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Insulin Resistance Intervention After Stroke Trial (IRIS)

Primary Purpose

Stroke, Myocardial Infarction, Diabetes

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
pioglitazone
placebo
Sponsored by
Yale University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Stroke focused on measuring stroke, heart attack, diabetes, pioglitazone, insulin resistance

Eligibility Criteria

40 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria Ages 40 years or greater at the time of randomization. Ischemic stroke or TIA no less than 14 days and no more than 6 months before randomization Documentation of insulin resistance as defined by a value over 3.0 on the Homeostasis Model Assessment of insulin sensitivity (HOMA). Both ability and willingness to provide informed consent. Presence of none of the exclusion criteria. Exclusion Criteria Permanent Exclusions Severely disabling stroke as indicated by an inability to participate in scheduled follow-up activities. Persons whose ischemic stroke or TIA was related to structural cardiac lesion, significant head trauma, proximal arterial dissection or medical instrumentation. Diabetes mellitus as defined by recent use of medication for diabetes as an out-patient (*see note below) or two fasting plasma blood sugars > 126 mg/dL. HgbA1c > 7.0%. Irreversible medical conditions likely to affect short-term survival or ability to participate in the study protocol. These include: Cancer or other chronic disease with poor prognosis (predicted survival of less than four years). Severe neurologic or psychiatric disease that would complicate the evaluation of study outcomes (e.g., dementia or schizophrenia). History of intolerance to any thiazolidinedione. Pregnancy or desire to become pregnant. Oral contraceptive use. Ongoing use of oral corticosteroids. History of heart failure Active liver disease as defined by known liver disease accompanied by cirrhosis, significant cholestasis, portal hypertension, hepatic encephalopathy, hepatic synthetic dysfunction, or expected significant loss of liver function over the course of the study. History of bladder cancer. Current participation in a conflicting clinical trial. A conflicting clinical trial is defined as a trial with any of following: Intervention that is known to affect the incidence of stroke or myocardial infarction. Intervention that is an experimental drug. Outcome that includes stroke or myocardial infarction. Exclusion for participation in another trial. Temporary Exclusions Persons with temporary exclusions may be enrolled as soon as the exclusion has resolved. Alanine aminotransferase (ALT) >2.5 times the upper limit of normal. Hemoglobin <8.5 g/dl. Moderate or severe pitting edema of the feet or legs (IRIS grade 3 or 4). Carotid surgery or carotid stenting procedure scheduled (delay randomization until 2 weeks following procedure).

