Influence of Marker of Insulin Resistance Upon Hepatitis C Virus (HCV) Treatment Responses to PEG Intron and Rebetol Therapy

Inclusion Criteria: Evidence of chronic hepatitis C infection (viremia) by RT-PCR superquantitative HCV Genotype 1 Liver biopsy within 36 months of enrollment consistent with chronic hepatitis Compensated liver disease with laboratory parameters at entry visit as follows: Hemoglobin values of > 12 gm/dL WBC > 2,500/mm3 Neutrophil count > 1,000/mm3 Platelets > 100,000/mm3 Prothrombin time < 2 seconds prolonged compared to control, or equivalent INR ratio Bilirubin within 20% of the upper limit of normal unless non-hepatitis related factors exists such as Gilbert's syndrome. Albumin > 3.0 g/dL Serum creatinine < 1.4 mg/dL Normal thyroid stimulating hormone (TSH) or thyroid disease clinically controlled Antinuclear antibodies (ANA)< 1:160 FBS < 126 mg/dl No significant co-existing psychiatric disease Free from substance abuse for past 2 years Exclusion Criteria: Previous treatment for HCV. Evidence of being HIV positive. Hypersensitivity to alpha interferon, Peg Intron or Rebetol. Any other causes for chronic liver disease other than chronic hepatitis C besides obesity. Hemoglobinopathies (e.g., Thalassemia) or any other cause of hemolytic anemia. Evidence of advanced liver disease such as a history of or presence of ascites, bleeding varices, or hepatic encephalopathy. Preexisting medical condition that could interfere with the patient's participation in the protocol including: CNS trauma or active seizure disorders requiring medication; diabetes mellitus; serious pulmonary disease; immunologically mediated diseases; gout attack within 12 months; or any medical condition requiring, or likely to require during the course of the study, chronic systemic administration of steroids. Patients with evidence of ischemia on stress testing, an arrhythmia, cardiac failure, coronary surgery, uncontrolled hypertension, angina or a myocardial infarction within 12 months. Patients with a history of organ transplantation will be excluded. Patients taking insulin sensitizing drugs.