Intraoperative Opioids and Postoperative Recovery After Hepatobiliary or Foregut Surgery
Postoperative Pain
About this trial
This is an interventional treatment trial for Postoperative Pain focused on measuring Methadone, Hydromorphone, Hepatobiliary surgery, Postoperative pain
Eligibility Criteria
Inclusion Criteria:
- All patients presenting for elective hepatobiliary or foregut surgery will be eligible for enrollment
Exclusion Criteria:
Exclusion criteria include:
- Preoperative renal failure (defined as a serum creatinine > 2.0 mg/dL.)
- Morbid obesity
- American Society of Anesthesiologists Physical Status IV or V
- Age > 80 years
- Pulmonary disease necessitating home oxygen therapy
- Allergy to methadone or hydromorphone
- Preoperative recent history of opioid or alcohol abuse
Sites / Locations
- NorthShore University HealthSystem
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Methadone
Hydromorphone
Patients in the methadone group will be administered 0.3 mg/kg of methadone intraoperatively: two-thirds of the dose (6 cc or 0.2 mg/kg of methadone) on induction of anesthesia as a bolus. The remainder of the dose (3 cc or 0.1 mg/kg of methadone) will be administered at approximately 1.5-2 hours before the end of the procedure.
Patients in the hydromorphone group will receive 0.03 mg/kg of hydromorphone; two-thirds the dose (6 cc or 0.02 mg/kg) on induction of anesthesia, and the remainder of the hydromorphone (3 cc or 0.01 mg/kg) will be bolused 1.5-2 hours before surgery concludes.