Back to resultsInfluence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
Primary Purpose
Ischemic Heart Disease
Status
Completed
Phase
Not Applicable
Locations
Sweden
Study Type
Interventional
Intervention
Inhaled anaesthetic agent
Sponsored by
About this trial
This is an interventional basic science trial for Ischemic Heart Disease
Eligibility Criteria
Inclusion Criteria:
- elective coronary artery by-pass graft surgery
- elective valve replacement surgery
- normal left ventricular ejection fraction on preoperative echocardiography
Exclusion Criteria:
- obstructive lung disease
- restrictive lung disease
Sites / Locations
- Skane University Hospital Lund, Cardiothoracic Intensive Care
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Inhaled anaesthetic agent
Arm Description
The group where the investigators adds inhaled anaesthetic agent when using the anaesthetic gas reflector (AnaConda).
Outcomes
Primary Outcome Measures
Volume of carbon dioxide rebreathing from an anesthetic gas reflector
Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas.
Secondary Outcome Measures
Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector.
Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01699802
Brief Title
Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
Official Title
Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
Study Type
Interventional
2. Study Status
Record Verification Date
May 2015
Overall Recruitment Status
Completed
Study Start Date
September 2012 (undefined)
Primary Completion Date
December 2014 (Actual)
Study Completion Date
December 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Region Skane
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent.
The hypothesis is that addition of inhaled anaesthetic agent will affect the amount of adsorption of carbon dioxide to the active carbon and thereby affect rebreathing of carbon dioxide.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Ischemic Heart Disease
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
12 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Inhaled anaesthetic agent
Arm Type
Experimental
Arm Description
The group where the investigators adds inhaled anaesthetic agent when using the anaesthetic gas reflector (AnaConda).
Intervention Type
Other
Intervention Name(s)
Inhaled anaesthetic agent
Primary Outcome Measure Information:
Title
Volume of carbon dioxide rebreathing from an anesthetic gas reflector
Description
Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas.
Time Frame
2 hours
Secondary Outcome Measure Information:
Title
Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector.
Description
Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.
Time Frame
2 hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
90 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
elective coronary artery by-pass graft surgery
elective valve replacement surgery
normal left ventricular ejection fraction on preoperative echocardiography
Exclusion Criteria:
obstructive lung disease
restrictive lung disease
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mikael Bodelsson, Professor
Organizational Affiliation
Divison of Surgery, Department of Anaesthesia, Skane University Hospital, Lund, Sweden
Official's Role
Principal Investigator
Facility Information:
Facility Name
Skane University Hospital Lund, Cardiothoracic Intensive Care
City
Lund
ZIP/Postal Code
SE-221 85
Country
Sweden
12. IPD Sharing Statement
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Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)
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