Sites / Locations

  • University of Alabama
  • University of South Alabama
  • University of Arizona
  • Shanti Clinical Trials (NINDS-CRC site)
  • UCSF-Fresno
  • Scripps Clinic
  • University of Southern California
  • University of California
  • Stanford University
  • University of California-Davis
  • University of California
  • University of California
  • Denver Health and Hospital Authority
  • Hartford
  • Yale University
  • National Rehabilitation Hospital
  • University of Florida
  • University of Florida
  • MIMA Century Research Associates
  • Pines Neurological Associates (NINDS-CRC site)
  • Floria Neurovascular Institute
  • Cook County (Stroger) Hospital
  • Rush University
  • University of Illinois
  • Ingalls Memorial Hospital (NINDS-CRC site)
  • Loyola University Medical Center
  • OSF St. Francis Medical Center
  • Tri-City Neruology (NINDS-CRC site)
  • Indiana Medical Research
  • Associates In Neurology (NINDS-CRC site)
  • Iowa Health Des Moines Clinical Trials Office
  • Ruan Neuroscience Center/Mercy Medical Center
  • University of Iowa
  • Northeast Iowa Medical Education Foundation (NINDS-CRC site)
  • Via Christi Regional Medical Center
  • University of Kentucky Research Foundation
  • Louisiana State University Health Sciences Center
  • Penobscot Bay Neurology
  • Sinai Hospital of Baltimore
  • Johns Hopkins
  • Massachusetts General Hospital
  • Boston University
  • Caritas St. Elizabeth's Medical Center
  • Beth Israel Deaconess
  • Henry Ford Hospital
  • Michigan State University
  • Minneapolis Clinic of Neurology
  • Hattiesburg Clinic (NINDS-CRC site)
  • St. Luke's Brain and Stroke Institute
  • Washington University
  • St. John's Mercy Medical Center
  • St. Louis University
  • Billings Clinic
  • Advanced Neurology Specialists
  • University of Nebraska
  • Dartmouth Hitchcock Medical Center
  • Cooper University Hospital
  • Kessler Medical Rehab Research Corp
  • University of New Mexico
  • Albany Medical Center
  • SUNY Downstate
  • New York Methodist Hospital
  • SUNY Buffalo
  • St. Vincent's Hospital Manhattan
  • Cornell University
  • University of Rochester
  • Southtowns Neurology of WNY (NINDS-CRC site)
  • Burke Medical Research Institute
  • Clinical Research of Winston-Salem
  • Guilford Neurologic Associates
  • Altru Health System
  • University of Cincinnati
  • Case Western Reserve University
  • Metrohealth Medical Center
  • Cleveland Clinic Foundation
  • Ohio State University
  • University of Toledo
  • Oregon Health & Science University
  • Abington Memorial Hospital
  • Lankenau Institute for Medical Research
  • Penn Stat-Hershey Medical Center (NINDS-CRC site)
  • Thomas Jefferson University
  • Temple University
  • Allegheny Singer Research Institute
  • University of Pittsburgh
  • Rhode Island Hospital
  • University of Tennessee
  • Vanderbilt
  • Baylor Research Institute
  • University of Texas, Southwestern
  • Methodist Neurological Institute
  • University of Texas
  • University of Utah
  • University of Vermont
  • University of Virginia
  • Sentara Medical Group
  • University of Wisconsin
  • Marshfield Clinic
  • Medical College of Wisconsin
  • Flinders Medical Centre
  • Royal Prince Alfred
  • John Hunter Hospital (University of Newcastle)
  • Box Hill Hospital (Eastern Health)
  • Western Hospital (University of Melbourne)
  • Austin Health (National Stroke Research Institute)
  • Royal Melbourne Hospital
  • Royal Perth
  • University of Alberta
  • Center for Neurologic Research
  • Vancouver Island Health Research Centre
  • Robarts Research Institute
  • Ottawa Hospital-General Campus
  • Intermountain Research Consultants
  • St. Michael's Hospital
  • Hôpital Charles LeMoyne
  • McGill-Montreal General
  • McGill-Jewish General
  • Centre Hospitalier Affilie Universitaire de Quebec
  • CHUM-Centre de recherche, Hôpital Notre-Dame
  • Klinikum Altenburger Land
  • Neurologische Klinik
  • University Hospital-Dresden
  • University Duesseldorf/Heinrich-Heine University
  • University of Erlangen
  • Alfried Krupp Hospital
  • University Hospital Frankfurt
  • Freiburg University
  • Ernst-Moritz-Arndt-University Greifswald
  • Martin-Luther-Universitaet Halle-Wittenberg
  • University Medical Center Hamburg-Eppendorf
  • University Heidelberg
  • Friedrich Schiller-University Jena
  • University Hospital Mainz
  • University Hospital Muenster
  • Klinikum der Universitat Muenchen
  • University of Ulm
  • Soroka Medical Center
  • B'nai Zion Medical Center
  • Bnai-Zion Medical Center
  • Rambam Medical Center
  • Wolfson Medical Center
  • Rabin Medical Center-Golda Campus
  • Sheba Medical Center
  • Tel Aviv Medical Center
  • Genoa University Hospital
  • University of Laquila
  • University Vita Salute San Raffaele
  • IRCCS FONdazione Istituto Neurologico C. Mondino
  • University of Perugia
  • University of Rome (S. Andrea Hospital)
  • University of Rome La Sapienza
  • Sacred Heart Catholic University
  • Jazzolino Hospital
  • University of Puerto Rico
  • Royal Bournemouth
  • Queen Elizabeth The Queen Mother Hospital
  • Blackpool Victoria Hospital
  • Wansbeck General Hospital
  • Stobhill Hospital
  • Glasgow Royal Infirmary
  • Southern General Hospital
  • Queen Elizabeth Hospital Gateshead
  • Aberdeen Royal Infirmary
  • Monklands Hospital
  • William Harvey Hospital
  • Royal United Hospital
  • Addenbrookes Foundation NHS Trust (Cambridge)
  • Countess of Chester Foundation Trust
  • Dewsbury District Hospital
  • Southend University Hospital
  • Devon PCT
  • Royal Devon and Exeter
  • Royal Surrey County Hospital
  • Calderdale Royal Hospital
  • The Royal Liverpool and Broadgreen University Hospitals
  • University Hospital Aintree
  • Kings College London
  • Saint Georges University of London
  • Luton and Dubstable Hospital
  • James Cook University Hospital
  • Newcastle upon Tyne
  • Torbay Hospital (South Devon Healthcare NHS Foundation Trust)
  • North Tyneside General Hospital

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Pioglitazone

Placebo

Arm Description

pioglitazone

inactive substance

Outcomes

Primary Outcome Measures

Recurrent Fatal or Non-fatal Stroke, or Fatal or Non-fatal Myocardial Infarction

Secondary Outcome Measures

Fatal or Non-fatal Stroke Alone
Acute Coronary Syndrome
Fatal or non-fatal acute myocardial infarction or unstable angina
Development of Overt Diabetes
All Cause Mortality
Decline in Cognitive Status
Change in modified mental status examination (3MS) score from baseline to exit. Theoretical range of 3MS scores is 0-100. Baseline scores ranged from 22-100.
Composite Outcome of Fatal or Non-fatal Stroke, Fatal or Non-fatal MI or Episode of Serious Congestive Heart Failure

