Innovative Technologies for the Treatment of Pulmonary and Heart Failure
Cardiogenic Shock, Ventricular Arrythmia, Cardiac Arrest With Successful Resuscitation
About this trial
This is an interventional treatment trial for Cardiogenic Shock focused on measuring Anesthesiology, Cardiothoracic surgery, Nephrology, Perfusion, Efferentology
Eligibility Criteria
Inclusion Criteria:
Patients on an extracorporeal life support system with heart failure:
- Implantation of intravenous ECMO
- Hemodynamic support with vasopressors and/or tonics;
- Procalcitonin level ≥ 1 ng/ml;
- Invasive hemodynamic monitoring;
- Written informed consent.
Patients on an extracorporeal life support system with pulmonary failure:
- IV ECMO implantation
- High levels of venous and arterial CO2 (CO2> 50 mmHg),
- Low paO2, SvO2, SpO2.
- Invasive hemodynamic monitoring;
Written informed consent.
-Patients with left ventricular assistive device implantation:
- LVAD implantation
- Biventricular heart failure IV
- INTERMACS I-III
- Hemodynamic support with vasopressors and/or tonics;
- Procalcitonin level ≥ 0.1 ng/ml;
- Invasive hemodynamic monitoring;
Written informed consent.
-Patients in operations with prolonged artificial circulation, hypothermia and circulatory arrest:
- Hemodynamic support with vasopressors and/or tonics;
- Bypass duration> 120 minutes
- Hypothermia ≤ 25 0С
- Circulatory arrest
- Procalcitonin level ≥ 1 ng/ml;
- Invasive hemodynamic monitoring;
- Written informed consent.
Exclusion Criteria:
Patients on an extracorporeal life support system with heart failure:
- Age less than 18 years old
- Terminal hepatic or renal failure just before the procedure
- Patient's written refusal to participate in the study
Patients on an extracorporeal life support system with pulmonary failure:
- Age less than 18 years old
- Terminal hepatic or renal failure just before the procedure
- Patient's written refusal to participate in the study
Patients with left ventricular assistive device implantation:
- Age less than 18 years old
- Acute hepatic or renal failure just before the procedure
- Patient's written refusal to participate in the study
Patients in operations with prolonged artificial circulation, hypothermia and circulatory arrest:
- Age less than 18 years old
- Terminal hepatic or renal failure just before the procedure
- Patient's written refusal to participate in the study
Sites / Locations
- National Research Center For Cardiac SurgeryRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Intervention team (1/1 group)
Intervention team (1/2 group)
Intervention team (1/3 group)
Intervention team (1/4 group)
Intervention team (2/1 groups)
Intervention team (2/2 groups)
Intervention team (2/3 groups)
Intervention team (2/4 groups)
An extracorporeal hemoperfusion device will be installed in the device of the extracorporeal life support system for heart failure... (10 patients)
An extracorporeal hemoperfusion device will be installed in the device of the extracorporeal life support system for pulmonary failure (10 patients).
An extracorporeal hemoperfusion device will be installed in patients before/during the implantation of a left ventricular accessory (5 patients).
An extracorporeal hemoperfusion device will be installed in patients during operations with prolonged artificial circulation, hypothermia, and circulatory arrest. (25 patients).
An extracorporeal hemoperfusion device will be installed in the device of the extracorporeal life support system for heart failure. (10 patients)
An extracorporeal hemoperfusion device will be installed in the device of the extracorporeal life support system for pulmonary failure. (10 patients)
An extracorporeal hemoperfusion device will be installed in patients before/during the implantation of a left ventricular accessory (5 patients)
An extracorporeal hemoperfusion device will be installed in patients during operations with prolonged artificial circulation, hypothermia, and circulatory arrest. (25 patients)