patients with COPD with functional confirmation through spirometry as by previously defined criteria.
Those selected must be classified as GOLD II-IV, with moderate to severe expiratory flow obstruction.
Exclusion Criteria:
Patients will be considered ineligible for this study if they
- develop COPD exacerbation 8 weeks prior to recruitment
- if systemic corticosteroids are utilized (in the last three months)
- if there is history of acute myocardial infarction (in the last three months)
- if there is presence of neuromuscular disease
- history of cardiovascular disease or active smoking (in the last 6 months)
- clinical history of peripheral vascular disease and if age is equal or superior to 85 years
Sites / Locations
- Hospital de Clinicas de Porto Alegre
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Inspiratory Muscle Training (IMT)
Sham IMT
Patients from the inspiratory muscle training group will utilize a linear pressoric resistance equipment with an inspiratory charge of 30% of maximum inspiratory pressure (adjusted weekly), during 7 days of the week, session duration of 30 minutes, during 8 weeks.
Patients in the placebo group will be submitted to inspiratory muscle training with the same equipment as the intervention group, however without a resistance generating spring.