Full Information

First Posted
September 20, 2004
Last Updated
April 14, 2020
Sponsor
Yale University
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS), Takeda Pharmaceuticals North America, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT00091949
Brief Title
Insulin Resistance Intervention After Stroke Trial
Acronym
IRIS
Official Title
Insulin Resistance Intervention After Stroke (IRIS) Trial
Study Type
Interventional

2. Study Status

Record Verification Date
September 2016
Overall Recruitment Status
Completed
Study Start Date
February 2005 (undefined)
Primary Completion Date
November 2015 (Actual)
Study Completion Date
November 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Yale University
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS), Takeda Pharmaceuticals North America, Inc.

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to determine if pioglitazone is effective in preventing future strokes or heart attacks among non-diabetic persons who have had a recent ischemic stroke.
Detailed Description
Among patients throughout the world who experience a transient ischemic attack (TIA)or ischemic stroke, subsequent stroke and heart attack are major causes of death and disability. Within 4 years of the initial TIA or ischemic stroke, 16 percent of patients will have a recurrent stroke and 9 percent will have a heart attack. Prevention of further vascular events, therefore, is critically important to the health of patients with stroke. The IRIS trial will test a new treatment strategy based on evidence linking insulin resistance to increased risk for stroke and other vascular diseases. Insulin resistance is a condition in which insulin, a normal human hormone, does not work effectively because the body is resistant to its effects. This condition can lead to diabetes and is thought to cause blood vessel disease, including stroke and heart attack, in patients with and without diabetes. Insulin resistance affects up to 50% of stroke patients and is effectively modified with thiazolidinedione (TZD) drugs used to treat type 2 diabetes. In addition to reducing insulin resistance, these drugs have other favorable effects on blood vessels, reduce blood vessel inflammation, and potentially prevent atherosclerosis. Currently marketed TZDs include rosiglitazone and pioglitazone. The IRIS is a clinical trial that will enroll 3936 subjects at approximately 170 hospitals in Australia, Canada, Germany, Israel, Italy, the United Kingdom (UK) and the US. After an initial screening blood test, each participant will be randomly assigned to take either pioglitazone or placebo tablets. Recruitment will be completed during 2005-2012, and all participants will be followed for a minimum of 3 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stroke, Myocardial Infarction, Diabetes
Keywords
stroke, heart attack, diabetes, pioglitazone, insulin resistance

