Influence of Nutrition in Depression Treatment (INDEPT) (INDEPT)
Major Depressive Disorder - MDD
About this trial
This is an interventional treatment trial for Major Depressive Disorder - MDD focused on measuring Depression, Major Depressive Disorder, Nutritional Intervention, Randomized Controlled Trial, Mediterranean Diet
Eligibility Criteria
Inclusion Criteria: Aged between 18-70 years old Able to understand and provide informed consent Able to read and write Have a diagnosis of MDD (according to ICD-10 F32.0; F32.1; F32.2 criteria) Score on the Beck Depression Inventory-II scale (BDI-II) > 13; Elevated biomarkers of inflammation (CRP > 3mg/l or IL-6 ≥ 2pg/ml ) Able to follow a MedDiet without impeditive physical or religious limitations, allergies or intolerances Under treatment with antidepressant medication for a period of time less than or equal to 6 months Exclusion Criteria: Diagnosis of autoimmune diseases, thyroid dysfunction or cancer Diagnosis of bipolar disorder, psychotic disorders, eating disorders Self-reported acute infection 2 weeks prior to the blood sample collection Pregnancy or lactation Glucocorticoid medication Currently participating in another intervention targeting diet, physical exercise, or MDD treatment
Sites / Locations
- Hospital de Beatriz Ângelo - Hospital de Loures, EPERecruiting
- Centro Hospitalar de Leiria - Hospital Santo AndréRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Interventional Group
Control Group
Interventional group with six nutritional counselling consultations promoting the adherence to the MedDiet and TAU for MDD
Individuals with TAU for MDD