Insulin Sensitivity and Metabolomics During Oral Administration of Glucose and Graded Intravenous Infusion
Type 2 Diabetes Mellitus
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About this trial
This is an interventional basic science trial for Type 2 Diabetes Mellitus focused on measuring Type 2 Diabetes Mellitus, Impaired glucose tolerance, Metabolomics
Eligibility Criteria
Inclusion Criteria:
- Age between 20 and 65
- BMI between 35 and 60 kg/m2
- Ability to understand and comply with the study process.
Exclusion Criteria:
- History of type 1 diabetes or secondary diabetes;
- Previous bariatric surgery;
- History of medical problems such as mental impairment;
- Major cardiovascular disease;
- Major gastrointestinal disease;
- Major respiratory disease;
- Hormonal disorders;
- Infection;
- History of drug addiction and/or alcohol abuse;
- Internal malignancy;
- Pregnancy;
- Suspected or confirmed poor compliance;
Sites / Locations
- Università Cattolica S. Cuore
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
Patients with normal glucose tolerance
Patients with impaired glucose tolerance
Patients with type 2 diabetes mellitus
Patients included in this arm will have a plasma glucose below 140 mg/dl after a 2 h oral glucose tolerance test with a glucose load of 75 g. All patients in this arm will undergo oral glucose tolerance test with increasing glucose load and a graded intravenous glucose infusion were plasma glucose levels are held at the same level as during the oral glucose tolerance test.
Patients included in this arm will have a plasma glucose between 140 mg/dl to 199 mg/dl after a 2 h oral glucose tolerance test with a glucose load of 75 g. All patients in this arm will undergo oral glucose tolerance test with increasing glucose load and a graded intravenous glucose infusion were plasma glucose levels are held at the same level as during the oral glucose tolerance test.
Patients included in this arm will have a plasma glucose above 200 mg/dl after a 2 h oral glucose tolerance test with a glucose load of 75 g. All patients in this arm will undergo oral glucose tolerance test with increasing glucose load and a graded intravenous glucose infusion were plasma glucose levels are held at the same level as during the oral glucose tolerance test.