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
3876 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Pioglitazone
Arm Type
Active Comparator
Arm Description
pioglitazone
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
inactive substance
Intervention Type
Drug
Intervention Name(s)
pioglitazone
Intervention Description
a thiazolidinedione drug
Intervention Type
Drug
Intervention Name(s)
placebo
Intervention Description
an inactive substance
Primary Outcome Measure Information:
Title
Recurrent Fatal or Non-fatal Stroke, or Fatal or Non-fatal Myocardial Infarction
Time Frame
Up to 5 years
Secondary Outcome Measure Information:
Title
Fatal or Non-fatal Stroke Alone
Time Frame
5 years
Title
Acute Coronary Syndrome
Description
Fatal or non-fatal acute myocardial infarction or unstable angina
Time Frame
5 years
Title
Development of Overt Diabetes
Time Frame
5 years
Title
All Cause Mortality
Time Frame
5 years
Title
Decline in Cognitive Status
Description
Change in modified mental status examination (3MS) score from baseline to exit. Theoretical range of 3MS scores is 0-100. Baseline scores ranged from 22-100.
Time Frame
Annual measures from baseline to exit (up to 5 years)
Title
Composite Outcome of Fatal or Non-fatal Stroke, Fatal or Non-fatal MI or Episode of Serious Congestive Heart Failure
Time Frame
5 years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria Ages 40 years or greater at the time of randomization. Ischemic stroke or TIA no less than 14 days and no more than 6 months before randomization Documentation of insulin resistance as defined by a value over 3.0 on the Homeostasis Model Assessment of insulin sensitivity (HOMA). Both ability and willingness to provide informed consent. Presence of none of the exclusion criteria. Exclusion Criteria Permanent Exclusions Severely disabling stroke as indicated by an inability to participate in scheduled follow-up activities. Persons whose ischemic stroke or TIA was related to structural cardiac lesion, significant head trauma, proximal arterial dissection or medical instrumentation. Diabetes mellitus as defined by recent use of medication for diabetes as an out-patient (*see note below) or two fasting plasma blood sugars > 126 mg/dL. HgbA1c > 7.0%. Irreversible medical conditions likely to affect short-term survival or ability to participate in the study protocol. These include: Cancer or other chronic disease with poor prognosis (predicted survival of less than four years). Severe neurologic or psychiatric disease that would complicate the evaluation of study outcomes (e.g., dementia or schizophrenia). History of intolerance to any thiazolidinedione. Pregnancy or desire to become pregnant. Oral contraceptive use. Ongoing use of oral corticosteroids. History of heart failure Active liver disease as defined by known liver disease accompanied by cirrhosis, significant cholestasis, portal hypertension, hepatic encephalopathy, hepatic synthetic dysfunction, or expected significant loss of liver function over the course of the study. History of bladder cancer. Current participation in a conflicting clinical trial. A conflicting clinical trial is defined as a trial with any of following: Intervention that is known to affect the incidence of stroke or myocardial infarction. Intervention that is an experimental drug. Outcome that includes stroke or myocardial infarction. Exclusion for participation in another trial. Temporary Exclusions Persons with temporary exclusions may be enrolled as soon as the exclusion has resolved. Alanine aminotransferase (ALT) >2.5 times the upper limit of normal. Hemoglobin <8.5 g/dl. Moderate or severe pitting edema of the feet or legs (IRIS grade 3 or 4). Carotid surgery or carotid stenting procedure scheduled (delay randomization until 2 weeks following procedure).
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Walter N. Kernan, M.D.
Organizational Affiliation
Yale University
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Alabama
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294-0007
Country
United States
Facility Name
University of South Alabama
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36617-2293
Country
United States
Facility Name
University of Arizona
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85721-5023
Country
United States
Facility Name
Shanti Clinical Trials (NINDS-CRC site)
City
Colton
State/Province
California
ZIP/Postal Code
92324
Country
United States
Facility Name
UCSF-Fresno
City
Fresno
State/Province
California
ZIP/Postal Code
93702
Country
United States
Facility Name
Scripps Clinic
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
University of Southern California
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
University of California
City
Los Angeles
State/Province
California
ZIP/Postal Code
90095
Country
United States
Facility Name
Stanford University
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304
Country
United States
Facility Name
University of California-Davis
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
University of California
City
San Diego
State/Province
California
ZIP/Postal Code
92103-8466
Country
United States
Facility Name
University of California
City
San Francisco
State/Province
California
ZIP/Postal Code
94143-0114
Country
United States
Facility Name
Denver Health and Hospital Authority
City
Denver
State/Province
Colorado
ZIP/Postal Code
80204-4507
Country
United States
Facility Name
Hartford
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06102-5037
Country
United States
Facility Name
Yale University
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06519
Country
United States
Facility Name
National Rehabilitation Hospital
