Influence of Apelin Levels on Postoperative Cognitive Disorders After Orthopedic Surgery in Elderlies (APOCOGNIT) (APOCOGNIT)
Delirium
About this trial
This is an interventional diagnostic trial for Delirium focused on measuring Postoperative cognitive disorders POCD, inflammation, Surgery
Eligibility Criteria
Inclusion Criteria:
- Patients submitted to a programed orthopedic surgery
- Patients with pre- and post-surgery check-up.
Exclusion Criteria:
- Non programed orthopedic surgery (emergency)
- Patients with sepsis
- Patients submitted to orthopedic surgery but with ambulatory management.
- Existence of justice backup, curators or supervision.
- Absence of indication for a pre- or post-surgery check-up.
Sites / Locations
- CHU Toulouse, service d'orthopédie et traumatologie
Arms of the Study
Arm 1
Experimental
Patients with orthopedic surgery
Patients will be included in the consultation of anesthesia. The usual laboratory tests will be carried out and a determination of apelin and inflammatory cytokines. Assessment of cognitive functions using the Informant Questionnaire on Cognitive Decline in the Elderly (ICQODE), Mini Mental State examination (MMS) and the scale of Instrumental activities of daily living (IADL). Day of surgery: liquid sampling cerebrospinal. Day 1 to day 7 postoperatively: determination of inflammatory cytokines and apelin, postoperative delirium research (Confusion Assessment Method (CAM)), residual cognitive dysfunction research (MMS, IADL, IQCODE). 3 months after operation: evaluation of cognitive performance (IQCODE, IADL)