Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up

Intra-patient Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT (Optical Coherence Tomography) Follow up

Intra-patient Randomized Study With Polymer Free Drug Eluting Stent Versus Abluminal Biodegradable Polymer Drug Eluting Stent With Early OCT Follow up

The objective of the study is to evaluate the process of early re-endothelialization of the Coroflex® ISAR Drug-eluting stent compared with the Ultimaster® Drug-eluting stent

The objective of the study is to evaluate the process of early re-endothelialization of the Coroflex® ISAR Drug-eluting stent compared with the Ultimaster® Drug-eluting stent

Percentage of early coating on the struts of the Coroflex® ISAR Drug-eluting stent versus Ultimaster® - Drug eluting stent at 3 months OCT after stent implantation.

Number of transversal sections with a percentage (rate of uncovered struts/ total number of struts) > 30 % at 3 months OCT after stent implantation.

Mean thickness of struts tissue coverage at 1 month, 2 months and 3 months OCT after stent implantation.

Target lesion revascularization and target vessel revascularization at 30 days, 3 months, 6 months and 12 months OCT after stent implantation .

Percentage of stents with any malapposition strut > 260 µm at 1 month and 3 months OCT after stent implantation.

Inclusion Criteria: Aged ≥ 18 years Signature of informed consent Patients with angina and a clinical indication for coronary revascularisation with a drug-eluting stent Presence of at least 2 lesions to be revascularised with similar angiographic characteristics Reference lesion diameter with at most a difference of 0.5 mm Maximum difference in lesion length of 10 mm Lesions able to be treated with only 1 stent Exclusion Criteria: Lesions due to restenosis Lesions in saphenous vein grafts STE-ACS ( ST elevation- Acute Coronary Syndrome) Cardiogenic shock Dual antiplatelet therapy contraindication for> 3 months Follow-up catheterisation contraindicated Chronic kidney failure with creatinine > 2 mg/dL Allergy to iodinated contrast agents Serious complication from vascular access in previous catheterisation Ineligible for evaluation via optical coherence tomography Lesion located <5 mm from aorto-ostial junction Severe proximal angulation >90º Bifurcation lesion requiring a strategy with two stents Angiographic characteristics that promote stent malposition Aneurysm or coronary artery ectasia Presence of a thrombus classed as TIMI (Thrombolysis In Myocardial Infarction )2 flow or higher Severe calcification, in particular in cases of calcium spike Severe lesion angulation Inability to do reliable follow-up, in the investigator's opinion

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