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010-2949
Country
United States
Facility Name
University of Florida
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32610
Country
United States
Facility Name
University of Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Facility Name
MIMA Century Research Associates
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
Pines Neurological Associates (NINDS-CRC site)
City
Pembroke Pines
State/Province
Florida
ZIP/Postal Code
33026
Country
United States
Facility Name
Floria Neurovascular Institute
City
Tampa
State/Province
Florida
ZIP/Postal Code
33606-3500
Country
United States
Facility Name
Cook County (Stroger) Hospital
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Rush University
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
University of Illinois
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Ingalls Memorial Hospital (NINDS-CRC site)
City
Harvey
State/Province
Illinois
ZIP/Postal Code
60426
Country
United States
Facility Name
Loyola University Medical Center
City
Maywood
State/Province
Illinois
ZIP/Postal Code
60153
Country
United States
Facility Name
OSF St. Francis Medical Center
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61637-0001
Country
United States
Facility Name
Tri-City Neruology (NINDS-CRC site)
City
Saint Charles
State/Province
Illinois
ZIP/Postal Code
60175
Country
United States
Facility Name
Indiana Medical Research
City
Elkhart
State/Province
Indiana
ZIP/Postal Code
46514
Country
United States
Facility Name
Associates In Neurology (NINDS-CRC site)
City
Valparaiso
State/Province
Indiana
ZIP/Postal Code
46383
Country
United States
Facility Name
Iowa Health Des Moines Clinical Trials Office
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50309
Country
United States
Facility Name
Ruan Neuroscience Center/Mercy Medical Center
City
Des Moines
State/Province
Iowa
ZIP/Postal Code
50314
Country
United States
Facility Name
University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52246
Country
United States
Facility Name
Northeast Iowa Medical Education Foundation (NINDS-CRC site)
City
Waterloo
State/Province
Iowa
ZIP/Postal Code
50702
Country
United States
Facility Name
Via Christi Regional Medical Center
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Facility Name
University of Kentucky Research Foundation
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40536-0284
Country
United States
Facility Name
Louisiana State University Health Sciences Center
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71130-3932
Country
United States
Facility Name
Penobscot Bay Neurology
City
Rockport
State/Province
Maine
ZIP/Postal Code
04856
Country
United States
Facility Name
Sinai Hospital of Baltimore
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21209
Country
United States
Facility Name
Johns Hopkins
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287-6953
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114-2695
Country
United States
Facility Name
Boston University
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
Caritas St. Elizabeth's Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02190
Country
United States
Facility Name
Beth Israel Deaconess
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Michigan State University
City
East Lansing
State/Province
Michigan
ZIP/Postal Code
48824
Country
United States
Facility Name
Minneapolis Clinic of Neurology
City
Robbinsdale
State/Province
Minnesota
ZIP/Postal Code
55426
Country
United States
Facility Name
Hattiesburg Clinic (NINDS-CRC site)
City
Hattiesburg
State/Province
Mississippi
ZIP/Postal Code
39401
Country
United States
Facility Name
St. Luke's Brain and Stroke Institute
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64111
Country
United States
Facility Name
Washington University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
St. John's Mercy Medical Center
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
St. Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63220
Country
United States
Facility Name
Billings Clinic
City
Billings
State/Province
Montana
ZIP/Postal Code
59101
Country
United States
Facility Name
Advanced Neurology Specialists
City
Great Falls
State/Province
Montana
ZIP/Postal Code
59405
Country
United States
Facility Name
University of Nebraska
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198
Country
United States
Facility Name
Dartmouth Hitchcock Medical Center
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
Cooper University Hospital
City
Camden
State/Province
New Jersey
ZIP/Postal Code
08013
Country
United States
Facility Name
Kessler Medical Rehab Research Corp
City
West Orange
State/Province
New Jersey
ZIP/Postal Code
07052
Country
United States
Facility Name
University of New Mexico
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87108
Country
United States
Facility Name
Albany Medical Center
City
Albany
State/Province
New York
ZIP/Postal Code
12208
Country
United States
Facility Name
SUNY Downstate
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203
Country
United States
Facility Name
New York Methodist Hospital
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11215
Country
United States
Facility Name
SUNY Buffalo
City
Buffalo
State/Province
New York
ZIP/Postal Code
14209
Country
United States
Facility Name
St. Vincent's Hospital Manhattan
City
New York
State/Province
New York
ZIP/Postal Code
10011
Country
United States
Facility Name
Cornell University
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
University of Rochester
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Facility Name
Southtowns Neurology of WNY (NINDS-CRC site)
City
West Seneca
