Influence of Vitamin D on Vascular Function in Adolescents and Young Adults With Type 1 Diabetes
Diabetes Mellitus, Type 1
About this trial
This is an interventional treatment trial for Diabetes Mellitus, Type 1 focused on measuring Type 1 Diabetes, Adolescents and Young Adults, Vitamin D, Cardiovascular Disease
Eligibility Criteria
Inclusion Criteria:
- Diagnosed with type 1 diabetes, according to Canadian Diabetes Association guidelines
- Diagnosed with type 1 diabetes for at least 2 years
- Between the ages of 12 and 18 years
Exclusion Criteria:
- Previous organ transplantation
- Diagnosed with familial hypercholesterolemia
- Active smoker
- Receiving lipid lowering medications
- Receiving anti hypertensive medication
- Significant chronic medical illness, including granulomatous disease
- History of hypertension
- BMI >95%tile
- Known renal failure
- HbA1c greater than 12% on two successive occasions
- Known peripheral vascular disease
- Known hypercalcemia
Sites / Locations
- The Hospital for Sick Children
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Vitamin D Sufficient
Vitamin D Deficient
Sufficient is defined as a 25 OH vitamin D level >50 nmol/l measured at baseline. No clinical intervention will be assigned to this group. Subjects will have fasting bloodwork done. Other study measurements to be taken include: height and weight, stage of puberty, blood pressure, vitamin D and calcium intake information, diabetes risk information, demographic information and spot urine sample. We will also do a non-invasive test called a "PAT" or 'peripheral arterial tonometry' to look at the health of your blood vessels.
Deficient is defined as a 25 OH vitamin D level ≤ 37.5 nmol/l. This group will receive Vitamin D. Subjects will have fasting bloodwork done. Other study measurements to be taken include: height and weight, stage of puberty, blood pressure, vitamin D and calcium intake information, diabetes risk information, demographic information and spot urine sample. We will also do a non-invasive test called a "PAT" or 'peripheral arterial tonometry' to look at the health of your blood vessels.