Intermittent Hypoxia Paired With High Intensity Training in Brain Injury
Brain Injuries
About this trial
This is an interventional treatment trial for Brain Injuries
Eligibility Criteria
Inclusion Criteria:
- > 6 months post traumatic brain injury
- 18-75 years old
- ability to walk without physical assistance
- Self selected walking speed of 0.01-1.0 m/s
Exclusion Criteria:
- <18 years old
- ->75 years old
- self selected walking speed of > 1.0 m/s
- < 3 months from botulinum toxin injection above the knee brace
- Currently receiving physical therapy
Sites / Locations
- Rehabilitation Hospital of IndianaRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
High Intensity Training with Intermittent Hypoxia
High Intensity Training with Sham Hypoxia
The primary goal will be provide acute intermittent hypoxia (9% PO2; 1 min on 1 min off) prior to stepping training while maintaining HR within 70-85% maximum predicted HR (if patients are deconditioned, PTs will gradually increase intensity to desired levels as tolerated). Sessions will be divided into ~10 minute increments (~25% of sessions) between speed-dependent treadmill training (described above for treadmill stepping), skill-dependent treadmill training, overground training, and stair climbing.
The primary goal will be provide sham intermittent hypoxia (20% PO2) prior to performing continuous stepping while maintaining HR within 70-85% maximum predicted HR (if patients are deconditioned, PTs will gradually increase intensity to desired levels as tolerated). Sessions will be divided into ~10 minute increments (~25% of sessions) between speed-dependent treadmill training (described above for treadmill stepping), skill-dependent treadmill training, overground training, and stair climbing.