State/Province
New York
ZIP/Postal Code
14224
Country
United States
Facility Name
Burke Medical Research Institute
City
White Plains
State/Province
New York
ZIP/Postal Code
10605
Country
United States
Facility Name
Clinical Research of Winston-Salem
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Guilford Neurologic Associates
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Altru Health System
City
Grand Forks
State/Province
North Dakota
ZIP/Postal Code
58201
Country
United States
Facility Name
University of Cincinnati
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267-0525
Country
United States
Facility Name
Case Western Reserve University
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106-4938
Country
United States
Facility Name
Metrohealth Medical Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44109-1998
Country
United States
Facility Name
Cleveland Clinic Foundation
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Ohio State University
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
University of Toledo
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43614
Country
United States
Facility Name
Oregon Health & Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239-3098
Country
United States
Facility Name
Abington Memorial Hospital
City
Abington
State/Province
Pennsylvania
ZIP/Postal Code
19001
Country
United States
Facility Name
Lankenau Institute for Medical Research
City
Bryn Mawr
State/Province
Pennsylvania
ZIP/Postal Code
19010
Country
United States
Facility Name
Penn Stat-Hershey Medical Center (NINDS-CRC site)
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Thomas Jefferson University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107-5083
Country
United States
Facility Name
Temple University
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
Allegheny Singer Research Institute
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15212
Country
United States
Facility Name
University of Pittsburgh
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213-2582
Country
United States
Facility Name
Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02905
Country
United States
Facility Name
University of Tennessee
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38163
Country
United States
Facility Name
Vanderbilt
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37212
Country
United States
Facility Name
Baylor Research Institute
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
University of Texas, Southwestern
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390-8897
Country
United States
Facility Name
Methodist Neurological Institute
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Texas
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229-3900
Country
United States
Facility Name
University of Utah
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84132
Country
United States
Facility Name
University of Vermont
City
Burlington
State/Province
Vermont
ZIP/Postal Code
05405
Country
United States
Facility Name
University of Virginia
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Sentara Medical Group
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507
Country
United States
Facility Name
University of Wisconsin
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
Marshfield Clinic
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Facility Name
Medical College of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226-3596
Country
United States
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
New South Wales
ZIP/Postal Code
5042
Country
Australia
Facility Name
Royal Prince Alfred
City
Camperstown
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Facility Name
John Hunter Hospital (University of Newcastle)
City
New Lambton Heights
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Facility Name
Box Hill Hospital (Eastern Health)
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Western Hospital (University of Melbourne)
City
Footscray
State/Province
Victoria
ZIP/Postal Code
3011
Country
Australia
Facility Name
Austin Health (National Stroke Research Institute)
City
Heidelberg Heights
State/Province
Victoria
ZIP/Postal Code
3801
Country
Australia
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Facility Name
Royal Perth
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Facility Name
University of Alberta
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G2B7
Country
Canada
Facility Name
Center for Neurologic Research
City
Lethbridge
State/Province
Alberta
ZIP/Postal Code
T1J0N9
Country
Canada
Facility Name
Vancouver Island Health Research Centre
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R4R2
Country
Canada
Facility Name
Robarts Research Institute
City
London
State/Province
Ontario
ZIP/Postal Code
N6G2V2
Country
Canada
Facility Name
Ottawa Hospital-General Campus
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
k1Y 4E9
Country
Canada
Facility Name
Intermountain Research Consultants
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7B7C7
Country
Canada
Facility Name
St. Michael's Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B1W8
Country
Canada
Facility Name
Hôpital Charles LeMoyne
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
McGill-Montreal General
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G1A4
Country
Canada
Facility Name
McGill-Jewish General
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T1E2
Country
Canada
Facility Name
Centre Hospitalier Affilie Universitaire de Quebec
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1J1Z4
Country
Canada
Facility Name
CHUM-Centre de recherche, Hôpital Notre-Dame
City
Montreal
ZIP/Postal Code
H2L4M1
Country
