Inhaled Isopropyl Alcohol for Treatment of Nausea
Vomiting, Nausea, Children, Only
About this trial
This is an interventional treatment trial for Vomiting
Eligibility Criteria
Inclusion Criteria:
- Patients with a chief complaint of nausea or vomiting
- Ages 7-178 years, both sexes
- Weight ≥ 15 kg
- Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10
Exclusion Criteria:
- 1. Require IV access
- Inability to breathe in/out through the nose
- Anosmia (self- or parental report)
- Allergy to isopropyl alcohol or ondansetron
- Current or history of alcohol abuse
- Inability to communicate feeling nauseous
- Inability to follow directions regarding taking deep breaths through the nose
- Known prolonged QT interval
- Pregnancy
- Received antiemetics within the last 8 hours
- Currently taking apomorphine
Sites / Locations
- Oishei Children's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
Inhaled Isopropyl Alcohol
Oral Ondansetron
Inhaled Placebo
If the subject is assigned to receive the isopropyl alcohol pad group, an isopropyl alcohol pad (Covidien Webcol 2 ply prep pad, saturated with 70% isopropyl alcohol) will be given to the subject, or the legal guardian. The alcohol pad will be held 1-2 cm under the subject's nares, the subject will be instructed to take deep breaths, inhaling through the nose as frequently as needed during the Emergency Department (ED) stay.
If the subject is assigned to receive ondansetron treatment, subject will be provided with 4 mg ondansetron oral disintegrating tablet (ODT) for treatment.
If the subject is assigned to receive the inhaled placebo, a normal saline pad (Hygea sterile saline wipe) will be given to the subject or the legal guardian. The saline wipe will be held under the subject's nares, the subject will be instructed to take deep breaths, inhaling through the nose as frequently as needed.