Influence of Bionecteurs on Catheter-associated Infection (Bionect)

Bionecteur® is a protective non-touch applicator to ensure aseptic connection made by Vygon. However, there are no studies describing a positive effect of using Bionecteurs ® in regard to catheter-related bloodstream infections. In this study Bionecteur® will be used on central venous lines and arterial lines in postoperative patients of a 40-bed ICU. The incidence of catheter-related bloodstream infections will we compared to patients without inclusion of Bionecteur® devices.

Prospective, randomised observational study Postsurgical patients in an anesthesiological ICU with ICU LOS (LOS: length of stay) > 3 days Inclusion: ---- Age ≥ 18 years ---. demand of central venous and arterial line --- written consent of patient and/or assignee Exclusion Handicapped patients patient with ICU LOS < 3 days Study design Three days after admission to ICU blood cultures are drawn to exclude preexisting blood stream infection Patients in a bed with even number are assigned to Bionecteur® group. Control group (without using bionecteurs) are patients with an odd bed number. Biconecteurs® are connected to all lumens of the central catheter and to arterial catheter. Control group is treated without using Bionecteurs®. Handling of vascular catheters are performed as described in institutional guidelines in both groups. Catheter-related bloodstream infections are monitored by an independent person during ICU treatment The study will be finished ab discharge of ICU or removal of catheters.

Inclusion Criteria: Length of Stay (LOS) in ICU > 3 days written consent by patient or notarial carers medical indication for central venous line/arterial line Exclusion Criteria: handicap LOS ICU < 3 days no consent

Koeppen M, Weinert F, Oehlschlaeger S, Koerner A, Rosenberger P, Haeberle HA. Needle-free connectors catheter-related bloodstream infections: a prospective randomized controlled trial. Intensive Care Med Exp. 2019 Dec 2;7(1):63. doi: 10.1186/s40635-019-0277-7.