Canada
Facility Name
Klinikum Altenburger Land
City
Altenburg
ZIP/Postal Code
04600
Country
Germany
Facility Name
Neurologische Klinik
City
Bad Neustadt
ZIP/Postal Code
97616
Country
Germany
Facility Name
University Hospital-Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
University Duesseldorf/Heinrich-Heine University
City
Duesseldorf
ZIP/Postal Code
40225
Country
Germany
Facility Name
University of Erlangen
City
Erlangen
ZIP/Postal Code
91054
Country
Germany
Facility Name
Alfried Krupp Hospital
City
Essen
ZIP/Postal Code
45131
Country
Germany
Facility Name
University Hospital Frankfurt
City
Frankfurt
ZIP/Postal Code
60528
Country
Germany
Facility Name
Freiburg University
City
Freiburg
ZIP/Postal Code
79106
Country
Germany
Facility Name
Ernst-Moritz-Arndt-University Greifswald
City
Griefswald
ZIP/Postal Code
17475
Country
Germany
Facility Name
Martin-Luther-Universitaet Halle-Wittenberg
City
Halle
ZIP/Postal Code
06120
Country
Germany
Facility Name
University Medical Center Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
University Heidelberg
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Friedrich Schiller-University Jena
City
Jena
ZIP/Postal Code
07747
Country
Germany
Facility Name
University Hospital Mainz
City
Mainz
ZIP/Postal Code
55131
Country
Germany
Facility Name
University Hospital Muenster
City
Muenster
ZIP/Postal Code
48149
Country
Germany
Facility Name
Klinikum der Universitat Muenchen
City
Munich
ZIP/Postal Code
81377
Country
Germany
Facility Name
University of Ulm
City
Ulm
ZIP/Postal Code
89081
Country
Germany
Facility Name
Soroka Medical Center
City
Beer Sheva
ZIP/Postal Code
POB151
Country
Israel
Facility Name
B'nai Zion Medical Center
City
Haifa
ZIP/Postal Code
31048
Country
Israel
Facility Name
Bnai-Zion Medical Center
City
Haifa
ZIP/Postal Code
31048
Country
Israel
Facility Name
Rambam Medical Center
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Facility Name
Wolfson Medical Center
City
Holon
ZIP/Postal Code
58100
Country
Israel
Facility Name
Rabin Medical Center-Golda Campus
City
Petach Tikva
ZIP/Postal Code
49372
Country
Israel
Facility Name
Sheba Medical Center
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Facility Name
Tel Aviv Medical Center
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Genoa University Hospital
City
Genoa
ZIP/Postal Code
16132
Country
Italy
Facility Name
University of Laquila
City
Laquila
ZIP/Postal Code
67100
Country
Italy
Facility Name
University Vita Salute San Raffaele
City
Milan
ZIP/Postal Code
20132
Country
Italy
Facility Name
IRCCS FONdazione Istituto Neurologico C. Mondino
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Facility Name
University of Perugia
City
Perugia
ZIP/Postal Code
06100
Country
Italy
Facility Name
University of Rome (S. Andrea Hospital)
City
Roma
ZIP/Postal Code
00189
Country
Italy
Facility Name
University of Rome La Sapienza
City
Rome
ZIP/Postal Code
00161
Country
Italy
Facility Name
Sacred Heart Catholic University
City
Rome
ZIP/Postal Code
00168
Country
Italy
Facility Name
Jazzolino Hospital
City
Vibo Valentia
ZIP/Postal Code
89900
Country
Italy
Facility Name
University of Puerto Rico
City
San Juan
ZIP/Postal Code
00936
Country
Puerto Rico
Facility Name
Royal Bournemouth
City
Bournemouth
State/Province
Dorset
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Facility Name
Queen Elizabeth The Queen Mother Hospital
City
Margate
State/Province
Kent
ZIP/Postal Code
CT9 4AN
Country
United Kingdom
Facility Name
Blackpool Victoria Hospital
City
Blackpool
State/Province
Lancashire
ZIP/Postal Code
FY3 8NR
Country
United Kingdom
Facility Name
Wansbeck General Hospital
City
Ashington
State/Province
Northumberland
ZIP/Postal Code
NE63 9JJ
Country
United Kingdom
Facility Name
Stobhill Hospital
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G21 3UT
Country
United Kingdom
Facility Name
Glasgow Royal Infirmary
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G4 0SF
Country
United Kingdom
Facility Name
Southern General Hospital
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Facility Name
Queen Elizabeth Hospital Gateshead
City
Gateshead
State/Province
Tyne And Wear
ZIP/Postal Code
NE9 6SX
Country
United Kingdom
Facility Name
Aberdeen Royal Infirmary
City
Aberdeen
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Facility Name
Monklands Hospital
City
Airdrie
ZIP/Postal Code
ML6 7UN
Country
United Kingdom
Facility Name
William Harvey Hospital
City
Ashford
ZIP/Postal Code
TN24 OLZ
Country
United Kingdom
Facility Name
Royal United Hospital
City
Bath
ZIP/Postal Code
BA1 3NG
Country
United Kingdom
Facility Name
Addenbrookes Foundation NHS Trust (Cambridge)
City
Cambridge
ZIP/Postal Code
CB2 2QQ
Country
United Kingdom
Facility Name
Countess of Chester Foundation Trust
City
Cheshire
ZIP/Postal Code
CH2 IUL
Country
United Kingdom
Facility Name
Dewsbury District Hospital
City
Dewsbury
ZIP/Postal Code
WF13 4HS
Country
United Kingdom
Facility Name
Southend University Hospital
City
Essex
ZIP/Postal Code
SS0 0RY
Country
United Kingdom
Facility Name
Devon PCT
City
Exeter
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
Royal Devon and Exeter
City
Exeter
ZIP/Postal Code
EX2 5DW
Country
United Kingdom
Facility Name
Royal Surrey County Hospital
City
Guildford
ZIP/Postal Code
GU2 7XX
Country
United Kingdom
Facility Name
Calderdale Royal Hospital
City
Halifax
ZIP/Postal Code
HX3 0PW
Country
United Kingdom
Facility Name
The Royal Liverpool and Broadgreen University Hospitals
City
Liverpool
ZIP/Postal Code
L7 8XP
Country
United Kingdom
Facility Name
University Hospital Aintree
City
Liverpool
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Facility Name
Kings College London
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Saint Georges University of London
City
London
ZIP/Postal Code
SW17 ORE
Country
United Kingdom
Facility Name
Luton and Dubstable Hospital
City
Luton
ZIP/Postal Code
LU4 0DZ
Country
United Kingdom
Facility Name
James Cook University Hospital
City
Middlesbrough
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Facility Name
Newcastle upon Tyne
City
Newcastle upon Tyne
ZIP/Postal Code
NE1 4LP
Country
United Kingdom
Facility Name
Torbay Hospital (South Devon Healthcare NHS Foundation Trust)
City
Torquay
ZIP/Postal Code
TQ2 7AA
Country
United Kingdom
Facility Name
North Tyneside General Hospital
City
Tyne And Wear
ZIP/Postal Code
NE29 2NH
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
Citations:
PubMed Identifier
25458644
Citation
Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Lovejoy AM, Parsons MW, Peduzzi PN, Ringleb PA, Schwartz GG, Spence JD, Tanne D, Young LH, Kernan WN; IRIS Trial investigators. Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. Am Heart J. 2014 Dec;168(6):823-9.e6. doi: 10.1016/j.ahj.2014.07.016. Epub 2014 Jul 28.
Results Reference
background
PubMed Identifier
19365056
Citation
Kernan WN, Viscoli CM, Demarco D, Mendes B, Shrauger K, Schindler JL, McVeety JC, Sicklick A, Moalli D, Greco P, Bravata DM, Eisen S, Resor L, Sena K, Story D, Brass LM, Furie KL, Gutmann L, Hinnau E, Gorman M, Lovejoy AM, Inzucchi SE, Young LH, Horwitz RI; IRIS Trial Investigators. Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs). Neurology. 2009 Apr 14;72(15):1345-51. doi: 10.1212/WNL.0b013e3181a0fda3.
Results Reference
background
PubMed Identifier
21824978
Citation
Kernan W, Viscoli C, Brass L, Amatangelo M, Birch A, Clark W, Conwit R, Furie K, Gorman M, Pesapane B, Kleindorfer D, Lovejoy A, Osborne J, Silliman S, Zweifler R, Horwitz R. Boosting enrolment in clinical trials: validation of a regional network model. Clin Trials. 2011 Oct;8(5):645-53. doi: 10.1177/1740774511414925. Epub 2011 Aug 8.
Results Reference
background
PubMed Identifier
30734043
Citation
Spence JD, Viscoli CM, Inzucchi SE, Dearborn-Tomazos J, Ford GA, Gorman M, Furie KL, Lovejoy AM, Young LH, Kernan WN; IRIS Investigators. Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial. JAMA Neurol. 2019 May 1;76(5):526-535. doi: 10.1001/jamaneurol.2019.0079. Erratum In: JAMA Neurol. 2019 Mar 18;:
Results Reference
derived
PubMed Identifier
29934374
Citation
Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz ES, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN; IRIS Investigators. Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation. 2018 Sep 18;138(12):1210-1220. doi: 10.1161/CIRCULATIONAHA.118.034763.
Results Reference
derived
PubMed Identifier
29084736
Citation
Yaghi S, Furie KL, Viscoli CM, Kamel H, Gorman M, Dearborn J, Young LH, Inzucchi SE, Lovejoy AM, Kasner SE, Conwit R, Kernan WN; IRIS Trial Investigators. Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). Circulation. 2018 Jan 30;137(5):455-463. doi: 10.1161/CIRCULATIONAHA.117.030458. Epub 2017 Oct 30.
Results Reference
derived
PubMed Identifier
28975241
Citation
Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH; Insulin Resistance Intervention After Stroke (IRIS) Trial Investigators. Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 Nov 1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.2136.
Results Reference
derived
PubMed Identifier
28959471
Citation
Stuart AC, Sico JJ, Viscoli CM, Tayal AH, Inzucchi SE, Ford GA, Furie KL, Cote R, Spence JD, Tanne D, Kernan WN. Taking care of volunteers in a stroke trial: a new assisted-management strategy. Stroke Vasc Neurol. 2016 Oct 25;1(3):108-114. doi: 10.1136/svn-2016-000029. eCollection 2016 Sep.
Results Reference
derived
PubMed Identifier
28939682
Citation
Furie KL, Viscoli CM, Gorman M, Ford GA, Young LH, Inzucchi SE, Guarino PD, Lovejoy AM, Conwit R, Tanne D, Kernan WN; IRIS Trial Investigators. Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):21-27. doi: 10.1136/jnnp-2017-316361. Epub 2017 Sep 22.
Results Reference
derived
PubMed Identifier
28246237
Citation
Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN; IRIS Investigators. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. 2017 May 16;135(20):1882-1893. doi: 10.1161/CIRCULATIONAHA.116.024863. Epub 2017 Feb 28.
Results Reference
derived
PubMed Identifier
27935736
Citation
Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy AM, Kernan WN; IRIS Trial Investigators. Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 Mar 1;102(3):914-922. doi: 10.1210/jc.2016-3237.
Results Reference
derived
PubMed Identifier
27465265
Citation
Inzucchi SE, Viscoli CM, Young LH, Furie KL, Gorman M, Lovejoy AM, Dagogo-Jack S, Ismail-Beigi F, Korytkowski MT, Pratley RE, Schwartz GG, Kernan WN; IRIS Trial Investigators. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care. 2016 Oct;39(10):1684-92. doi: 10.2337/dc16-0798. Epub 2016 Jul 27.
Results Reference
derived
PubMed Identifier
26886418
Citation
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR; IRIS Trial Investigators. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. N Engl J Med. 2016 Apr 7;374(14):1321-31. doi: 10.1056/NEJMoa1506930. Epub 2016 Feb 17.
Results Reference
derived
PubMed Identifier
21998067
Citation
Kernan WN, Inzucchi SE. Metabolic rehabilitation: science gathers to support a new intervention to prevent stroke. Stroke. 2011 Dec;42(12):3333-5. doi: 10.1161/STROKEAHA.111.632489. Epub 2011 Oct 13. No abstract available. Erratum In: Stroke. 2012 Mar;43(3):e36.
Results Reference
derived

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Insulin Resistance Intervention After Stroke Trial

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